Repligen

RGEN • NASDAQ

Repligen is a medical - instruments & supplies company in the healthcare sector on NASDAQ, led by Olivier Loeillot, with a market cap of $8.9B. As of Q3 2025, 106% of shares are held by 441 institutional investors, with BlackRock, Inc. as the largest holder at 10.91%.

Chief Executive OfficerOlivier Loeillot

Market Cap$8.9B

Medical - Instruments & Supplies

Healthcare

Employees1.8K

Websiterepligen.com

Country

United States of America

Overview

Overview of institutional ownership in RGEN as of Q3 2025 with a market cap of $7.5B

All Institutions

Institutions: 441
Value Held: $8.0B
Shares Held: 59.8M
Avg Position: $18.1M
Median Position: $869.5K

Hedge Funds

Hedge Funds: 54
Value Held: $1.3B
Shares Held: 10.0M
Avg Position: $24.7M
Median Position: $4.2M

Ownership Breakdown

Institutional (non-HF)

88.54%

$6.7B

Hedge Funds

17.76%

$1.3B

Retail & Other

Based on market cap of $7.5B as of Q3 2025. Institutional (non-HF) excludes hedge funds to avoid double counting.

Biggest Investors

Institutions with the largest positions in RGEN as of Q3 2025

Institution	Key People	Position Value	Ownership	Owned Since	Total AUM (Long)
B BlackRock, Inc. Institution	-	$820.7M 0.01% of portfolio	10.91% 6.1M shares	≤ Q2 2013 Held for 12y 5m+	$5.67T
VANGUARD GROUP INC Institution	Salim Ramji CEO	$674.3M 0.01% of portfolio	8.97% 5.0M shares	≤ Q2 2013 Held for 12y 5m+	$6.69T
PRICE T ROWE ASSOCIATES INC /MD/ Long Only Manager	Robert W Sharps President	$468.8M 0.05% of portfolio	6.23% 3.5M shares	Q2 2015 Held for 10y 5m	$912.31B
UNITED CAPITAL FINANCIAL ADVISERS, LLC RIA/Wealth	James Francis Rivers President	$368.4M 2.66% of portfolio	4.90% 2.8M shares	Q3 2025 Held for 2 months	$13.8B
FMR LLC Institution	-	$359.7M 0.02% of portfolio	4.78% 2.7M shares	≤ Q2 2013 Held for 12y 5m+	$1.92T
STATE STREET CORP Institution	Ronald P. O'Hanley CEO	$240.8M 0.01% of portfolio	3.20% 1.8M shares	≤ Q2 2013 Held for 12y 5m+	$2.88T
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	Kenneth Cordele Griffin CEO	$225.2M 0.18% of portfolio	2.99% 1.7M shares	≤ Q2 2013 Held for 12y 5m+	$122.08B
Point72 Asset Management, L.P. Hedge Fund•Multi-Strategy	Steven Alan Cohen CEO	$192.6M 0.45% of portfolio	2.56% 1.4M shares	Q3 2018 Held for 7y 2m	$43.2B
Holocene Advisors, LP Hedge Fund•Long/Short	John Brandon Haley CIO	$184.1M 0.42% of portfolio	2.45% 1.4M shares	Q4 2024 Held for 11 months	$43.5B
C Champlain Investment Partners, LLC Long Only Manager	Judith Wilkinson O'Connell CEO	$179.0M 1.35% of portfolio	2.38% 1.3M shares	Q3 2022 Held for 3y 2m	$13.3B

Net Capital Flow

Institutional buying and selling activity for RGEN in Q3 2025

Traded: +$341.5M
Buyers: 237
Sellers: 210
Total Bought: +$1.6B
Total Sold: −$1.2B
Avg Position: $15.7M

Biggest Buyers

Institution	Net Bought	Current Position
UNITED CAPITAL FINANCIAL ADVISERS, LLC RIA/Wealth	+$368.4M +2.8M shares	$368.4M 2.8M shares
FMR LLC Institution	+$144.1M +1.1M shares	$359.7M 2.7M shares
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	+$83.1M +621.7K shares	$225.2M 1.7M shares
BALYASNY ASSET MANAGEMENT LLC Hedge Fund•Multi-Strategy	+$81.7M +610.8K shares	$102.6M 767.2K shares
Holocene Advisors, LP Hedge Fund•Long/Short	+$58.9M +440.3K shares	$184.1M 1.4M shares
PointState Capital LP Hedge Fund•Multi-Strategy	+$54.7M +409.5K shares	$54.7M 409.5K shares
Vestal Point Capital, LP Hedge Fund•Long/Short	+$53.5M +400.0K shares	$53.5M 400.0K shares
Iron Triangle Partners LP Hedge Fund•Long/Short	+$36.1M +270.0K shares	$36.1M 270.0K shares
SCHRODER INVESTMENT MANAGEMENT GROUP RIA/Wealth	+$34.0M +254.2K shares	$61.6M 460.6K shares
D D. E. Shaw & Co., Inc. Institution	+$32.7M +244.3K shares	$33.4M 249.9K shares

