ALX Oncology Holdings Inc.

ALXO • NASDAQ

ALX Oncology Holdings Inc. is a biotechnology company in the healthcare sector on NASDAQ, led by Jason Lettmann, with a market cap of $79.7M. As of Q3 2025, 52% of shares are held by 60 institutional investors, with venBio Partners LLC as the largest holder at 18.11%.

Chief Executive OfficerJason Lettmann

Market Cap$79.7M

Biotechnology

Healthcare

Employees74.0

Websitealxoncology.com

Country

United States of America

Overview

Overview of institutional ownership in ALXO as of Q3 2025 with a market cap of $98.0M

All Institutions

Institutions: 60
Value Held: $50.8M
Shares Held: 27.8M
Avg Position: $847.4K
Median Position: $67.8K

Hedge Funds

Hedge Funds: 8
Value Held: $15.3M
Shares Held: 8.3M
Avg Position: $1.9M
Median Position: $1.2M

Ownership Breakdown

Institutional (non-HF)

36.31%

$35.6M

Hedge Funds

15.58%

$15.3M

Retail & Other

48.11%

$47.2M

Based on market cap of $98.0M as of Q3 2025. Institutional (non-HF) excludes hedge funds to avoid double counting.

Biggest Investors

Institutions with the largest positions in ALXO as of Q3 2025

Institution	Key People	Position Value	Ownership	Owned Since	Total AUM (Long)
V venBio Partners LLC Institution	-	$17.8M 10.06% of portfolio	18.11% 9.7M shares	Q3 2020 Held for 5y 2m	$176.4M
R Redmile Group, LLC Hedge Fund•Sector	Amrit Nmn Nagpal Managing Partner	$6.1M 0.59% of portfolio	6.22% 3.3M shares	Q3 2020 Held for 5y 2m	$1.0B
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	Dan Michael Berkovitz Chairman	$4.8M 0.00% of portfolio	4.90% 2.6M shares	Q1 2021 Held for 4y 8m	$121.98B
Almitas Capital LLC RIA/Wealth	Ronald Dean Mass Managing Partner	$4.6M 1.07% of portfolio	4.74% 2.5M shares	Q4 2024 Held for 11 months	$435.9M
VANGUARD GROUP INC Institution	Salim Ramji CEO	$2.8M 0.00% of portfolio	2.85% 1.5M shares	Q3 2020 Held for 5y 2m	$6.69T
ACADIAN ASSET MANAGEMENT LLC Long Only Manager	Gillian Morna Therese Savage CEO	$2.2M 0.00% of portfolio	2.28% 1.2M shares	Q3 2024 Held for 1y 2m	$51.5B
DRIEHAUS CAPITAL MANAGEMENT LLC Hedge Fund•Event Driven	Stephen Thomas Weber CEO	$1.5M 0.01% of portfolio	1.49% 795.8K shares	Q3 2025 Held for 2 months	$13.9B
TWO SIGMA ADVISERS, LLC Hedge Fund•Multi-Strategy	Scott David Hoffman CEO	$1.3M 0.00% of portfolio	1.34% 719.8K shares	Q4 2021 Held for 3y 11m	$50.0B
AMERIPRISE FINANCIAL INC Institution	Jim Cracchiolo CEO	$1.2M 0.00% of portfolio	1.22% 652.9K shares	Q3 2025 Held for 2 months	$433.11B
TWO SIGMA INVESTMENTS LLC Hedge Fund•Multi-Strategy	Scott David Hoffman CEO	$1.1M 0.00% of portfolio	1.13% 606.7K shares	Q4 2023 Held for 1y 11m	$62.0B

Net Capital Flow

Institutional buying and selling activity for ALXO in Q3 2025

Traded: +$2.9M
Buyers: 17
Sellers: 39
Total Bought: +$7.4M
Total Sold: −$4.4M
Avg Position: $736.9K

Biggest Buyers

Institution	Net Bought	Current Position
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	+$3.9M +2.1M shares	$4.8M 2.6M shares
DRIEHAUS CAPITAL MANAGEMENT LLC Hedge Fund•Event Driven	+$1.5M +795.8K shares	$1.5M 795.8K shares
AMERIPRISE FINANCIAL INC Institution	+$1.2M +652.9K shares	$1.2M 652.9K shares
TWO SIGMA INVESTMENTS LLC Hedge Fund•Multi-Strategy	+$235.6K +128.7K shares	$1.1M 606.7K shares
IEQ CAPITAL, LLC RIA/Wealth	+$168.8K +92.2K shares	$168.8K 92.2K shares
RENAISSANCE TECHNOLOGIES LLC Hedge Fund•Quant	+$144.8K +79.1K shares	$301.0K 164.5K shares
GEODE CAPITAL MANAGEMENT LLC ETF Provider	+$67.6K +36.9K shares	$645.0K 352.3K shares
B BRIDGEWAY CAPITAL MANAGEMENT INC Long Only Manager	+$65.9K +36.0K shares	$65.9K 36.0K shares
H HRT FINANCIAL LLC Institution	+$41.2K +22.5K shares	$41.2K 22.5K shares
GOLDMAN SACHS GROUP INC Institution	+$34.0K +-271.1K shares	$34.0K 18.6K shares

