Crinetics Pharmaceuticals

CRNX • NASDAQ

Crinetics Pharmaceuticals is a biotechnology company in the healthcare sector on NASDAQ, led by R. Scott Struthers, with a market cap of $4.8B. As of Q3 2025, 114% of shares are held by 222 institutional investors, with FMR LLC as the largest holder at 15.06%.

CEOR. Scott Struthers

Market Cap$4.8B

Biotechnology

Healthcare

Employees210.0

Websitecrinetics.com

Country

United States of America

Overview

Overview of institutional ownership in CRNX as of Q3 2025 with a market cap of $3.9B

All Institutions

Institutions: 222
Value Held: $4.5B
Shares Held: 107.7M
Avg Position: $20.2M
Median Position: $934.2K

Hedge Funds

Hedge Funds: 31
Value Held: $1.2B
Shares Held: 28.2M
Avg Position: $38.0M
Median Position: $9.0M

Ownership Breakdown

Institutional (non-HF)

84.36%

$3.3B

Hedge Funds

29.99%

$1.2B

Retail & Other

Based on market cap of $3.9B as of Q3 2025. Institutional (non-HF) excludes hedge funds to avoid double counting.

Biggest Investors

Institutions with the largest positions in CRNX as of Q3 2025

Institution	Key People	Position Value	Ownership	Owned Since	Total AUM (Long)
FMR LLC Institution	-	$590.9M 0.03% of portfolio	15.06% 14.2M shares	Q3 2018 Held for 7y 2m	$1.92T
VANGUARD GROUP INC Institution	Salim Ramji CEO	$381.9M 0.01% of portfolio	9.74% 9.2M shares	Q3 2018 Held for 7y 2m	$6.69T
WELLINGTON MANAGEMENT CO LLP Long Only Manager	Jean Marie Hynes CEO	$349.1M 0.06% of portfolio	8.90% 8.4M shares	Q2 2020 Held for 5y 5m	$571.21B
B BlackRock, Inc. Institution	-	$316.0M 0.01% of portfolio	8.06% 7.6M shares	Q3 2018 Held for 7y 2m	$5.67T
DRIEHAUS CAPITAL MANAGEMENT LLC Hedge Fund•Event Driven	Stephen Thomas Weber CEO	$270.0M 1.94% of portfolio	6.88% 6.5M shares	Q2 2020 Held for 5y 5m	$13.9B
FARALLON CAPITAL MANAGEMENT LLC Hedge Fund•Multi-Strategy	Edric Calvin Saito Managing Partner	$240.3M 1.36% of portfolio	6.13% 5.8M shares	Q3 2023 Held for 2y 2m	$17.7B
PRICE T ROWE ASSOCIATES INC /MD/ Long Only Manager	Robert W Sharps President	$221.0M 0.02% of portfolio	5.63% 5.3M shares	Q3 2018 Held for 7y 2m	$912.31B
EcoR1 Capital, LLC Hedge Fund•Sector	Scott Eric Perlen CFO	$178.6M 8.57% of portfolio	4.55% 4.3M shares	Q4 2021 Held for 3y 11m	$2.1B
HENDERSON GROUP PLC Institution	Ali Dibadj CEO	$160.7M 0.07% of portfolio	4.10% 3.9M shares	Q3 2022 Held for 3y 2m	$218.74B
Paradigm Biocapital Advisors LP Hedge Fund•Long/Short	Dr. Senai Nmn Asefaw CIO	$106.2M 3.14% of portfolio	2.71% 2.6M shares	Q3 2022 Held for 3y 2m	$3.4B

Net Capital Flow

Institutional buying and selling activity for CRNX in Q3 2025

Traded: +$217.6M
Buyers: 130
Sellers: 101
Total Bought: +$427.4M
Total Sold: −$209.9M
Avg Position: $17.5M