Biggest Sellers

Institution	Net Sold	Current Position
PRICE T ROWE ASSOCIATES INC /MD/ Long Only Manager	−$413.9M −3.1M shares	$468.8M 3.5M shares
SANDS CAPITAL MANAGEMENT, LLC Long Only Manager	−$155.6M −1.3M shares	Sold Off 0 shares
Invesco Ltd. ETF Provider	−$67.6M −506.1K shares	$116.7M 873.0K shares
Point72 Asset Management, L.P. Hedge Fund•Multi-Strategy	−$63.2M −472.5K shares	$192.6M 1.4M shares
ExodusPoint Capital Management, LP Hedge Fund•Multi-Strategy	−$57.1M −427.2K shares	$8.6M 64.5K shares
N NEW YORK STATE COMMON RETIREMENT FUND Institution	−$47.9M −358.5K shares	$33.1M 247.5K shares
BROWN CAPITAL MANAGEMENT LLC Long Only Manager	−$45.0M −336.4K shares	$89.4M 668.9K shares
A Alyeska Investment Group, L.P. Hedge Fund•Multi-Strategy	−$38.8M −290.3K shares	$16.4M 123.0K shares
TWO SIGMA INVESTMENTS LLC Hedge Fund•Multi-Strategy	−$29.2M −218.3K shares	$12.7M 94.9K shares
RAYMOND JAMES FINANCIAL INC RIA/Wealth	−$27.5M −205.9K shares	$20.1M 150.1K shares

Entry and Exit Activity

Institutions that initiated new positions or completely exited RGEN in Q3 2025

New Positions: 32
New Value: $70.1M
Exited Positions: 65
Exited Value: $264.2M

New Positions

Institution	Position Value
Vestal Point Capital, LP Hedge Fund•Long/Short	$53.5M 400.0K shares
Delta Investment Management, LLC RIA/Wealth	$6.8M 50.7K shares
KELLY LAWRENCE W & ASSOCIATES INC/CA RIA/Wealth	$5.5M 41.1K shares
Lighthouse Investment Partners, LLC Fund of Funds	$1.7M 13.0K shares
M Mitsubishi UFJ Asset Management Ltd. Institution	$534.7K 4.0K shares
W Whalen Wealth Management Inc. RIA/Wealth	$455.9K 3.4K shares
WASHINGTON CAPITAL MANAGEMENT INC Real Assets	$374.3K 2.8K shares
ARMISTICE CAPITAL, LLC Hedge Fund•Long/Short	$316.4K 2.4K shares
SUMMIT WEALTH GROUP LLC / CO RIA/Wealth	$221.5K 1.4K shares
A Arrowpoint Investment Partners Pte. Ltd. Institution	$203.2K 1.5K shares

Exited Positions

Institution	Previous Position
SANDS CAPITAL MANAGEMENT, LLC Long Only Manager	$155.6M 1.3M shares
WELLINGTON MANAGEMENT CO LLP Long Only Manager	$17.8M 143.5K shares
Hawk Ridge Management LLC Hedge Fund•Long/Short	$14.4M 115.4K shares
T TWINBEECH CAPITAL LP Hedge Fund•Quant	$11.7M 94.4K shares
ZEVENBERGEN CAPITAL INVESTMENTS LLC Long Only Manager	$10.7M 86.0K shares
London & Capital Asset Management Ltd Digital Asset Manager	$6.8M 55.0K shares
A AWM Investment Company, Inc. Hedge Fund•Event Driven	$5.6M 45.0K shares
Engineers Gate Manager LP Hedge Fund•Quant	$5.2M 41.5K shares
CAPITAL FUND MANAGEMENT S.A. Hedge Fund•Quant Macro	$4.3M 34.9K shares
R Roubaix Capital, LLC Hedge Fund•Long/Short	$3.3M 26.5K shares

Options Activity

Institutions with the largest Call and Put options positions in RGEN as of Q3 2025

