Structure Therapeutics

GPCR • NASDAQ

Structure Therapeutics is a pharmaceutical preparations company on NASDAQ. As of Q3 2025, 127 institutional investors hold shares in this company, with total holdings valued at $1.4B. WELLINGTON MANAGEMENT CO LLP is the largest holder with a position valued at $159.3M.

PHARMACEUTICAL PREPARATIONS

Employees111.0

Websitestructuretx.com

Country

United States of America

Overview

Overview of institutional ownership in GPCR as of Q3 2025

All Institutions

Institutions: 127
Value Held: $1.4B
Shares Held: 51.2M
Avg Position: $11.3M
Median Position: $1.5M

Hedge Funds

Hedge Funds: 33
Value Held: $460.1M
Shares Held: 16.4M
Avg Position: $13.9M
Median Position: $6.6M

Biggest Investors

Institutions with the largest positions in GPCR as of Q3 2025

Institution	Key People	Position Value	Ownership	Owned Since	Total AUM (Long)
WELLINGTON MANAGEMENT CO LLP Long Only Manager	Jean Marie Hynes CEO	$159.3M 0.03% of portfolio	0.00% 5.7M shares	Q1 2023 Held for 2y 8m	$571.21B
FMR LLC Institution	-	$147.0M 0.01% of portfolio	0.00% 5.3M shares	Q1 2023 Held for 2y 8m	$1.92T
venBio Select Advisor LLC RIA/Wealth	Behzad Aghazadeh Managing Partner	$144.4M 1.87% of portfolio	0.00% 5.2M shares	Q3 2025 Held for 2 months	$7.7B
HENDERSON GROUP PLC Institution	Ali Dibadj CEO	$124.6M 0.06% of portfolio	0.00% 4.4M shares	Q1 2023 Held for 2y 8m	$218.74B
Deep Track Capital, LP Hedge Fund•Long/Short	David Eric Kroin CIO	$118.0M 3.36% of portfolio	0.00% 4.2M shares	Q2 2025 Held for 5 months	$3.5B
B BVF INC/IL Institution	-	$89.7M 3.64% of portfolio	0.00% 3.2M shares	Q4 2023 Held for 1y 11m	$2.5B
B BAKER BROS. ADVISORS LP Hedge Fund•Sector	Scott Lawrence Lessing President	$43.6M 0.40% of portfolio	0.00% 1.6M shares	Q3 2024 Held for 1y 2m	$10.8B
RA CAPITAL MANAGEMENT, LLC Hedge Fund•Long/Short	Michael Saulnier CFO	$42.5M 0.53% of portfolio	0.00% 1.5M shares	Q4 2023 Held for 1y 11m	$8.1B
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	Dan Michael Berkovitz Chairman	$35.7M 0.03% of portfolio	0.00% 1.3M shares	Q2 2023 Held for 2y 5m	$121.98B
AMERIPRISE FINANCIAL INC Institution	Jim Cracchiolo CEO	$34.3M 0.01% of portfolio	0.00% 1.2M shares	Q4 2023 Held for 1y 11m	$433.11B

Net Capital Flow

Institutional buying and selling activity for GPCR in Q3 2025

Traded: +$117.6M
Buyers: 67
Sellers: 76
Total Bought: +$337.7M
Total Sold: −$220.2M
Avg Position: $8.7M

Biggest Buyers

Institution	Net Bought	Current Position
venBio Select Advisor LLC RIA/Wealth	+$144.4M +5.2M shares	$144.4M 5.2M shares
B BVF INC/IL Institution	+$40.1M +1.4M shares	$89.7M 3.2M shares
S Siren, L.L.C. Institution	+$28.8M +1.0M shares	$28.8M 1.0M shares
BALYASNY ASSET MANAGEMENT LLC Hedge Fund•Multi-Strategy	+$12.9M +461.6K shares	$12.9M 461.6K shares
Paradigm Biocapital Advisors LP Hedge Fund•Long/Short	+$10.4M +372.9K shares	$10.4M 372.9K shares
FMR LLC Institution	+$9.4M +335.4K shares	$147.0M 5.3M shares
GOLDMAN SACHS GROUP INC Institution	+$8.0M +284.2K shares	$14.1M 504.4K shares
A Alyeska Investment Group, L.P. Hedge Fund•Multi-Strategy	+$6.9M +244.8K shares	$6.9M 244.8K shares
TWO SIGMA ADVISERS, LLC Hedge Fund•Multi-Strategy	+$6.0M +213.2K shares	$7.0M 249.3K shares
DRIEHAUS CAPITAL MANAGEMENT LLC Hedge Fund•Event Driven	+$5.6M +200.7K shares	$24.5M 873.5K shares

