Denali Therapeutics Inc.
DNLI • NASDAQ
Denali Therapeutics Inc. is a biotechnology company in the healthcare sector on NASDAQ, led by Alexander Schuth, M.D., with a market cap of $2.8B. As of Q3 2025, 92% of shares are held by 232 institutional investors, with BlackRock, Inc. as the largest holder at 8.41%.
Chief Operating and Financial OfficerAlexander Schuth, M.D.
Market Cap$2.8B
Biotechnology
Healthcare
Employees375.0
Websitedenalitherapeutics.com
Country
United States of America
Overview
Overview of institutional ownership in DNLI as of Q3 2025 with a market cap of $2.1B
All Institutions
- Institutions
- 232
- Value Held
- $2.0B
- Shares Held
- 134.8M
- Avg Position
- $8.4M
- Median Position
- $644.5K
Hedge Funds
- Hedge Funds
- 43
- Value Held
- $339.1M
- Shares Held
- 23.4M
- Avg Position
- $7.9M
- Median Position
- $1.6M
Ownership Breakdown
Based on market cap of $2.1B as of Q3 2025. Institutional (non-HF) excludes hedge funds to avoid double counting.
Biggest Investors
Institutions with the largest positions in DNLI as of Q3 2025
| Institution | Position Value |
|---|---|
B BlackRock, Inc. Institution | $178.4M 0.00% of portfolio |
 VANGUARD GROUP INC Institution | $174.1M 0.00% of portfolio |
B BAILLIE GIFFORD & CO Institution | $168.3M 0.12% of portfolio |
 FMR LLC Institution | $92.1M 0.00% of portfolio |
T T. Rowe Price Investment Management, Inc. Insurance Manager | $81.9M 0.05% of portfolio |
 UBS GLOBAL ASSET MANAGEMENT AMERICAS INC Long Only Manager | $79.4M 0.02% of portfolio |
 STATE STREET CORP Institution | $79.3M 0.00% of portfolio |
T TEMASEK HOLDINGS LTD Institution | $77.8M 0.27% of portfolio |
 Capital Research Global Investors RIA/Wealth | $69.1M 0.01% of portfolio |
 PRICE T ROWE ASSOCIATES INC /MD/ Long Only Manager | $66.3M 0.01% of portfolio |
Net Capital Flow
Institutional buying and selling activity for DNLI in Q3 2025
- Traded
- +$112.0M
- Buyers
- 123
- Sellers
- 85
- Total Bought
- +$239.7M
- Total Sold
- −$127.7M
- Avg Position
- $7.6M
Biggest Buyers
| Institution | Net Bought |
|---|---|
 Holocene Advisors, LP Hedge Fund•Long/Short | +$39.7M +2.7M shares |
T T. Rowe Price Investment Management, Inc. Insurance Manager | +$34.7M +2.4M shares |
 UBS Group AG Institution | +$15.4M +1.1M shares |
 StemPoint Capital LP Hedge Fund•Long/Short | +$14.9M +1.0M shares |
 Foresite Capital Management VI LLC Venture Capital | +$14.5M +1.0M shares |
STATE STREET CORP Institution | +$13.7M +946.3K shares |
 MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy | +$5.9M +406.7K shares |
 ALLIANCEBERNSTEIN L.P. Long Only Manager | +$5.6M +383.3K shares |
 MORGAN STANLEY RIA/Wealth | +$5.5M +377.5K shares |
 Trexquant Investment LP Hedge Fund•Quant | +$4.7M +321.3K shares |
Biggest Sellers
| Institution | Net Sold |
|---|---|
PRICE T ROWE ASSOCIATES INC /MD/ Long Only Manager | −$29.2M −2.0M shares |
FMR LLC Institution | −$17.4M −1.2M shares |
UBS GLOBAL ASSET MANAGEMENT AMERICAS INC Long Only Manager | −$11.6M −797.2K shares |
 Marshall Wace LLP Institution | −$9.0M −618.2K shares |
 CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy | −$8.1M −560.7K shares |
 Crestline Management, LP Hedge Fund•Multi-Strategy | −$6.5M −450.0K shares |
B BAILLIE GIFFORD & CO Institution | −$5.3M −363.7K shares |
N Nuveen, LLC Institution | −$4.5M −310.4K shares |
A AXA Institution | −$4.1M −293.9K shares |
 Edgestream Partners, L.P. Hedge Fund•Quant Macro | −$3.2M −219.1K shares |
Entry and Exit Activity
Institutions that initiated new positions or completely exited DNLI in Q3 2025
- New Positions
- 14
- New Value
- $19.9M
- Exited Positions
- 22
- Exited Value
- $14.1M
New Positions