Call Positions: 13
Call Value: $41.6M
Put Positions: 12
Put Value: $89.1M

Call Positions

Institution	Position Value
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$14.6M 1.1K contracts
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	$10.0M 751.0 contracts
J JANE STREET GROUP, LLC Institution	$4.8M 358.0 contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$4.7M 351.0 contracts
T Twin Tree Management, LP Hedge Fund•Vol Arbitrage	$2.4M 178.0 contracts
D D. E. Shaw & Co., Inc. Institution	$1.8M 138.0 contracts
W WOLVERINE TRADING, LLC Institution	$1.8M 147.0 contracts
M MOORE CAPITAL MANAGEMENT, LP Hedge Fund•Global Macro	$1.1M 80.0 contracts
TUDOR INVESTMENT CORP ET AL Hedge Fund•Multi-Strategy	$267.3K 20.0 contracts
Walleye Trading LLC RIA/Wealth	$66.8K 5.0 contracts

Put Positions

Institution	Position Value
J JANE STREET GROUP, LLC Institution	$51.6M 3.9K contracts
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$16.2M 1.2K contracts
Caption Management, LLC Hedge Fund•Long/Short	$6.7M 500.0 contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$5.3M 396.0 contracts
D D. E. Shaw & Co., Inc. Institution	$2.8M 211.0 contracts
BARCLAYS PLC Institution	$2.7M 200.0 contracts
P Parallax Volatility Advisers, LLC Hedge Fund•Vol Arbitrage	$2.0M 150.0 contracts
Verition Fund Management LLC Hedge Fund•Multi-Strategy	$1.0M 75.0 contracts
W WOLVERINE TRADING, LLC Institution	$546.0K 44.0 contracts
Walleye Trading LLC RIA/Wealth	$227.2K 17.0 contracts

Most Committed Institutions

Institutions with RGEN as the highest % of their portfolio as of Q3 2025

Institution	Key People	Portfolio Weight	Ownership	Owned Since	Total AUM (Long)
Iron Triangle Partners LP Hedge Fund•Long/Short	Michael John O'Brien CFO	5.13% $36.1M	0.48% 270.0K shares	Q3 2025 Held for 2 months	$703.3M
BROWN CAPITAL MANAGEMENT LLC Long Only Manager	Keith Allison Lee CEO	3.68% $89.4M	1.19% 668.9K shares	Q1 2021 Held for 4y 8m	$2.4B
1 12 West Capital Management LP Hedge Fund•Long/Short	Joel Nmn Ramin Managing Partner	3.34% $32.2M	0.43% 241.2K shares	Q2 2019 Held for 6y 5m	$964.1M
Vestal Point Capital, LP Hedge Fund•Long/Short	Ryan Christopher Wilder CIO	2.71% $53.5M	0.71% 400.0K shares	Q3 2025 Held for 2 months	$2.0B
UNITED CAPITAL FINANCIAL ADVISERS, LLC RIA/Wealth	James Francis Rivers President	2.66% $368.4M	4.90% 2.8M shares	Q3 2025 Held for 2 months	$13.8B
Conestoga Capital Advisors, LLC Long Only Manager	Joseph Francis Monahan Partner	2.05% $127.9M	1.70% 956.9K shares	Q2 2014 Held for 11y 5m	$6.2B
Sivik Global Healthcare LLC Hedge Fund•Long/Short	Krishen Kumar Sud Managing Partner	1.99% $3.7M	0.05% 27.5K shares	Q2 2024 Held for 1y 5m	$184.7M
AMERICAN CAPITAL MANAGEMENT INC Long Only Manager	David Mark La Valle CEO	1.79% $45.0M	0.60% 336.9K shares	Q3 2018 Held for 7y 2m	$2.5B
L LRT Capital Management, LLC Institution	-	1.74% $2.6M	0.03% 19.6K shares	Q4 2021 Held for 3y 11m	$150.9M
B Blue Whale Capital LLP Institution	-	1.72% $32.5M	0.43% 243.1K shares	Q2 2025 Held for 5 months	$1.9B

Hedge Fund Spotlight

Discover hedge funds investing in RGEN

DEERFIELD MANAGEMENT CO /NY

Hedge Fund • Long/Short

Portfolio ManagerJames Edward Flynn

Portfolio Value: $6.0B
Positions: 142
Last Reported: Q3 2025

Sector Allocation

Position in Repligen

Market Value: $1.7M
Shares Held: 12.9K
Portfolio Weight: 0.03%
Owned Since: 2025-Q2

Top Holding	Sector	Market Value	Weight
1 Nuvalent, Inc. NUVL	Biotechnology Healthcare	$1.6B	25.79%
2 Centene CNC	Medical - Healthcare Plans Healthcare	$322.8M	5.35%
3 Merus N.V. MRUS	Biotechnology Healthcare	$286.9M	4.75%