Cytokinetics

CYTK • NASDAQ

Cytokinetics is a biotechnology company in the healthcare sector on NASDAQ, led by Robert M. Califf, with a market cap of $7.7B. As of Q3 2025, 118% of shares are held by 373 institutional investors, with T. Rowe Price Investment Management, Inc. as the largest holder at 15.95%.

CEORobert M. Califf

Market Cap$7.7B

Biotechnology

Healthcare

Employees564.0

Websitecytokinetics.com

Country

United States of America

Overview

Overview of institutional ownership in CYTK as of Q3 2025 with a market cap of $6.6B

All Institutions

Institutions: 373
Value Held: $7.7B
Shares Held: 141.0M
Avg Position: $20.8M
Median Position: $1.3M

Hedge Funds

Hedge Funds: 60
Value Held: $1.1B
Shares Held: 20.9M
Avg Position: $19.1M
Median Position: $5.6M

Ownership Breakdown

Institutional (non-HF)

100.36%

$6.6B

Hedge Funds

17.45%

$1.1B

Retail & Other

Based on market cap of $6.6B as of Q3 2025. Institutional (non-HF) excludes hedge funds to avoid double counting.

Biggest Investors

Institutions with the largest positions in CYTK as of Q3 2025

Institution	Key People	Position Value	Ownership	Owned Since	Total AUM (Long)
T T. Rowe Price Investment Management, Inc. Insurance Manager	John Edward Robison President	$1.0B 0.65% of portfolio	15.95% 19.1M shares	Q4 2022 Held for 2y 11m	$161.58B
B BlackRock, Inc. Institution	-	$853.3M 0.02% of portfolio	12.98% 15.5M shares	Q3 2013 Held for 12y 2m	$5.67T
FMR LLC Institution	-	$719.5M 0.04% of portfolio	10.94% 13.1M shares	Q3 2013 Held for 12y 2m	$1.92T
VANGUARD GROUP INC Institution	Salim Ramji CEO	$651.6M 0.01% of portfolio	9.91% 11.9M shares	Q3 2013 Held for 12y 2m	$6.69T
WELLINGTON MANAGEMENT CO LLP Long Only Manager	Jean Marie Hynes CEO	$407.2M 0.07% of portfolio	6.19% 7.4M shares	Q2 2020 Held for 5y 5m	$571.21B
STATE STREET CORP Institution	Ronald P. O'Hanley CEO	$308.7M 0.01% of portfolio	4.69% 5.6M shares	≤ Q2 2013 Held for 12y 5m+	$2.88T
Deep Track Capital, LP Hedge Fund•Long/Short	David Eric Kroin CIO	$236.3M 6.72% of portfolio	3.59% 4.3M shares	Q4 2023 Held for 1y 11m	$3.5B
BANK OF AMERICA CORP /DE/ Institution	Brian T. Moynihan CEO	$168.3M 0.01% of portfolio	2.56% 3.1M shares	Q3 2013 Held for 12y 2m	$1.33T
GEODE CAPITAL MANAGEMENT LLC ETF Provider	David Kenneth Lane CEO	$167.1M 0.01% of portfolio	2.54% 3.0M shares	≤ Q2 2013 Held for 12y 5m+	$1.57T
Polar Capital Holdings Plc Long Only Manager	Gavin Mark Rochussen CEO	$152.9M 0.74% of portfolio	2.33% 2.8M shares	Q4 2020 Held for 4y 11m	$20.8B

Net Capital Flow

Institutional buying and selling activity for CYTK in Q3 2025

Traded: +$299.3M
Buyers: 224
Sellers: 123
Total Bought: +$860.4M
Total Sold: −$561.0M
Avg Position: $19.6M

Biggest Buyers

Institution	Net Bought	Current Position
FMR LLC Institution	+$100.3M +1.8M shares	$719.5M 13.1M shares
T T. Rowe Price Investment Management, Inc. Insurance Manager	+$81.2M +1.5M shares	$1.0B 19.1M shares
Woodline Partners LP Hedge Fund•Long/Short	+$78.9M +1.4M shares	$90.6M 1.6M shares
Deep Track Capital, LP Hedge Fund•Long/Short	+$35.7M +650.0K shares	$236.3M 4.3M shares
PRICE T ROWE ASSOCIATES INC /MD/ Long Only Manager	+$27.5M +500.9K shares	$130.1M 2.4M shares
Point72 Asset Management, L.P. Hedge Fund•Multi-Strategy	+$25.9M +471.5K shares	$25.9M 471.5K shares
Foresite Capital Management IV, LLC Venture Capital	+$25.2M +458.3K shares	$25.2M 458.3K shares
BANK OF AMERICA CORP /DE/ Institution	+$22.9M +416.2K shares	$168.3M 3.1M shares
MORGAN STANLEY RIA/Wealth	+$22.2M +403.1K shares	$83.6M 1.5M shares
Integral Health Asset Management, LLC Hedge Fund•Sector	+$22.0M +400.0K shares	$76.9M 1.4M shares

