Syndax Pharmaceuticals

SNDX • NASDAQ

Syndax Pharmaceuticals is a biotechnology company in the healthcare sector on NASDAQ, led by Michael A. Metzger, with a market cap of $1.8B. As of Q3 2025, 118% of shares are held by 225 institutional investors, with BlackRock, Inc. as the largest holder at 10.01%.

Chief Executive OfficerMichael A. Metzger

Market Cap$1.8B

Biotechnology

Healthcare

Employees184.0

Websitesyndax.com

Country

United States of America

Overview

Overview of institutional ownership in SNDX as of Q3 2025 with a market cap of $1.3B

All Institutions

Institutions: 225
Value Held: $1.6B
Shares Held: 101.3M
Avg Position: $6.9M
Median Position: $742.3K

Hedge Funds

Hedge Funds: 48
Value Held: $553.1M
Shares Held: 36.0M
Avg Position: $11.5M
Median Position: $4.3M

Ownership Breakdown

Institutional (non-HF)

75.77%

$1.0B

Hedge Funds

41.74%

$553.1M

Retail & Other

Based on market cap of $1.3B as of Q3 2025. Institutional (non-HF) excludes hedge funds to avoid double counting.

Biggest Investors

Institutions with the largest positions in SNDX as of Q3 2025

Institution	Key People	Position Value	Ownership	Owned Since	Total AUM (Long)
B BlackRock, Inc. Institution	-	$132.7M 0.00% of portfolio	10.01% 8.6M shares	Q1 2016 Held for 9y 8m	$5.67T
K Kynam Capital Management, LP Hedge Fund•Long/Short	Jared Joseph Keller COO	$131.1M 9.76% of portfolio	9.89% 8.5M shares	Q4 2021 Held for 3y 11m	$1.3B
GOLDMAN SACHS GROUP INC Institution	David M. Solomon CEO	$84.4M 0.01% of portfolio	6.37% 5.5M shares	Q4 2017 Held for 7y 11m	$691.34B
VANGUARD GROUP INC Institution	Salim Ramji CEO	$79.1M 0.00% of portfolio	5.97% 5.1M shares	Q2 2016 Held for 9y 5m	$6.69T
Point72 Asset Management, L.P. Hedge Fund•Multi-Strategy	Steven Alan Cohen CEO	$65.5M 0.15% of portfolio	4.94% 4.3M shares	Q4 2022 Held for 2y 11m	$43.2B
STATE STREET CORP Institution	Ronald P. O'Hanley CEO	$59.3M 0.00% of portfolio	4.47% 3.9M shares	Q2 2016 Held for 9y 5m	$2.88T
BANK OF AMERICA CORP /DE/ Institution	Brian T. Moynihan CEO	$56.9M 0.00% of portfolio	4.29% 3.7M shares	Q2 2016 Held for 9y 5m	$1.33T
Eversept Partners, LLC Hedge Fund•Long/Short	Rishi Rasesh Shah President	$53.3M 4.09% of portfolio	4.03% 3.5M shares	Q2 2022 Held for 3y 5m	$1.3B
A ADAGE CAPITAL PARTNERS GP LLC Institution	-	$51.0M 0.08% of portfolio	3.84% 3.3M shares	Q1 2019 Held for 6y 8m	$63.0B
K KINGDON CAPITAL MANAGEMENT, L.L.C. Hedge Fund•Long/Short	Mark Elliot Kingdon CEO	$38.5M 6.03% of portfolio	2.90% 2.5M shares	Q4 2023 Held for 1y 11m	$638.2M

Net Capital Flow

Institutional buying and selling activity for SNDX in Q3 2025

Traded: +$24.9M
Buyers: 123
Sellers: 94
Total Bought: +$245.7M
Total Sold: −$220.8M
Avg Position: $6.2M

