Iovance Biotherapeutics, Inc.

IOVA • NASDAQ

Iovance Biotherapeutics, Inc. is a biotechnology company in the healthcare sector on NASDAQ, led by Maria Fardis, with a market cap of $873.3M. As of Q3 2025, 59% of shares are held by 244 institutional investors, with MHR FUND MANAGEMENT LLC as the largest holder at 8.01%.

President and Chief Executive OfficerMaria Fardis

Market Cap$873.3M

Biotechnology

Healthcare

Employees557.0

Websiteiovance.com

Country

United States of America

Overview

Overview of institutional ownership in IOVA as of Q3 2025 with a market cap of $785.2M

All Institutions

Institutions: 244
Value Held: $461.9M
Shares Held: 212.9M
Avg Position: $1.9M
Median Position: $98.3K

Hedge Funds

Hedge Funds: 31
Value Held: $93.6M
Shares Held: 43.1M
Avg Position: $3.0M
Median Position: $247.2K

Ownership Breakdown

Institutional (non-HF)

46.91%

$368.4M

Hedge Funds

11.92%

$93.6M

Retail & Other

41.17%

$323.3M

Based on market cap of $785.2M as of Q3 2025. Institutional (non-HF) excludes hedge funds to avoid double counting.

Biggest Investors

Institutions with the largest positions in IOVA as of Q3 2025

Institution	Key People	Position Value	Ownership	Owned Since	Total AUM (Long)
M MHR FUND MANAGEMENT LLC Private Equity	Mark Howard Rachesky President	$62.9M 8.26% of portfolio	8.01% 29.0M shares	Q4 2022 Held for 2y 11m	$761.2M
B BlackRock, Inc. Institution	-	$56.3M 0.00% of portfolio	7.17% 26.0M shares	Q2 2015 Held for 10y 5m	$5.67T
VANGUARD GROUP INC Institution	Salim Ramji CEO	$52.2M 0.00% of portfolio	6.65% 24.1M shares	Q1 2015 Held for 10y 8m	$6.69T
STATE STREET CORP Institution	Ronald P. O'Hanley CEO	$28.9M 0.00% of portfolio	3.68% 13.3M shares	Q2 2015 Held for 10y 5m	$2.88T
I Invenomic Capital Management LP Hedge Fund•Long/Short	Benjamin Robert Deschaine President	$22.9M 1.19% of portfolio	2.91% 10.5M shares	Q1 2025 Held for 8 months	$1.9B
L Long Focus Capital Management, LLC Hedge Fund•Global Macro	John Byron Helmers CEO	$19.8M 1.16% of portfolio	2.52% 9.1M shares	Q4 2021 Held for 3y 11m	$1.7B
P Palo Alto Investors, LLC Hedge Fund•Long/Short	Angela Elizabeth Nguyen-Dinh CCO	$16.5M 3.06% of portfolio	2.11% 7.6M shares	Q4 2023 Held for 1y 11m	$540.4M
GEODE CAPITAL MANAGEMENT LLC ETF Provider	David Kenneth Lane CEO	$14.9M 0.00% of portfolio	1.90% 6.9M shares	Q2 2015 Held for 10y 5m	$1.57T
GOLDMAN SACHS GROUP INC Institution	David M. Solomon CEO	$14.3M 0.00% of portfolio	1.82% 6.6M shares	Q1 2015 Held for 10y 8m	$691.34B
BANK OF AMERICA CORP /DE/ Institution	Brian T. Moynihan CEO	$13.6M 0.00% of portfolio	1.74% 6.3M shares	Q2 2015 Held for 10y 5m	$1.33T

Net Capital Flow

Institutional buying and selling activity for IOVA in Q3 2025

Traded: −$6.5M
Buyers: 124
Sellers: 106
Total Bought: +$56.8M
Total Sold: −$63.3M
Avg Position: $1.6M