Biggest Sellers

Institution	Net Sold	Current Position
C Capital International Investors Institution	−$33.6M −1.6M shares	Sold Off 0 shares
WELLINGTON MANAGEMENT CO LLP Long Only Manager	−$33.2M −1.2M shares	$159.3M 5.7M shares
B BAKER BROS. ADVISORS LP Hedge Fund•Sector	−$26.7M −952.7K shares	$43.6M 1.6M shares
Deep Track Capital, LP Hedge Fund•Long/Short	−$25.7M −918.1K shares	$118.0M 4.2M shares
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	−$24.8M −884.7K shares	$12.4M 443.8K shares
AMERIPRISE FINANCIAL INC Institution	−$10.2M −364.1K shares	$34.3M 1.2M shares
MORGAN STANLEY RIA/Wealth	−$9.5M −339.6K shares	$16.2M 577.7K shares
Schonfeld Strategic Advisors LLC Hedge Fund•Multi-Strategy	−$6.7M −321.6K shares	Sold Off 0 shares
Rock Springs Capital Management LP Hedge Fund•Sector	−$5.2M −184.7K shares	$26.6M 951.2K shares
Foresite Capital Management VI LLC Venture Capital	−$4.4M −210.0K shares	Sold Off 0 shares

Entry and Exit Activity

Institutions that initiated new positions or completely exited GPCR in Q3 2025

New Positions: 14
New Value: $49.9M
Exited Positions: 37
Exited Value: $64.1M

New Positions

Institution	Position Value
S Siren, L.L.C. Institution	$28.8M 1.0M shares
Paradigm Biocapital Advisors LP Hedge Fund•Long/Short	$10.4M 372.9K shares
TWO SIGMA INVESTMENTS LLC Hedge Fund•Multi-Strategy	$5.1M 182.9K shares
StemPoint Capital LP Hedge Fund•Long/Short	$3.6M 129.3K shares
P Private Capital Advisors, Inc. RIA/Wealth	$1.5M 55.2K shares
M MISSION WEALTH MANAGEMENT, LLC Institution	$268.3K 9.6K shares
BARCLAYS PLC Institution	$105.6K 3.8K shares
Rockefeller Capital Management L.P. Long Only Manager	$20.8K 742.0 shares
L LEGAL & GENERAL GROUP PLC Institution	$17.1K 612.0 shares
H HighMark Wealth Management LLC RIA/Wealth	$11.7K 418.0 shares

Exited Positions

Institution	Previous Position
C Capital International Investors Institution	$33.6M 1.6M shares
Schonfeld Strategic Advisors LLC Hedge Fund•Multi-Strategy	$6.7M 321.6K shares
Foresite Capital Management VI LLC Venture Capital	$4.4M 210.0K shares
Marshall Wace LLP Institution	$3.7M 176.1K shares
SILVERARC CAPITAL MANAGEMENT, LLC Hedge Fund•Long/Short	$3.6M 175.6K shares
C CANADA PENSION PLAN INVESTMENT BOARD Institution	$3.5M 167.8K shares
Jain Global LLC Hedge Fund•Multi-Strategy	$1.4M 69.4K shares
Exome Asset Management LLC Hedge Fund•Sector	$1.1M 53.7K shares
S Sofinnova Ventures Inc Venture Capital	$712.5K 34.4K shares
D DCF Advisers, LLC Institution	$513.3K 24.8K shares

Options Activity

Institutions with the largest Call and Put options positions in GPCR as of Q3 2025