Biggest Buyers

Institution	Net Bought	Current Position
WELLINGTON MANAGEMENT CO LLP Long Only Manager	+$107.2M +2.6M shares	$349.1M 8.4M shares
FARALLON CAPITAL MANAGEMENT LLC Hedge Fund•Multi-Strategy	+$46.8M +1.1M shares	$240.3M 5.8M shares
JPMORGAN CHASE & CO Institution	+$38.6M +926.8K shares	$52.4M 1.3M shares
HENDERSON GROUP PLC Institution	+$18.7M +448.5K shares	$160.7M 3.9M shares
RTW INVESTMENTS, LLC Hedge Fund•Sector	+$16.9M +405.4K shares	$36.3M 872.4K shares
AMERIPRISE FINANCIAL INC Institution	+$15.7M +376.2K shares	$25.6M 614.8K shares
A AMERICAN CENTURY COMPANIES INC Institution	+$11.9M +284.9K shares	$47.2M 1.1M shares
Pictet Asset Management Holding SA Long Only Manager	+$11.0M +264.8K shares	$61.0M 1.5M shares
Checkpoint Capital L.P. Hedge Fund•Sector	+$10.8M +260.0K shares	$10.8M 260.0K shares
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	+$9.6M +230.9K shares	$36.8M 884.5K shares

Biggest Sellers

Institution	Net Sold	Current Position
STATE STREET CORP Institution	−$42.3M −1.0M shares	$92.0M 2.2M shares
Vestal Point Capital, LP Hedge Fund•Long/Short	−$31.2M −750.0K shares	$31.2M 750.0K shares
Ikarian Capital, LLC Hedge Fund•Event Driven	−$12.6M −302.5K shares	$5.5M 130.9K shares
MPM Oncology Impact Management LP Institution	−$12.3M −429.0K shares	Sold Off 0 shares
PRICE T ROWE ASSOCIATES INC /MD/ Long Only Manager	−$11.8M −284.3K shares	$221.0M 5.3M shares
M M&G Plc Institution	−$8.2M −281.9K shares	Sold Off 0 shares
GOLDMAN SACHS GROUP INC Institution	−$7.8M −187.8K shares	$29.7M 713.1K shares
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	−$5.9M −141.4K shares	$9.0M 216.2K shares
Q Qube Research & Technologies Ltd Institution	−$5.7M −198.9K shares	Sold Off 0 shares
Walleye Trading Advisors, LLC Hedge Fund•Multi-Strategy	−$5.5M −190.4K shares	Sold Off 0 shares

Entry and Exit Activity

Institutions that initiated new positions or completely exited CRNX in Q3 2025

New Positions: 22
New Value: $37.3M
Exited Positions: 34
Exited Value: $42.2M

New Positions

Institution	Position Value
Checkpoint Capital L.P. Hedge Fund•Sector	$10.8M 260.0K shares
Sio Capital Management, LLC Hedge Fund•Long/Short	$7.3M 174.8K shares
R RICE HALL JAMES & ASSOCIATES, LLC Long Only Manager	$7.3M 174.1K shares
W Winton Capital Group Ltd Institution	$2.8M 68.2K shares
N Neuberger Berman Group LLC Institution	$2.8M 67.1K shares
Phocas Financial Corp. Long Only Manager	$2.2M 54.0K shares
Weiss Asset Management LP Hedge Fund•Multi-Strategy	$1.4M 34.0K shares
P Point72 Asia Pte. Ltd. Institution	$536.8K 12.9K shares
A Assenagon Asset Management S.A. Institution	$513.9K 12.3K shares
JustInvest LLC Long Only Manager	$311.8K 7.5K shares

Exited Positions

Institution	Previous Position
MPM Oncology Impact Management LP Institution	$12.3M 429.0K shares
M M&G Plc Institution	$8.2M 281.9K shares
Q Qube Research & Technologies Ltd Institution	$5.7M 198.9K shares
Walleye Trading Advisors, LLC Hedge Fund•Multi-Strategy	$5.5M 190.4K shares
Verition Fund Management LLC Hedge Fund•Multi-Strategy	$2.7M 95.3K shares
Exome Asset Management LLC Hedge Fund•Sector	$1.8M 62.7K shares
S Squarepoint Ops LLC Hedge Fund•Quant	$1.2M 42.1K shares
UBS OCONNOR LLC Long Only Manager	$1.1M 40.0K shares
X XTX Topco Ltd Institution	$978.2K 34.0K shares
SPRINGBOK CAPITAL MANAGEMENT, LLC Fund of Funds	$527.1K 18.3K shares

Options Activity

Institutions with the largest Call and Put options positions in CRNX as of Q3 2025