Biggest Buyers

Institution	Net Bought	Current Position
P Palo Alto Investors, LLC Hedge Fund•Long/Short	+$9.1M +4.2M shares	$16.5M 7.6M shares
STATE STREET CORP Institution	+$7.4M +3.4M shares	$28.9M 13.3M shares
B BlackRock, Inc. Institution	+$5.9M +2.7M shares	$56.3M 26.0M shares
BANK OF AMERICA CORP /DE/ Institution	+$4.9M +2.2M shares	$13.6M 6.3M shares
I Invenomic Capital Management LP Hedge Fund•Long/Short	+$4.9M +2.2M shares	$22.9M 10.5M shares
GOLDMAN SACHS GROUP INC Institution	+$4.0M +1.8M shares	$14.3M 6.6M shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	+$2.7M +1.2M shares	$7.2M 3.3M shares
Susquehanna Portfolio Strategies, LLC Private Equity	+$2.0M +912.1K shares	$2.0M 912.1K shares
GEODE CAPITAL MANAGEMENT LLC ETF Provider	+$1.5M +679.2K shares	$14.9M 6.9M shares
SCHWAB CHARLES INVESTMENT MANAGEMENT INC Long Only Manager	+$1.3M +588.1K shares	$5.4M 2.5M shares

Biggest Sellers

Institution	Net Sold	Current Position
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	−$10.7M −4.9M shares	$9.6M 4.4M shares
RENAISSANCE TECHNOLOGIES LLC Hedge Fund•Quant	−$8.4M −4.9M shares	Sold Off 0 shares
L Long Focus Capital Management, LLC Hedge Fund•Global Macro	−$5.9M −2.7M shares	$19.8M 9.1M shares
Soleus Capital Management, L.P. Hedge Fund•Long/Short	−$5.0M −2.3M shares	$2.1M 976.7K shares
TWO SIGMA INVESTMENTS LLC Hedge Fund•Multi-Strategy	−$4.1M −1.9M shares	$5.9M 2.7M shares
PRINCIPAL FINANCIAL GROUP INC Institution	−$3.4M −1.6M shares	$6.5M 3.0M shares
TWO SIGMA ADVISERS, LLC Hedge Fund•Multi-Strategy	−$2.8M −1.3M shares	$2.3M 1.1M shares
T TANG CAPITAL MANAGEMENT LLC Institution	−$2.7M −1.3M shares	$1.2M 543.8K shares
VANGUARD GROUP INC Institution	−$2.2M −1.0M shares	$52.2M 24.1M shares
MORGAN STANLEY RIA/Wealth	−$1.9M −869.4K shares	$12.1M 5.6M shares

Entry and Exit Activity

Institutions that initiated new positions or completely exited IOVA in Q3 2025

New Positions: 13
New Value: $3.0M
Exited Positions: 38
Exited Value: $12.1M

New Positions

Institution	Position Value
Susquehanna Portfolio Strategies, LLC Private Equity	$2.0M 912.1K shares
N NEOS Investment Management LLC Institution	$377.3K 173.9K shares
T TEMA ETFS LLC Institution	$377.3K 173.9K shares
C Centurion Wealth Management LLC Institution	$115.2K 53.1K shares
Sheets Smith Investment Management RIA/Wealth	$44.2K 20.4K shares
Wealthfront Advisers LLC RIA/Wealth	$33.6K 15.5K shares
G Ground Swell Capital, LLC Hedge Fund•Multi-Strategy	$24.0K 11.0K shares
B BNP Paribas Investment Partners S.A. Institution	$4.8K 2.2K shares
SRS Capital Advisors, Inc. RIA/Wealth	$2.8K 1.3K shares
Hurley Capital, LLC RIA/Wealth	$2.2K 1.0K shares

Exited Positions

Institution	Previous Position
RENAISSANCE TECHNOLOGIES LLC Hedge Fund•Quant	$8.4M 4.9M shares
SCHRODER INVESTMENT MANAGEMENT GROUP RIA/Wealth	$1.5M 897.4K shares
Polar Securities Inc. Hedge Fund•Multi-Strategy	$746.3K 433.9K shares
Q Quadrature Capital Ltd Institution	$247.2K 144.1K shares
Marshall Wace LLP Institution	$191.3K 111.2K shares
Jain Global LLC Hedge Fund•Multi-Strategy	$141.2K 82.1K shares
B BANQUE PICTET & CIE SA Institution	$106.8K 62.1K shares
A AXQ CAPITAL, LP Hedge Fund•Market Neutral	$97.0K 56.4K shares
AE Wealth Management LLC RIA/Wealth	$91.1K 52.9K shares
CALIBER WEALTH MANAGEMENT, LLC / KS RIA/Wealth	$86.8K 50.5K shares