Biggest Buyers

Institution	Net Bought	Current Position
Point72 Asset Management, L.P. Hedge Fund•Multi-Strategy	+$32.7M +2.1M shares	$65.5M 4.3M shares
A ADAGE CAPITAL PARTNERS GP LLC Institution	+$28.9M +1.9M shares	$51.0M 3.3M shares
MPM Oncology Impact Management LP Institution	+$21.2M +1.4M shares	$21.2M 1.4M shares
N Nuveen, LLC Institution	+$18.6M +1.2M shares	$22.7M 1.5M shares
Soleus Capital Management, L.P. Hedge Fund•Long/Short	+$14.2M +920.0K shares	$31.0M 2.0M shares
Bank of New York Mellon Corp Institution	+$12.5M +815.2K shares	$16.2M 1.1M shares
APIS CAPITAL ADVISORS, LLC Hedge Fund•Long/Short	+$9.8M +638.0K shares	$9.8M 638.0K shares
J JANE STREET GROUP, LLC Institution	+$8.8M +570.8K shares	$11.4M 738.3K shares
D D. E. Shaw & Co., Inc. Institution	+$6.7M +433.0K shares	$16.6M 1.1M shares
STATE STREET CORP Institution	+$6.3M +410.8K shares	$59.3M 3.9M shares

Biggest Sellers

Institution	Net Sold	Current Position
B BlackRock, Inc. Institution	−$28.2M −1.8M shares	$132.7M 8.6M shares
S SPHERA FUNDS MANAGEMENT LTD. Institution	−$18.2M −1.2M shares	$6.0M 387.7K shares
StemPoint Capital LP Hedge Fund•Long/Short	−$15.5M −1.0M shares	$21.0M 1.4M shares
S Sofinnova Ventures Inc Venture Capital	−$14.3M −1.5M shares	Sold Off 0 shares
Eversept Partners, LLC Hedge Fund•Long/Short	−$9.2M −598.0K shares	$53.3M 3.5M shares
GRANAHAN INVESTMENT MANAGEMENT INC/MA Long Only Manager	−$9.2M −595.1K shares	$6.1M 396.3K shares
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	−$8.5M −552.2K shares	$16.1M 1.0M shares
Catalio Capital Management, LP Venture Capital	−$7.5M −489.8K shares	$24.8M 1.6M shares
N Nantahala Capital Management, LLC Hedge Fund•Multi-Strategy	−$7.1M −754.5K shares	Sold Off 0 shares
E EVENTIDE ASSET MANAGEMENT, LLC Long Only Manager	−$6.5M −425.6K shares	$15.2M 988.5K shares

Entry and Exit Activity

Institutions that initiated new positions or completely exited SNDX in Q3 2025

New Positions: 16
New Value: $38.8M
Exited Positions: 26
Exited Value: $44.4M

New Positions

Institution	Position Value
MPM Oncology Impact Management LP Institution	$21.2M 1.4M shares
APIS CAPITAL ADVISORS, LLC Hedge Fund•Long/Short	$9.8M 638.0K shares
S SECTOR GAMMA AS Institution	$3.2M 210.8K shares
V Velan Capital Investment Management LP Institution	$2.0M 130.0K shares
Q Quadrature Capital Ltd Institution	$497.7K 32.4K shares
Cinctive Capital Management LP Hedge Fund•Multi-Strategy	$468.3K 30.4K shares
Post Resch Tallon Group Inc. RIA/Wealth	$396.9K 25.8K shares
Mariner Wealth Advisors, LLC RIA/Wealth	$360.6K 23.4K shares
W Winton Capital Group Ltd Institution	$346.5K 22.5K shares
C Concentric Capital Strategies, LP Hedge Fund•Long/Short	$337.6K 21.9K shares

Exited Positions

Institution	Previous Position
S Sofinnova Ventures Inc Venture Capital	$14.3M 1.5M shares
N Nantahala Capital Management, LLC Hedge Fund•Multi-Strategy	$7.1M 754.5K shares
Casdin Capital, LLC Hedge Fund•Sector	$6.1M 650.0K shares
Caption Management, LLC Hedge Fund•Long/Short	$4.7M 504.5K shares
S Saturn V Capital Management LLC Hedge Fund•Sector	$4.7M 500.6K shares
H HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND Institution	$1.5M 155.0K shares
A Avidity Partners Management LP Hedge Fund•Long/Short	$1.4M 150.0K shares
BALYASNY ASSET MANAGEMENT LLC Hedge Fund•Multi-Strategy	$1.2M 126.1K shares
Polar Securities Inc. Hedge Fund•Multi-Strategy	$909.5K 97.1K shares
UBS OCONNOR LLC Long Only Manager	$847.0K 90.4K shares

