Guardant Health

GH • NASDAQ

Guardant Health is a medical - diagnostics & research company in the healthcare sector on NASDAQ, led by AmirAli Talasaz, with a market cap of $13.3B. As of Q3 2025, 98% of shares are held by 383 institutional investors, with VANGUARD GROUP INC as the largest holder at 9.55%.

Co-Chief Executive OfficerAmirAli Talasaz

Market Cap$13.3B

Medical - Diagnostics & Research

Healthcare

Employees1.8K

Websiteguardanthealth.com

Country

United States of America

Overview

Overview of institutional ownership in GH as of Q3 2025 with a market cap of $7.8B

All Institutions

Institutions: 383
Value Held: $7.7B
Shares Held: 122.5M
Avg Position: $20.0M
Median Position: $1.0M

Hedge Funds

Hedge Funds: 56
Value Held: $1.3B
Shares Held: 21.5M
Avg Position: $24.0M
Median Position: $3.7M

Ownership Breakdown

Institutional (non-HF)

80.96%

$6.3B

Hedge Funds

17.23%

$1.3B

Retail & Other

1.81%

$140.9M

Based on market cap of $7.8B as of Q3 2025. Institutional (non-HF) excludes hedge funds to avoid double counting.

Biggest Investors

Institutions with the largest positions in GH as of Q3 2025

Institution	Key People	Position Value	Ownership	Owned Since	Total AUM (Long)
VANGUARD GROUP INC Institution	Salim Ramji CEO	$744.1M 0.01% of portfolio	9.55% 11.9M shares	Q4 2018 Held for 6y 11m	$6.69T
B BlackRock, Inc. Institution	-	$714.1M 0.01% of portfolio	9.17% 11.4M shares	Q4 2018 Held for 6y 11m	$5.67T
B BAILLIE GIFFORD & CO Institution	-	$320.4M 0.24% of portfolio	4.11% 5.1M shares	Q4 2023 Held for 1y 11m	$134.80B
Invesco Ltd. ETF Provider	Brian Christopher Hartigan CEO	$308.0M 0.05% of portfolio	3.95% 4.9M shares	Q1 2019 Held for 6y 8m	$633.08B
C Capital International Investors Institution	-	$293.0M 0.05% of portfolio	3.76% 4.7M shares	Q4 2020 Held for 4y 11m	$615.90B
PRICE T ROWE ASSOCIATES INC /MD/ Long Only Manager	Robert W Sharps President	$263.8M 0.03% of portfolio	3.39% 4.2M shares	Q4 2018 Held for 6y 11m	$912.31B
Deep Track Capital, LP Hedge Fund•Long/Short	David Eric Kroin CIO	$259.5M 7.38% of portfolio	3.33% 4.2M shares	Q2 2023 Held for 2y 5m	$3.5B
E EVENTIDE ASSET MANAGEMENT, LLC Long Only Manager	Robin Cheriakalath John CEO	$207.5M 3.41% of portfolio	2.66% 3.3M shares	Q3 2021 Held for 4y 2m	$6.1B
WELLINGTON MANAGEMENT CO LLP Long Only Manager	Jean Marie Hynes CEO	$203.0M 0.04% of portfolio	2.61% 3.2M shares	Q2 2023 Held for 2y 5m	$571.21B
GEODE CAPITAL MANAGEMENT LLC ETF Provider	David Kenneth Lane CEO	$183.5M 0.01% of portfolio	2.35% 2.9M shares	Q4 2018 Held for 6y 11m	$1.57T

Net Capital Flow

Institutional buying and selling activity for GH in Q3 2025

Traded: +$37.1M
Buyers: 197
Sellers: 169
Total Bought: +$1.2B
Total Sold: −$1.1B
Avg Position: $18.2M

Biggest Buyers

Institution	Net Bought	Current Position
PRICE T ROWE ASSOCIATES INC /MD/ Long Only Manager	+$153.5M +2.5M shares	$263.8M 4.2M shares
A Alyeska Investment Group, L.P. Hedge Fund•Multi-Strategy	+$114.4M +1.8M shares	$114.4M 1.8M shares
Invesco Ltd. ETF Provider	+$85.7M +1.4M shares	$308.0M 4.9M shares
WELLINGTON MANAGEMENT CO LLP Long Only Manager	+$82.9M +1.3M shares	$203.0M 3.2M shares
JENNISON ASSOCIATES LLC Long Only Manager	+$47.2M +755.8K shares	$91.9M 1.5M shares
LORD, ABBETT & CO. LLC Long Only Manager	+$39.7M +635.9K shares	$95.2M 1.5M shares
Allspring Global Investments Holdings, LLC Long Only Manager	+$39.5M +630.9K shares	$39.5M 630.9K shares
RTW INVESTMENTS, LLC Hedge Fund•Sector	+$39.0M +624.5K shares	$92.5M 1.5M shares
FRANKLIN RESOURCES INC Institution	+$37.9M +606.4K shares	$182.8M 2.9M shares
B BlackRock, Inc. Institution	+$28.1M +449.8K shares	$714.1M 11.4M shares