Options Activity

Institutions with the largest Call and Put options positions in IOVA as of Q3 2025

Call Positions: 10
Call Value: $5.2M
Put Positions: 4
Put Value: $3.6M

Call Positions

Institution	Position Value
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$3.1M 14.4K contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$1.3M 5.8K contracts
W WOLVERINE TRADING, LLC Institution	$470.1K 2.1K contracts
J JANE STREET GROUP, LLC Institution	$222.0K 1.0K contracts
A ADAR1 Capital Management, LLC Hedge Fund•Long/Short	$108.5K 500.0 contracts
SHELTON WEALTH MANAGEMENT, LLC RIA/Wealth	$28.2K 130.0 contracts
Walleye Trading Advisors, LLC Hedge Fund•Multi-Strategy	$8.0K 37.0 contracts
R Raiffeisen Bank International AG Institution	$4.3K 20.0 contracts
H HB Wealth Management, LLC Institution	$4.3K 20.0 contracts
L LPL Financial LLC Institution	- - contracts

Put Positions

Institution	Position Value
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$2.0M 9.2K contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$1.4M 6.5K contracts
J JANE STREET GROUP, LLC Institution	$148.6K 685.0 contracts
W WOLVERINE TRADING, LLC Institution	$94.3K 423.0 contracts

Most Committed Institutions

Institutions with IOVA as the highest % of their portfolio as of Q3 2025

Institution	Key People	Portfolio Weight	Ownership	Owned Since	Total AUM (Long)
M MHR FUND MANAGEMENT LLC Private Equity	Mark Howard Rachesky President	8.26% $62.9M	8.01% 29.0M shares	Q4 2022 Held for 2y 11m	$761.2M
B B Group, Inc. Institution	-	3.76% $3.3M	0.41% 1.5M shares	Q4 2024 Held for 11 months	$86.6M
P Palo Alto Investors, LLC Hedge Fund•Long/Short	Angela Elizabeth Nguyen-Dinh CCO	3.06% $16.5M	2.11% 7.6M shares	Q4 2023 Held for 1y 11m	$540.4M
O Orion Investment Co RIA/Wealth	Frederic George Sauer President	1.28% $4.0M	0.51% 1.9M shares	Q2 2024 Held for 1y 5m	$314.7M
C CM Management, LLC Institution	-	1.27% $1.5M	0.19% 700.0K shares	Q3 2023 Held for 2y 2m	$119.9M
I Invenomic Capital Management LP Hedge Fund•Long/Short	Benjamin Robert Deschaine President	1.19% $22.9M	2.91% 10.5M shares	Q1 2025 Held for 8 months	$1.9B
L Long Focus Capital Management, LLC Hedge Fund•Global Macro	John Byron Helmers CEO	1.16% $19.8M	2.52% 9.1M shares	Q4 2021 Held for 3y 11m	$1.7B
P Parametrica Management Ltd Institution	-	0.66% $425.1K	0.05% 195.9K shares	Q2 2021 Held for 4y 5m	$64.6M
Kennondale Capital Management LLC RIA/Wealth	Andrew Slay Managing Partner	0.53% $690.5K	0.09% 318.2K shares	Q4 2024 Held for 11 months	$130.6M
Rhenman & Partners Asset Management AB RIA/Wealth	William Eddy Roark Managing Partner	0.26% $2.4M	0.30% 1.1M shares	Q2 2015 Held for 10y 5m	$903.7M

Hedge Fund Spotlight

Discover hedge funds investing in IOVA

QVT Financial LP

Hedge Fund • Multi-Strategy

Portfolio ManagerDaniel Allen Gold

Portfolio Value: $873.7M
Positions: 42
Last Reported: Q3 2025

Sector Allocation

Position in Iovance Biotherapeutics, Inc.

Market Value: $1.5M
Shares Held: 678.6K
Portfolio Weight: 0.17%
Owned Since: 2015-Q1

Top Holding	Sector	Market Value	Weight
1 Roivant Sciences ROIV	Biotechnology Healthcare	$444.5M	50.88%
2 Tourmaline Bio TRML	Biotechnology Healthcare	$103.1M	11.80%
3 Allot Ltd. ALLT	Software - Infrastructure Technology	$47.7M	5.46%