Call Positions: 8
Call Value: $23.4M
Put Positions: 4
Put Value: $7.8M

Call Positions

Institution	Position Value
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$6.6M 2.4K contracts
Caption Management, LLC Hedge Fund•Long/Short	$5.2M 1.9K contracts
Walleye Trading LLC RIA/Wealth	$3.2M 1.1K contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$3.1M 1.1K contracts
venBio Select Advisor LLC RIA/Wealth	$2.2M 2.5K contracts
DLD Asset Management, LP Hedge Fund•Multi-Strategy	$1.6M 558.0 contracts
J JANE STREET GROUP, LLC Institution	$901.6K 322.0 contracts
UBS Group AG Institution	$590.8K 211.0 contracts

Put Positions

Institution	Position Value
Caption Management, LLC Hedge Fund•Long/Short	$4.5M 1.6K contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$2.3M 834.0 contracts
Walleye Trading LLC RIA/Wealth	$736.4K 263.0 contracts
Walleye Trading Advisors, LLC Hedge Fund•Multi-Strategy	$229.6K 82.0 contracts

Most Committed Institutions

Institutions with GPCR as the highest % of their portfolio as of Q3 2025

Institution	Key People	Portfolio Weight	Ownership	Owned Since	Total AUM (Long)
SECTORAL ASSET MANAGEMENT INC Venture Capital	Jerome Georges Pfund CEO	3.89% $6.2M	0.00% 221.9K shares	Q4 2023 Held for 1y 11m	$159.6M
B BVF INC/IL Institution	-	3.64% $89.7M	0.00% 3.2M shares	Q4 2023 Held for 1y 11m	$2.5B
Catalio Capital Management, LP Venture Capital	Olga Eduardovna Maltseva COO	3.37% $18.3M	0.00% 651.8K shares	Q4 2024 Held for 11 months	$540.9M
Deep Track Capital, LP Hedge Fund•Long/Short	David Eric Kroin CIO	3.36% $118.0M	0.00% 4.2M shares	Q2 2025 Held for 5 months	$3.5B
venBio Select Advisor LLC RIA/Wealth	Behzad Aghazadeh Managing Partner	1.87% $144.4M	0.00% 5.2M shares	Q3 2025 Held for 2 months	$7.7B
HighVista Strategies LLC Fund of Funds	Richard P Vishton CFO	1.60% $6.6M	0.00% 236.2K shares	Q3 2023 Held for 2y 2m	$413.3M
Rock Springs Capital Management LP Hedge Fund•Sector	Nnamdi C Etoh CFO	1.56% $26.6M	0.00% 951.2K shares	Q4 2023 Held for 1y 11m	$1.7B
S Siren, L.L.C. Institution	-	1.21% $28.8M	0.00% 1.0M shares	Q3 2025 Held for 2 months	$2.4B
S SPHERA FUNDS MANAGEMENT LTD. Institution	-	1.17% $4.9M	0.00% 173.9K shares	Q1 2025 Held for 8 months	$416.3M
Ikarian Capital, LLC Hedge Fund•Event Driven	Neil Tristan Shahrestani CEO	0.92% $4.6M	0.00% 163.2K shares	Q3 2023 Held for 2y 2m	$494.3M

Hedge Fund Spotlight

Discover hedge funds investing in GPCR

DRIEHAUS CAPITAL MANAGEMENT LLC

Hedge Fund • Event Driven

Portfolio ManagerStephen Thomas Weber

Portfolio Value: $13.9B
Positions: 419
Last Reported: Q3 2025

Sector Allocation

Position in Structure Therapeutics

Market Value: $24.5M
Shares Held: 873.5K
Portfolio Weight: 0.18%
Owned Since: 2023-Q1

Top Holding	Sector	Market Value	Weight
1 Taiwan Semiconductor Manufacturing Company TSM	Semiconductors Technology	$626.6M	4.49%
2 Crinetics Pharmaceuticals CRNX	Biotechnology Healthcare	$270.0M	1.94%
3 Planet Labs PL	Aerospace & Defense Industrials	$186.6M	1.34%