Repare Therapeutics

RPTX • NASDAQ

Repare Therapeutics is a biotechnology company in the healthcare sector on NASDAQ, led by Lloyd M. Segal, with a market cap of $92.0M. As of Q3 2025, 63% of shares are held by 44 institutional investors, with BVF INC/IL as the largest holder at 24.05%.

CEOLloyd M. Segal

Market Cap$92.0M

Biotechnology

Healthcare

Employees179.0

Websitereparerx.com

Country

United States of America

Overview

Overview of institutional ownership in RPTX as of Q3 2025 with a market cap of $75.6M

All Institutions

Institutions: 44
Value Held: $48.0M
Shares Held: 27.3M
Avg Position: $1.1M
Median Position: $62.3K

Hedge Funds

Hedge Funds: 13
Value Held: $13.1M
Shares Held: 7.5M
Avg Position: $1.0M
Median Position: $209.8K

Ownership Breakdown

Institutional (non-HF)

46.1%

$34.9M

Hedge Funds

17.38%

$13.1M

Retail & Other

36.52%

$27.6M

Based on market cap of $75.6M as of Q3 2025. Institutional (non-HF) excludes hedge funds to avoid double counting.

Biggest Investors

Institutions with the largest positions in RPTX as of Q3 2025

Institution	Key People	Position Value	Ownership	Owned Since	Total AUM (Long)
B BVF INC/IL Institution	-	$18.2M 0.74% of portfolio	24.05% 10.3M shares	Q2 2020 Held for 5y 5m	$2.5B
B Blue Owl Capital Holdings LP Institution	-	$6.1M 1.90% of portfolio	8.02% 3.4M shares	Q4 2023 Held for 1y 11m	$318.8M
ORBIMED ADVISORS LLC Hedge Fund•Sector	Sam Block Iii CFO	$5.8M 0.14% of portfolio	7.73% 3.3M shares	Q2 2020 Held for 5y 5m	$4.1B
V Versant Venture Management, LLC Institution	-	$4.7M 2.19% of portfolio	6.16% 2.6M shares	Q2 2023 Held for 2y 5m	$212.5M
R Redmile Group, LLC Hedge Fund•Sector	Amrit Nmn Nagpal Managing Partner	$2.8M 0.27% of portfolio	3.69% 1.6M shares	Q2 2020 Held for 5y 5m	$1.0B
MPM ASSET MANAGEMENT LLC Venture Capital	Ansbert Karl Gadicke Managing Partner	$2.0M 4.43% of portfolio	2.61% 1.1M shares	Q2 2020 Held for 5y 5m	$44.5M
MPM Oncology Impact Management LP Institution	Christian Albrecht Wulf Von Schimmelmann Managing Partner	$1.4M 0.24% of portfolio	1.91% 819.9K shares	Q2 2020 Held for 5y 5m	$610.9M
RENAISSANCE TECHNOLOGIES LLC Hedge Fund•Quant	Peter Fitzhugh Brown CEO	$1.3M 0.00% of portfolio	1.69% 724.2K shares	Q2 2021 Held for 4y 5m	$75.8B
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	Kenneth Cordele Griffin CEO	$1.2M 0.00% of portfolio	1.63% 699.3K shares	Q2 2020 Held for 5y 5m	$122.08B
R Rangeley Capital, LLC Hedge Fund•Event Driven	Christopher Clay Demuth Jr. Managing Partner	$1.1M 1.08% of portfolio	1.50% 645.9K shares	Q2 2025 Held for 5 months	$105.5M

Net Capital Flow

Institutional buying and selling activity for RPTX in Q3 2025

Traded: −$586.4K
Buyers: 10
Sellers: 15
Total Bought: +$1.1M
Total Sold: −$1.7M
Avg Position: $888.9K

Biggest Buyers

Institution	Net Bought	Current Position
R Rangeley Capital, LLC Hedge Fund•Event Driven	+$511.4K +290.6K shares	$1.1M 645.9K shares
RENAISSANCE TECHNOLOGIES LLC Hedge Fund•Quant	+$354.3K +201.3K shares	$1.3M 724.2K shares
S Squarepoint Ops LLC Hedge Fund•Quant	+$114.8K +65.2K shares	$114.8K 65.2K shares
Lantern Wealth Advisors, LLC RIA/Wealth	+$35.2K +20.0K shares	$35.2K 20.0K shares
GSA CAPITAL PARTNERS LLP Hedge Fund•Quant	+$24.4K +13.9K shares	$24.4K 13.9K shares
SRS Capital Advisors, Inc. RIA/Wealth	+$13.2K +7.5K shares	$22.0K 12.5K shares
MORGAN STANLEY RIA/Wealth	+$11.0K +6.2K shares	$11.9K 6.7K shares
X XTX Topco Ltd Institution	+$7.7K +4.4K shares	$83.7K 47.5K shares
UBS Group AG Institution	+$6.3K +3.6K shares	$6.3K 3.6K shares
BANK OF AMERICA CORP /DE/ Institution	+$4.1K +2.3K shares	$22.6K 12.9K shares