Biggest Sellers

Institution	Net Sold	Current Position
T TANG CAPITAL MANAGEMENT LLC Institution	−$1.3M −3.2M shares	Sold Off 0 shares
BANK OF AMERICA CORP /DE/ Institution	−$922.9K −504.3K shares	$971.4K 530.8K shares
B BlackRock, Inc. Institution	−$491.5K −268.6K shares	$819.3K 447.7K shares
BANK OF MONTREAL /CAN/ Institution	−$355.0K −194.0K shares	$868.8K 474.8K shares
UBS Group AG Institution	−$212.5K −116.1K shares	$315.8K 172.6K shares
VANGUARD GROUP INC Institution	−$132.1K −72.2K shares	$2.8M 1.5M shares
Marshall Wace LLP Institution	−$122.1K −66.7K shares	$72.4K 39.6K shares
R Redmile Group, LLC Hedge Fund•Sector	−$107.0K −58.5K shares	$6.1M 3.3M shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	−$92.9K −50.8K shares	$206.9K 113.1K shares
X XTX Topco Ltd Institution	−$88.1K −48.1K shares	$48.7K 26.6K shares

Entry and Exit Activity

Institutions that initiated new positions or completely exited ALXO in Q3 2025

New Positions: 4
New Value: $1.6M
Exited Positions: 8
Exited Value: $1.4M

New Positions

Institution	Position Value
DRIEHAUS CAPITAL MANAGEMENT LLC Hedge Fund•Event Driven	$1.5M 795.8K shares
IEQ CAPITAL, LLC RIA/Wealth	$168.8K 92.2K shares
O Optiver Holding B.V. Institution	$51.0 28.0 shares
SRS Capital Advisors, Inc. RIA/Wealth	$3.0 2.0 shares

Exited Positions

Institution	Previous Position
T TANG CAPITAL MANAGEMENT LLC Institution	$1.3M 3.2M shares
SCHWAB CHARLES INVESTMENT MANAGEMENT INC Long Only Manager	$55.4K 133.4K shares
S Squarepoint Ops LLC Hedge Fund•Quant	$24.2K 58.3K shares
G GROUP ONE TRADING, L.P. Institution	$2.2K 5.2K shares
RAYMOND JAMES FINANCIAL INC RIA/Wealth	$415.0 1.0K shares
WELLS FARGO & COMPANY/MN Institution	$186.0 447.0 shares
Hartland & Co., LLC RIA/Wealth	$74.0 177.0 shares
True Wealth Design, LLC RIA/Wealth	$7.0 15.0 shares

Options Activity

Institutions with the largest Call and Put options positions in ALXO as of Q3 2025

Call Positions: 3
Call Value: $315.9K
Put Positions: 1
Put Value: -

Call Positions

Institution	Position Value
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$135.8K 742.0 contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$105.2K 575.0 contracts
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	$74.8K 409.0 contracts

Put Positions

Institution	Position Value
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	- - contracts

Most Committed Institutions

Institutions with ALXO as the highest % of their portfolio as of Q3 2025

Institution	Key People	Portfolio Weight	Ownership	Owned Since	Total AUM (Long)
V venBio Partners LLC Institution	-	10.06% $17.8M	18.11% 9.7M shares	Q3 2020 Held for 5y 2m	$176.4M
Almitas Capital LLC RIA/Wealth	Ronald Dean Mass Managing Partner	1.07% $4.6M	4.74% 2.5M shares	Q4 2024 Held for 11 months	$435.9M
R Redmile Group, LLC Hedge Fund•Sector	Amrit Nmn Nagpal Managing Partner	0.59% $6.1M	6.22% 3.3M shares	Q3 2020 Held for 5y 2m	$1.0B
P Privium Fund Management B.V. Institution	-	0.17% $931.6K	0.95% 509.1K shares	Q2 2024 Held for 1y 5m	$556.3M
H HC Advisors, LLC RIA/Wealth	Daniel Christopher Henning CEO	0.03% $40.0K	0.04% 21.9K shares	Q3 2024 Held for 1y 2m	$142.3M
GSA CAPITAL PARTNERS LLP Hedge Fund•Quant	David Khabie-Zeitoune CEO	0.01% $161.3K	0.16% 88.2K shares	Q2 2025 Held for 5 months	$1.1B
DRIEHAUS CAPITAL MANAGEMENT LLC Hedge Fund•Event Driven	Stephen Thomas Weber CEO	0.01% $1.5M	1.49% 795.8K shares	Q3 2025 Held for 2 months	$13.9B
A Abel Hall, LLC RIA/Wealth	Leo Gregory Abel Managing Partner	0.01% $23.1K	0.02% 12.6K shares	Q4 2024 Held for 11 months	$246.5M
NAN FUNG TRINITY Ltd RIA/Wealth	Fredric Brian Fisher President	0.01% $76.8K	0.08% 42.0K shares	Q2 2025 Held for 5 months	$1.0B
JSF Financial, LLC RIA/Wealth	Jeffrey Seth Fishman Managing Partner	0.01% $32.0K	0.03% 17.5K shares	Q4 2024 Held for 11 months	$450.8M

Hedge Fund Spotlight

Discover hedge funds investing in ALXO

DRIEHAUS CAPITAL MANAGEMENT LLC

Hedge Fund • Event Driven

Portfolio ManagerStephen Thomas Weber

Portfolio Value: $13.9B
Positions: 419
Last Reported: Q3 2025

Sector Allocation

Position in ALX Oncology Holdings Inc.

Market Value: $1.5M
Shares Held: 795.8K
Portfolio Weight: 0.01%
Owned Since: 2025-Q3

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