Biggest Sellers

Institution	Net Sold	Current Position
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	−$164.6M −2.6M shares	$19.0M 304.5K shares
ARK Investment Management LLC ETF Provider	−$126.7M −2.0M shares	$49.7M 795.2K shares
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	−$115.2M −1.8M shares	$54.9M 878.6K shares
Nikko Asset Management Americas, Inc. Long Only Manager	−$79.8M −1.3M shares	$47.1M 753.9K shares
S Sumitomo Mitsui Trust Holdings, Inc. Institution	−$79.8M −1.3M shares	$47.1M 754.2K shares
CADIAN CAPITAL MANAGEMENT, LLC Hedge Fund•Long/Short	−$64.9M −1.0M shares	$133.8M 2.1M shares
B BRAIDWELL LP Hedge Fund•Multi-Strategy	−$43.6M −837.8K shares	Sold Off 0 shares
UBS GLOBAL ASSET MANAGEMENT AMERICAS INC Long Only Manager	−$42.0M −672.1K shares	$141.3M 2.3M shares
R Railway Pension Investments Ltd Institution	−$32.3M −620.9K shares	Sold Off 0 shares
MPM Oncology Impact Management LP Institution	−$23.0M −442.7K shares	Sold Off 0 shares

Entry and Exit Activity

Institutions that initiated new positions or completely exited GH in Q3 2025

New Positions: 25
New Value: $29.7M
Exited Positions: 37
Exited Value: $162.9M

New Positions

Institution	Position Value
JUPITER ASSET MANAGEMENT LTD Long Only Manager	$13.0M 207.8K shares
Susquehanna Portfolio Strategies, LLC Private Equity	$6.8M 108.5K shares
Calamos Advisors LLC Long Only Manager	$2.8M 44.5K shares
C Capricorn Fund Managers Ltd Institution	$2.3M 36.2K shares
Inspire Advisors, LLC RIA/Wealth	$736.3K 11.8K shares
I INCEPTIONR LLC Hedge Fund•Quant	$670.2K 10.7K shares
Semanteon Capital Management, LP Hedge Fund•Long/Short	$568.4K 9.1K shares
NAVELLIER & ASSOCIATES INC RIA/Wealth	$484.5K 7.8K shares
Alta Wealth Advisors LLC RIA/Wealth	$405.9K 6.5K shares
B Birchview Capital, LP Hedge Fund•Value	$374.9K 6.0K shares

Exited Positions

Institution	Previous Position
B BRAIDWELL LP Hedge Fund•Multi-Strategy	$43.6M 837.8K shares
R Railway Pension Investments Ltd Institution	$32.3M 620.9K shares
MPM Oncology Impact Management LP Institution	$23.0M 442.7K shares
C Cubist Systematic Strategies, LLC Institution	$17.1M 329.3K shares
F First Turn Management, LLC Hedge Fund•Long/Short	$15.7M 302.3K shares
VOLORIDGE INVESTMENT MANAGEMENT, LLC Hedge Fund•Multi-Strategy	$9.0M 173.4K shares
R READYSTATE ASSET MANAGEMENT LP Hedge Fund•Multi-Strategy	$5.2M 100.1K shares
PRIMECAP MANAGEMENT CO/CA/ Long Only Manager	$3.4M 66.0K shares
Hawk Ridge Management LLC Hedge Fund•Long/Short	$3.3M 63.8K shares
Shaolin Capital Management LLC Hedge Fund•Multi-Strategy	$2.9M 55.0K shares

Options Activity

Institutions with the largest Call and Put options positions in GH as of Q3 2025

Call Positions: 16
Call Value: $134.3M
Put Positions: 17
Put Value: $163.7M

Call Positions

Institution	Position Value
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$50.8M 8.1K contracts
J JANE STREET GROUP, LLC Institution	$28.4M 4.6K contracts
Caption Management, LLC Hedge Fund•Long/Short	$16.1M 2.6K contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$11.9M 1.9K contracts
Walleye Trading LLC RIA/Wealth	$10.9M 1.7K contracts
LEUCADIA NATIONAL CORP Institution	$5.7M 905.0 contracts
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	$2.1M 341.0 contracts
T Twin Tree Management, LP Hedge Fund•Vol Arbitrage	$2.1M 332.0 contracts
L LMR Partners LLP Institution	$1.8M 281.0 contracts
S Squarepoint Ops LLC Hedge Fund•Quant	$1.3M 212.0 contracts

