SECTORAL ASSET MANAGEMENT INC

Venture Capital

SECTORAL ASSET MANAGEMENT INC is a Venture Capital led by Jerome Georges Pfund, reporting $392.4M in AUM as of Q3 2025 with 74% Healthcare concentration.

CEOJerome Georges Pfund

Portfolio Value: $159.6M
Positions: 81
Top Holding: CTNM at 5.9%
Last Reported: Q3 2025

Address1010 Sherbrooke Street, West, Suite 1610, Montreal, Quebec, H3A 2R7, Canada

Top Holdings

Largest long holdings in SECTORAL ASSET MANAGEMENT INC's portfolio (35.6% of total portfolio)

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Holding	Sector	Position	Weight	Traded	Ownership	Owned Since
1 Contineum Therapeutics, Inc. CTNM	Biotechnology Healthcare	$9.4M	5.90%	—	2.86% 800.8K shares	Q2 2024 Held for 1y 5m
2 Eli Lilly LLY	Drug Manufacturers - General Healthcare	$7.2M	4.48%	+$305.2K Bought	0.00% 9.4K shares	Q4 2017 Held for 7y 11m
3 GPCR Structure Therapeutics GPCR	Unknown Unknown	$6.2M	3.89%	+$4.8M Bought	— 221.9K shares	Q4 2023 Held for 1y 11m
4 AnaptysBio, Inc. ANAB	Biotechnology Healthcare	$6.0M	3.73%	+$3.4M Bought	0.70% 194.5K shares	Q2 2025 Held for 5 months
5 Siemens AG SI	Unknown Unknown	$5.4M	3.38%	+$5.4M New	2.11% 430.3K shares	Q3 2025 Held for 2 months
6 Arcus Biosciences RCUS	Biotechnology Healthcare	$5.0M	3.14%	+$1.5M Bought	0.35% 368.1K shares	Q1 2020 Held for 5y 8m
7 Immatics N.V. IMTX	Biotechnology Healthcare	$4.8M	2.99%	+$1.9M Bought	0.46% 560.5K shares	Q2 2025 Held for 5 months
8 UnitedHealth Group UNH	Medical - Healthcare Plans Healthcare	$4.7M	2.93%	-$1.1M Sold	0.00% 13.5K shares	Q4 2019 Held for 5y 11m
9 Bicara Therapeutics BCAX	Unknown Unknown	$4.2M	2.64%	+$1.0M Bought	0.49% 266.5K shares	Q2 2025 Held for 5 months
10 Oric Pharmaceuticals, Inc. ORIC	Biotechnology Healthcare	$3.9M	2.47%	+$1.2M Bought	0.34% 328.7K shares	Q1 2025 Held for 8 months

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Changes

Portfolio activity, position movements, and quarter-over-quarter changes in SECTORAL ASSET MANAGEMENT INC's latest filing

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Market Value

$159.6M

Prior: $149.6M

Q/Q Change

+6.66%

+$10.0M

Net Flows % of MV

-23.23%

Turnover Ratio

27.11%

New Purchases

1 stocks

$5.4M

Added To

29 stocks

+$22.7M

Sold Out Of

16 stocks

$37.4M

Reduced Holdings

27 stocks

-$27.8M

Increased Positions

Position	Shares Δ	Change
1 Siemens AG SI	New	0 → 430.3K +$5.4M
2 GPCR Structure Therapeutics GPCR	+331.92%	51.4K → 221.9K +$4.8M
3 AnaptysBio, Inc. ANAB	+131.81%	83.9K → 194.5K +$3.4M
4 Tectonic Therapeutics TECX	+94.78%	99.0K → 192.8K +$1.5M
5 Instil Bio TIL	+87.17%	86.2K → 161.4K +$1.3M

Decreased Positions

Position	Shares Δ	Change
1 LENZ Therapeutics, Inc. LENZ	Sold	977.2K → 0 −$28.6M
2 Replimune Group REPL	Sold	231.7K → 0 −$2.2M
3 Tourmaline Bio TRML	Sold	116.5K → 0 −$1.9M
4 Globus Medical GMED	Sold	13.5K → 0 −$796.8K
5 LEGN Legend Biotech LEGN	Sold	19.6K → 0 −$696.6K