Biggest Sellers

Institution	Net Sold	Current Position
Vestal Point Capital, LP Hedge Fund•Long/Short	−$123.7M −2.3M shares	$39.8M 725.0K shares
UBS Group AG Institution	−$69.7M −1.3M shares	$99.1M 1.8M shares
ALLIANCEBERNSTEIN L.P. Long Only Manager	−$63.2M −1.2M shares	$12.9M 235.4K shares
STATE STREET CORP Institution	−$41.5M −755.4K shares	$308.7M 5.6M shares
ORBIMED ADVISORS LLC Hedge Fund•Sector	−$35.6M −1.1M shares	Sold Off 0 shares
Melqart Asset Management Ltd Hedge Fund•Multi-Strategy	−$29.8M −542.9K shares	$43.1M 783.8K shares
WELLINGTON MANAGEMENT CO LLP Long Only Manager	−$23.0M −419.1K shares	$407.2M 7.4M shares
Pictet Asset Management Holding SA Long Only Manager	−$22.0M −400.8K shares	$62.9M 1.1M shares
E Ensign Peak Advisors, Inc Institution	−$10.1M −183.5K shares	$1.1M 20.5K shares
UBS GLOBAL ASSET MANAGEMENT AMERICAS INC Long Only Manager	−$9.8M −177.9K shares	$13.1M 238.4K shares

Entry and Exit Activity

Institutions that initiated new positions or completely exited CYTK in Q3 2025

New Positions: 34
New Value: $41.6M
Exited Positions: 23
Exited Value: $57.6M

New Positions

Institution	Position Value
Boxer Capital Management, LLC Hedge Fund•Long/Short	$11.0M 200.0K shares
GANNETT WELSH & KOTLER Long Only Manager	$9.9M 180.7K shares
Weiss Asset Management LP Hedge Fund•Multi-Strategy	$3.5M 64.2K shares
R Resolute Capital Asset Partners LLC Hedge Fund•Long/Short	$3.3M 60.0K shares
P Philadelphia Financial Management of San Francisco, LLC Hedge Fund•Sector	$2.2M 39.5K shares
GABELLI SECURITIES INC Hedge Fund•Multi-Strategy	$2.1M 37.5K shares
Quantinno Capital Management LP Hedge Fund•Market Neutral	$1.6M 28.4K shares
Jain Global LLC Hedge Fund•Multi-Strategy	$1.3M 24.4K shares
AMI ASSET MANAGEMENT CORP Long Only Manager	$840.0K 15.3K shares
A ATRIA INVESTMENTS LLC Institution	$667.6K 12.1K shares

Exited Positions

Institution	Previous Position
ORBIMED ADVISORS LLC Hedge Fund•Sector	$35.6M 1.1M shares
CAPITAL FUND MANAGEMENT S.A. Hedge Fund•Quant Macro	$5.1M 154.4K shares
J Jump Financial, LLC Institution	$5.0M 151.3K shares
J JANE STREET GROUP, LLC Institution	$3.5M 106.1K shares
S SUPERSTRING CAPITAL MANAGEMENT LP Hedge Fund•Long/Short	$2.0M 61.1K shares
PANAGORA ASSET MANAGEMENT INC Hedge Fund•Quant	$1.5M 44.6K shares
Z Zweig-DiMenna Associates LLC Hedge Fund•Long/Short	$1.2M 35.6K shares
O ONTARIO TEACHERS PENSION PLAN BOARD Institution	$962.6K 29.1K shares
W Winton Capital Group Ltd Institution	$930.4K 28.2K shares
T Tejara Capital Ltd Institution	$604.6K 18.3K shares

Options Activity

Institutions with the largest Call and Put options positions in CYTK as of Q3 2025