Call Positions: 6
Call Value: $42.6M
Put Positions: 4
Put Value: $8.5M

Call Positions

Institution	Position Value
Ikarian Capital, LLC Hedge Fund•Event Driven	$10.7M 2.6K contracts
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$10.2M 2.4K contracts
Caption Management, LLC Hedge Fund•Long/Short	$7.8M 1.9K contracts
J JANE STREET GROUP, LLC Institution	$5.4M 1.3K contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$4.5M 1.1K contracts
BOOTHBAY FUND MANAGEMENT, LLC Fund of Funds	$3.9M 940.0 contracts

Put Positions

Institution	Position Value
ORBIMED ADVISORS LLC Hedge Fund•Sector	$4.2M 1.0K contracts
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$1.9M 450.0 contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$1.6M 382.0 contracts
J JANE STREET GROUP, LLC Institution	$866.3K 208.0 contracts

Most Committed Institutions

Institutions with CRNX as the highest % of their portfolio as of Q3 2025

Institution	Key People	Portfolio Weight	Ownership	Owned Since	Total AUM (Long)
New Leaf Venture Partners, L.L.C. Venture Capital	Vijay Kiran Lathi Managing Partner	13.64% $5.9M	0.15% 141.0K shares	Q3 2018 Held for 7y 2m	$43.0M
EcoR1 Capital, LLC Hedge Fund•Sector	Scott Eric Perlen CFO	8.57% $178.6M	4.55% 4.3M shares	Q4 2021 Held for 3y 11m	$2.1B
Checkpoint Capital L.P. Hedge Fund•Sector	Tony Michael Berta CFO	5.77% $10.8M	0.28% 260.0K shares	Q3 2025 Held for 2 months	$187.8M
N Novo A/S Institution	-	4.44% $67.7M	1.73% 1.6M shares	Q1 2022 Held for 3y 8m	$1.5B
First Light Asset Management, LLC Hedge Fund•Sector	Mathew Paul Arens CEO	3.70% $39.2M	1.00% 941.5K shares	Q4 2021 Held for 3y 11m	$1.1B
Prosight Management, LP Hedge Fund•Long/Short	William Lawrence Hawkins Managing Partner	3.63% $13.7M	0.35% 328.7K shares	Q2 2025 Held for 5 months	$376.7M
Paradigm Biocapital Advisors LP Hedge Fund•Long/Short	Dr. Senai Nmn Asefaw CIO	3.14% $106.2M	2.71% 2.6M shares	Q3 2022 Held for 3y 2m	$3.4B
S Siren, L.L.C. Institution	-	2.95% $70.3M	1.79% 1.7M shares	Q3 2024 Held for 1y 2m	$2.4B
DRIEHAUS CAPITAL MANAGEMENT LLC Hedge Fund•Event Driven	Stephen Thomas Weber CEO	1.94% $270.0M	6.88% 6.5M shares	Q2 2020 Held for 5y 5m	$13.9B
Sio Capital Management, LLC Hedge Fund•Long/Short	Judah Zvi Drillick CEO	1.84% $7.3M	0.19% 174.8K shares	Q3 2025 Held for 2 months	$395.2M

Hedge Fund Spotlight

Discover hedge funds investing in CRNX

Quest Partners LLC

Hedge Fund • Quant Macro

Portfolio ManagerNigol (Nmn) Koulajian

Portfolio Value: $1.5B
Positions: 2,240
Last Reported: Q3 2025

Sector Allocation

Position in Crinetics Pharmaceuticals

Market Value: $612.6K
Shares Held: 14.7K
Portfolio Weight: 0.04%
Owned Since: 2024-Q2

Top Holding	Sector	Market Value	Weight
1 iShares 7-10 Year Treasury Bond IEF	ETF ETF	$39.0M	2.54%
2 SPDR Portfolio Intermediate Term Treasury SPTI	ETF ETF	$6.5M	0.42%
3 SCHR Schwab Intermediately-Term U.S. Treasury SCHR	ETF ETF	$6.5M	0.42%

View full profile

Crinetics Pharmaceuticals

Overview

All Institutions

Hedge Funds

Ownership Breakdown

Biggest Investors

Net Capital Flow

Biggest Buyers

Biggest Sellers

Entry and Exit Activity

New Positions

Exited Positions

Options Activity

Call Positions

Put Positions

Most Committed Institutions

Hedge Fund Spotlight

Position in Crinetics Pharmaceuticals

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