Biggest Sellers

Institution	Net Sold	Current Position
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	−$566.9K −407.9K shares	Sold Off 0 shares
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	−$419.2K −238.2K shares	$1.2M 699.3K shares
ACADIAN ASSET MANAGEMENT LLC Long Only Manager	−$198.7K −112.9K shares	$1.0M 568.3K shares
Nikko Asset Management Americas, Inc. Long Only Manager	−$161.6K −116.2K shares	Sold Off 0 shares
S Sumitomo Mitsui Trust Holdings, Inc. Institution	−$161.6K −116.2K shares	Sold Off 0 shares
NORTHERN TRUST CORP Institution	−$41.9K −23.8K shares	$461.5K 262.2K shares
TWO SIGMA INVESTMENTS LLC Hedge Fund•Multi-Strategy	−$37.5K −21.3K shares	$19.3K 11.0K shares
STATE STREET CORP Institution	−$26.5K −19.1K shares	Sold Off 0 shares
GOLDMAN SACHS GROUP INC Institution	−$24.4K −17.5K shares	Sold Off 0 shares
S SIMPLEX TRADING, LLC Institution	−$11.2K −8.1K shares	Sold Off 0 shares

Entry and Exit Activity

Institutions that initiated new positions or completely exited RPTX in Q3 2025

New Positions: 1
New Value: $35.2K
Exited Positions: 9
Exited Value: $965.2K

New Positions

Institution	Position Value
Lantern Wealth Advisors, LLC RIA/Wealth	$35.2K 20.0K shares

Exited Positions

Institution	Previous Position
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	$566.9K 407.9K shares
S Sumitomo Mitsui Trust Holdings, Inc. Institution	$161.6K 116.2K shares
Nikko Asset Management Americas, Inc. Long Only Manager	$161.6K 116.2K shares
STATE STREET CORP Institution	$26.5K 19.1K shares
GOLDMAN SACHS GROUP INC Institution	$24.4K 17.5K shares
S SIMPLEX TRADING, LLC Institution	$11.2K 8.1K shares
G GROUP ONE TRADING, L.P. Institution	$8.0K 5.7K shares
T Tower Research Capital LLC Institution	$4.7K 3.4K shares
RAYMOND JAMES FINANCIAL INC RIA/Wealth	$320.0 230.0 shares

Options Activity

Institutions with the largest Call and Put options positions in RPTX as of Q3 2025

Call Positions: 2
Call Value: $190.3K
Put Positions: 0
Put Value: -

Call Positions

Institution	Position Value
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$190.3K 1.1K contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	- - contracts

Put Positions

Institution	Position Value
No put positions found

Most Committed Institutions

Institutions with RPTX as the highest % of their portfolio as of Q3 2025

Institution	Key People	Portfolio Weight	Ownership	Owned Since	Total AUM (Long)
MPM ASSET MANAGEMENT LLC Venture Capital	Ansbert Karl Gadicke Managing Partner	4.43% $2.0M	2.61% 1.1M shares	Q2 2020 Held for 5y 5m	$44.5M
V Versant Venture Management, LLC Institution	-	2.19% $4.7M	6.16% 2.6M shares	Q2 2023 Held for 2y 5m	$212.5M
B Blue Owl Capital Holdings LP Institution	-	1.90% $6.1M	8.02% 3.4M shares	Q4 2023 Held for 1y 11m	$318.8M
R Rangeley Capital, LLC Hedge Fund•Event Driven	Christopher Clay Demuth Jr. Managing Partner	1.08% $1.1M	1.50% 645.9K shares	Q2 2025 Held for 5 months	$105.5M
B BVF INC/IL Institution	-	0.74% $18.2M	24.05% 10.3M shares	Q2 2020 Held for 5y 5m	$2.5B
R Redmile Group, LLC Hedge Fund•Sector	Amrit Nmn Nagpal Managing Partner	0.27% $2.8M	3.69% 1.6M shares	Q2 2020 Held for 5y 5m	$1.0B
MPM Oncology Impact Management LP Institution	Christian Albrecht Wulf Von Schimmelmann Managing Partner	0.24% $1.4M	1.91% 819.9K shares	Q2 2020 Held for 5y 5m	$610.9M
ORBIMED ADVISORS LLC Hedge Fund•Sector	Sam Block Iii CFO	0.14% $5.8M	7.73% 3.3M shares	Q2 2020 Held for 5y 5m	$4.1B
Militia Capital Partners, LP Hedge Fund•Long/Short	-	0.11% $209.8K	0.28% 119.2K shares	Q2 2025 Held for 5 months	$195.8M
Affinity Asset Advisors, LLC Hedge Fund•Long/Short	Jonathan Bo-Shing Chu Founder	0.04% $352.0K	0.47% 200.0K shares	Q3 2024 Held for 1y 2m	$983.0M

Hedge Fund Spotlight

Discover hedge funds investing in RPTX

Rangeley Capital, LLC

Hedge Fund • Event Driven

Portfolio ManagerChristopher Clay Demuth Jr.

Portfolio Value: $105.5M
Positions: 115
Last Reported: Q3 2025

Sector Allocation

Position in Repare Therapeutics

Market Value: $1.1M
Shares Held: 645.9K
Portfolio Weight: 1.08%
Owned Since: 2025-Q2

Top Holding	Sector	Market Value	Weight
1 Delek US Holdings DK	Oil & Gas Refining & Marketing Energy	$6.6M	6.30%
2 Calumet, Inc. CLMT	Oil & Gas Exploration & Production Energy	$6.0M	5.72%
3 Arvinas ARVN	Biotechnology Healthcare	$5.9M	5.61%