Options Activity

Institutions with the largest Call and Put options positions in SNDX as of Q3 2025

Call Positions: 13
Call Value: $21.7M
Put Positions: 11
Put Value: $11.3M

Call Positions

Institution	Position Value
Caption Management, LLC Hedge Fund•Long/Short	$9.5M 6.2K contracts
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$6.4M 4.1K contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$1.7M 1.1K contracts
StemPoint Capital LP Hedge Fund•Long/Short	$1.5M 1.0K contracts
UBS Group AG Institution	$1.1M 723.0 contracts
C CANTOR FITZGERALD, L. P. Institution	$769.5K 500.0 contracts
W WOLVERINE TRADING, LLC Institution	$308.1K 198.0 contracts
Walleye Trading Advisors, LLC Hedge Fund•Multi-Strategy	$289.2K 188.0 contracts
Walleye Trading LLC RIA/Wealth	$180.0K 117.0 contracts
J JANE STREET GROUP, LLC Institution	- - contracts

Put Positions

Institution	Position Value
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$4.3M 2.8K contracts
Caption Management, LLC Hedge Fund•Long/Short	$2.3M 1.5K contracts
BALYASNY ASSET MANAGEMENT LLC Hedge Fund•Multi-Strategy	$1.5M 1.0K contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$1.1M 691.0 contracts
LEUCADIA NATIONAL CORP Institution	$770.8K 501.0 contracts
J JANE STREET GROUP, LLC Institution	$610.8K 397.0 contracts
Walleye Trading Advisors, LLC Hedge Fund•Multi-Strategy	$341.5K 222.0 contracts
W WOLVERINE TRADING, LLC Institution	$233.4K 150.0 contracts
Walleye Trading LLC RIA/Wealth	$176.9K 115.0 contracts
N NOMURA HOLDINGS INC Institution	- - contracts

Most Committed Institutions

Institutions with SNDX as the highest % of their portfolio as of Q3 2025

Institution	Key People	Portfolio Weight	Ownership	Owned Since	Total AUM (Long)
K Kynam Capital Management, LP Hedge Fund•Long/Short	Jared Joseph Keller COO	9.76% $131.1M	9.89% 8.5M shares	Q4 2021 Held for 3y 11m	$1.3B
K KINGDON CAPITAL MANAGEMENT, L.L.C. Hedge Fund•Long/Short	Mark Elliot Kingdon CEO	6.03% $38.5M	2.90% 2.5M shares	Q4 2023 Held for 1y 11m	$638.2M
L Lion Point Capital, LP Hedge Fund•Event Driven	Carl Didric Marcus Cederholm CIO	4.81% $846.2K	0.06% 55.0K shares	Q2 2023 Held for 2y 5m	$17.6M
Catalio Capital Management, LP Venture Capital	Olga Eduardovna Maltseva COO	4.59% $24.8M	1.87% 1.6M shares	Q1 2025 Held for 8 months	$540.9M
A Aisling Capital Management LP Private Equity	Steven Arnote Elms President	4.44% $20.3M	1.53% 1.3M shares	Q1 2020 Held for 5y 8m	$456.4M
StemPoint Capital LP Hedge Fund•Long/Short	Sean Chua Tan President	4.24% $21.0M	1.59% 1.4M shares	Q4 2023 Held for 1y 11m	$495.9M
Prosight Management, LP Hedge Fund•Long/Short	William Lawrence Hawkins Managing Partner	4.10% $15.4M	1.16% 1.0M shares	Q2 2024 Held for 1y 5m	$376.7M
Eversept Partners, LLC Hedge Fund•Long/Short	Rishi Rasesh Shah President	4.09% $53.3M	4.03% 3.5M shares	Q2 2022 Held for 3y 5m	$1.3B
MPM Oncology Impact Management LP Institution	Christian Albrecht Wulf Von Schimmelmann Managing Partner	3.46% $21.2M	1.60% 1.4M shares	Q3 2025 Held for 2 months	$610.9M
K Knott David M Jr Institution	-	2.76% $6.6M	0.50% 428.0K shares	Q1 2024 Held for 1y 8m	$238.7M