Put Positions

Institution	Position Value
P Parallax Volatility Advisers, LLC Hedge Fund•Vol Arbitrage	$87.5M 14.0K contracts
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$19.8M 3.2K contracts
Caption Management, LLC Hedge Fund•Long/Short	$17.7M 2.8K contracts
J JANE STREET GROUP, LLC Institution	$12.1M 1.9K contracts
LEUCADIA NATIONAL CORP Institution	$7.7M 1.2K contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$5.9M 948.0 contracts
Walleye Trading LLC RIA/Wealth	$4.3M 690.0 contracts
Walleye Trading Advisors, LLC Hedge Fund•Multi-Strategy	$2.3M 366.0 contracts
S Squarepoint Ops LLC Hedge Fund•Quant	$1.9M 308.0 contracts
BALYASNY ASSET MANAGEMENT LLC Hedge Fund•Multi-Strategy	$1.1M 181.0 contracts

Most Committed Institutions

Institutions with GH as the highest % of their portfolio as of Q3 2025

Institution	Key People	Portfolio Weight	Ownership	Owned Since	Total AUM (Long)
Blue Water Life Science Advisors, LLC RIA/Wealth	Nathaniel Thomas Cornell Managing Partner	23.12% $25.3M	0.33% 405.6K shares	Q4 2020 Held for 4y 11m	$109.6M
CADIAN CAPITAL MANAGEMENT, LLC Hedge Fund•Long/Short	Conor O'Brien CFO	7.95% $133.8M	1.72% 2.1M shares	Q4 2023 Held for 1y 11m	$1.7B
Deep Track Capital, LP Hedge Fund•Long/Short	David Eric Kroin CIO	7.38% $259.5M	3.33% 4.2M shares	Q2 2023 Held for 2y 5m	$3.5B
E Eagle Health Investments LP Hedge Fund•Long/Short	Gary Johnathan Stern Founder	4.66% $17.8M	0.23% 284.1K shares	Q2 2025 Held for 5 months	$380.9M
Exome Asset Management LLC Hedge Fund•Sector	Alex R Forschner President	4.14% $6.1M	0.08% 98.2K shares	Q1 2024 Held for 1y 8m	$148.0M
Sicart Associates LLC Family Office	Yibo (Nmn) Huang President	3.89% $14.4M	0.18% 230.1K shares	Q2 2021 Held for 4y 5m	$369.1M
Iron Triangle Partners LP Hedge Fund•Long/Short	Michael John O'Brien CFO	3.55% $25.0M	0.32% 400.0K shares	Q1 2025 Held for 8 months	$703.3M
E EVENTIDE ASSET MANAGEMENT, LLC Long Only Manager	Robin Cheriakalath John CEO	3.41% $207.5M	2.66% 3.3M shares	Q3 2021 Held for 4y 2m	$6.1B
EMERALD MUTUAL FUND ADVISERS TRUST Long Only Manager	Stacey Lynn Sears President	1.85% $34.7M	0.45% 556.0K shares	Q1 2025 Held for 8 months	$1.9B
Adalta Capital Management LLC RIA/Wealth	David Edward Rappa Member	1.80% $4.0M	0.05% 63.3K shares	Q2 2019 Held for 6y 5m	$220.3M

Hedge Fund Spotlight

Discover hedge funds investing in GH

First Light Asset Management, LLC

Hedge Fund • Sector

Portfolio ManagerMathew Paul Arens

Portfolio Value: $1.1B
Positions: 41
Last Reported: Q3 2025

Sector Allocation

Position in Guardant Health

Market Value: $17.5M
Shares Held: 280.0K
Portfolio Weight: 1.65%
Owned Since: 2022-Q4

Top Holding	Sector	Market Value	Weight
1 Axogen AXGN	Medical - Devices Healthcare	$103.6M	9.76%
2 PHLT Performant Healthcare PHLT	Unknown Unknown	$90.6M	8.54%
3 CNTA Centessa Pharmaceuticals CNTA	Unknown Unknown	$88.2M	8.31%

View full profile

Guardant Health

Overview

All Institutions

Hedge Funds

Ownership Breakdown

Biggest Investors

Net Capital Flow

Biggest Buyers

Biggest Sellers

Entry and Exit Activity

New Positions

Exited Positions

Options Activity

Call Positions

Put Positions

Most Committed Institutions

Hedge Fund Spotlight

Position in Guardant Health

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