| Institution | Position Value |
|---|---|
Foresite Capital Management VI LLC Venture Capital | $14.5M 1.0M shares |
L Lynx1 Capital Management LP Hedge Fund•Sector | $3.8M 261.7K shares |
C CANTOR FITZGERALD, L. P. Institution | $653.4K 45.0K shares |
 Quantinno Capital Management LP Hedge Fund•Market Neutral | $358.7K 24.7K shares |
E EntryPoint Capital, LLC Hedge Fund•Long/Short | $349.3K 24.1K shares |
I INTRUST BANK NA Institution | $153.5K 10.6K shares |
 Johnson Financial Group, Inc. RIA/Wealth | $28.7K 2.0K shares |
 Groupe la Francaise Fund of Funds | $7.7K 620.0 shares |
 Halbert, Hargrove/Russell LLC RIA/Wealth | $1.5K 104.0 shares |
 TD PRIVATE CLIENT WEALTH LLC RIA/Wealth | $1.0K 71.0 shares |
Exited Positions
| Institution | Previous Position |
|---|---|
A AXA Institution | $4.1M 293.9K shares |
T TWINBEECH CAPITAL LP Hedge Fund•Quant | $2.9M 210.4K shares |
 Soleus Capital Management, L.P. Hedge Fund•Long/Short | $2.5M 182.1K shares |
 Polar Securities Inc. Hedge Fund•Multi-Strategy | $1.3M 91.6K shares |
M Man Group plc Institution | $979.7K 70.0K shares |
S Skandinaviska Enskilda Banken AB Institution | $605.0K 43.2K shares |
 CAPITAL FUND MANAGEMENT S.A. Hedge Fund•Quant Macro | $306.0K 21.9K shares |
V Virtu Financial LLC Institution | $257.9K 18.4K shares |
 SPRINGBOK CAPITAL MANAGEMENT, LLC Fund of Funds | $223.0K 15.9K shares |
N NEOS Investment Management LLC Institution | $212.3K 15.2K shares |
Options Activity
Institutions with the largest Call and Put options positions in DNLI as of Q3 2025
- Call Positions
- 5
- Call Value
- $2.9M
- Put Positions
- 3
- Put Value
- $1.6M
Call Positions
| Institution | Position Value |
|---|---|
 Caption Management, LLC Hedge Fund•Long/Short | $1.3M 912.0 contracts |
 SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity | $1.1M 745.0 contracts |
J JANE STREET GROUP, LLC Institution | $354.3K 244.0 contracts |
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy | $168.4K 116.0 contracts |
 WELLS FARGO & COMPANY/MN Institution | - - contracts |
Put Positions
| Institution | Position Value |
|---|---|
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity | $1.1M 769.0 contracts |
Caption Management, LLC Hedge Fund•Long/Short | $435.6K 300.0 contracts |
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy | - - contracts |
Most Committed Institutions
Institutions with DNLI as the highest % of their portfolio as of Q3 2025
| Institution | Portfolio Weight |
|---|---|
Crestline Management, LP Hedge Fund•Multi-Strategy | 85.26% $49.5M |
Foresite Capital Management VI LLC Venture Capital | 5.61% $14.5M |
StemPoint Capital LP Hedge Fund•Long/Short | 5.08% $25.2M |
 YIHENG CAPITAL LLC Hedge Fund•Long/Short | 2.29% $6.8M |
M MASTERS CAPITAL MANAGEMENT LLC Hedge Fund•Long/Short | 2.09% $10.9M |
 Boxer Capital Management, LLC Hedge Fund•Long/Short | 1.20% $3.6M |
 Casdin Capital, LLC Hedge Fund•Sector | 1.12% $12.9M |
P Palo Alto Investors, LLC Hedge Fund•Long/Short | 1.10% $5.9M |
 PIER 88 INVESTMENT PARTNERS LLC Hedge Fund•Long/Short | 1.04% $979.2K |
L Lynx1 Capital Management LP Hedge Fund•Sector | 0.77% $3.8M |
Hedge Fund Spotlight
Discover hedge funds investing in DNLI
Schonfeld Strategic Advisors LLC
Hedge Fund • Multi-Strategy
Portfolio ManagerRyan Andrew Tolkin
- Portfolio Value
- $14.3B
- Positions
- 1,879
- Last Reported
- Q3 2025
Sector Allocation
Position in Denali Therapeutics Inc.
- Market Value
- $3.3M
- Shares Held
- 226.2K
- Portfolio Weight
- 0.02%
- Owned Since
- 2025-Q3
| Top Holding | Sector | Market Value | Weight |
|---|---|---|---|
ETF ETF | $1.3B | 9.09% | |
ETF ETF | $440.9M | 3.08% | |
Unknown Unknown | $337.6M | 2.36% |