Call Positions: 30
Call Value: $286.1M
Put Positions: 14
Put Value: $63.6M

Call Positions

Institution	Position Value
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$65.5M 11.9K contracts
ARMISTICE CAPITAL, LLC Hedge Fund•Long/Short	$52.2M 9.5K contracts
Integral Health Asset Management, LLC Hedge Fund•Sector	$41.2M 7.5K contracts
J JANE STREET GROUP, LLC Institution	$33.0M 6.0K contracts
BALYASNY ASSET MANAGEMENT LLC Hedge Fund•Multi-Strategy	$19.8M 3.6K contracts
Caption Management, LLC Hedge Fund•Long/Short	$16.2M 3.0K contracts
N NOMURA HOLDINGS INC Institution	$13.7M 2.5K contracts
BARCLAYS PLC Institution	$7.3M 1.3K contracts
Ikarian Capital, LLC Hedge Fund•Event Driven	$6.1M 1.1K contracts
W WOLVERINE TRADING, LLC Institution	$4.8M 898.0 contracts

Put Positions

Institution	Position Value
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$24.0M 4.4K contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$17.6M 3.2K contracts
J JANE STREET GROUP, LLC Institution	$6.0M 1.1K contracts
N NOMURA HOLDINGS INC Institution	$5.7M 1.0K contracts
Walleye Trading Advisors, LLC Hedge Fund•Multi-Strategy	$2.5M 453.0 contracts
Walleye Trading LLC RIA/Wealth	$1.7M 317.0 contracts
Point72 Asset Management, L.P. Hedge Fund•Multi-Strategy	$1.6M 300.0 contracts
CITIGROUP INC Institution	$1.4M 250.0 contracts
W WOLVERINE TRADING, LLC Institution	$1.1M 195.0 contracts
D D. E. Shaw & Co., Inc. Institution	$1.0M 184.0 contracts

Most Committed Institutions

Institutions with CYTK as the highest % of their portfolio as of Q3 2025

Institution	Key People	Portfolio Weight	Ownership	Owned Since	Total AUM (Long)
Sarissa Capital Management LP Hedge Fund•Activist	Alexander John Denner CEO	17.93% $32.3M	0.49% 588.4K shares	Q1 2024 Held for 1y 8m	$180.4M
Foresite Capital Management IV, LLC Venture Capital	James Bruce Tananbaum CEO	13.79% $25.2M	0.38% 458.3K shares	Q3 2025 Held for 2 months	$182.6M
R Rosalind Advisors, Inc. Institution	-	8.34% $22.0M	0.33% 400.0K shares	Q2 2025 Held for 5 months	$263.6M
Deep Track Capital, LP Hedge Fund•Long/Short	David Eric Kroin CIO	6.72% $236.3M	3.59% 4.3M shares	Q4 2023 Held for 1y 11m	$3.5B
Integral Health Asset Management, LLC Hedge Fund•Sector	Bhagwan Jay Rao CIO	5.82% $76.9M	1.17% 1.4M shares	Q1 2020 Held for 5y 8m	$1.3B
Melqart Asset Management Ltd Hedge Fund•Multi-Strategy	Michel Nmn Massoud CEO	5.62% $43.1M	0.66% 783.8K shares	Q1 2024 Held for 1y 8m	$766.2M
D DAFNA Capital Management LLC Hedge Fund•Event Driven	Nathan Fischel CEO	5.46% $21.7M	0.33% 394.9K shares	Q3 2021 Held for 4y 2m	$397.7M
Exome Asset Management LLC Hedge Fund•Sector	Alex R Forschner President	5.29% $7.8M	0.12% 142.4K shares	Q4 2023 Held for 1y 11m	$148.0M
N Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. Institution	-	5.06% $65.5M	1.00% 1.2M shares	Q4 2024 Held for 11 months	$1.3B
Catalio Capital Management, LP Venture Capital	Olga Eduardovna Maltseva COO	4.59% $24.8M	0.38% 451.6K shares	Q4 2024 Held for 11 months	$540.9M

Hedge Fund Spotlight

Discover hedge funds investing in CYTK

Weiss Asset Management LP

Hedge Fund • Multi-Strategy

Portfolio ManagerAndrew Murray Weiss

Portfolio Value: $5.2B
Positions: 533
Last Reported: Q3 2025

Sector Allocation

Position in Cytokinetics

Market Value: $3.5M
Shares Held: 64.2K
Portfolio Weight: 0.07%
Owned Since: 2025-Q3

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