Karyopharm Therapeutics

KPTI • NASDAQ

Karyopharm Therapeutics is a biotechnology company in the healthcare sector on NASDAQ, led by Richard Paulson, with a market cap of $118.5M. As of Q3 2025, 34% of shares are held by 52 institutional investors, with T. Rowe Price Investment Management, Inc. as the largest holder at 8.08%.

President and Chief Executive OfficerRichard Paulson

Market Cap$118.5M

Biotechnology

Healthcare

Employees325.0

Websitekaryopharm.com

Country

United States of America

Overview

Overview of institutional ownership in KPTI as of Q3 2025 with a market cap of $56.7M

All Institutions

Institutions: 52
Value Held: $19.5M
Shares Held: 3.0M
Avg Position: $374.3K
Median Position: $82.3K

Hedge Funds

Hedge Funds: 8
Value Held: $2.2M
Shares Held: 333.8K
Avg Position: $272.9K
Median Position: $180.6K

Ownership Breakdown

Institutional (non-HF)

30.47%

$17.3M

Hedge Funds

3.85%

$2.2M

Retail & Other

65.68%

$37.2M

Based on market cap of $56.7M as of Q3 2025. Institutional (non-HF) excludes hedge funds to avoid double counting.

Biggest Investors

Institutions with the largest positions in KPTI as of Q3 2025

Institution	Key People	Position Value	Ownership	Owned Since	Total AUM (Long)
T T. Rowe Price Investment Management, Inc. Insurance Manager	John Edward Robison President	$4.6M 0.00% of portfolio	8.08% 701.0K shares	Q1 2025 Held for 8 months	$161.58B
A ADAGE CAPITAL PARTNERS GP LLC Institution	-	$2.8M 0.00% of portfolio	4.86% 421.3K shares	Q4 2023 Held for 1y 11m	$63.0B
VANGUARD GROUP INC Institution	Salim Ramji CEO	$2.7M 0.00% of portfolio	4.71% 408.2K shares	Q4 2013 Held for 11y 11m	$6.69T
B BlackRock, Inc. Institution	-	$1.5M 0.00% of portfolio	2.67% 232.0K shares	Q4 2013 Held for 11y 11m	$5.67T
Catalio Capital Management, LP Venture Capital	Olga Eduardovna Maltseva COO	$935.1K 0.17% of portfolio	1.65% 143.0K shares	Q4 2024 Held for 11 months	$540.9M
A Avidity Partners Management LP Hedge Fund•Long/Short	Michael David Gregory President	$880.1K 0.21% of portfolio	1.55% 134.6K shares	Q4 2022 Held for 2y 11m	$429.1M
Marshall Wace LLP Institution	Diana Lj Harrison President	$840.1K 0.00% of portfolio	1.48% 128.5K shares	Q4 2021 Held for 3y 11m	$90.3B
C CAM Group Holding A/S Institution	-	$654.0K 0.01% of portfolio	1.15% 100.0K shares	Q4 2020 Held for 4y 11m	$5.7B
GEODE CAPITAL MANAGEMENT LLC ETF Provider	David Kenneth Lane CEO	$610.3K 0.00% of portfolio	1.08% 93.3K shares	Q4 2013 Held for 11y 11m	$1.57T
G GROUP ONE TRADING, L.P. Institution	-	$447.6K 0.01% of portfolio	0.79% 68.4K shares	Q2 2025 Held for 5 months	$3.3B

Net Capital Flow

Institutional buying and selling activity for KPTI in Q3 2025

Traded: −$4.9M
Buyers: 18
Sellers: 21
Total Bought: +$711.9K
Total Sold: −$5.6M
Avg Position: $341.4K

Biggest Buyers

Institution	Net Bought	Current Position
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	+$231.1K +35.3K shares	$231.1K 35.3K shares
A ADAR1 Capital Management, LLC Hedge Fund•Long/Short	+$163.5K +25.0K shares	$163.5K 25.0K shares
Baird Financial Group, Inc. Private Equity	+$100.7K +15.4K shares	$169.6K 25.9K shares
B Belvedere Trading LLC Institution	+$95.2K +14.6K shares	$95.2K 14.6K shares
STATE STREET CORP Institution	+$85.3K +13.0K shares	$303.1K 46.3K shares
GEODE CAPITAL MANAGEMENT LLC ETF Provider	+$9.5K +1.4K shares	$610.3K 93.3K shares
X XTX Topco Ltd Institution	+$8.8K +1.3K shares	$94.2K 14.4K shares
MORGAN STANLEY RIA/Wealth	+$4.4K +675.0 shares	$168.5K 25.8K shares
JPMORGAN CHASE & CO Institution	+$3.6K +-255.9K shares	$3.6K 550.0 shares
CITIGROUP INC Institution	+$3.4K +-6.5K shares	$3.4K 513.0 shares

Biggest Sellers

Institution	Net Sold	Current Position
Eversept Partners, LLC Hedge Fund•Long/Short	−$1.1M −257.2K shares	Sold Off 0 shares
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	−$891.2K −206.8K shares	Sold Off 0 shares
P Palo Alto Investors, LLC Hedge Fund•Long/Short	−$809.9K −187.9K shares	Sold Off 0 shares
VANGUARD GROUP INC Institution	−$719.7K −110.0K shares	$2.7M 408.2K shares
UBS Group AG Institution	−$668.5K −102.2K shares	$390.3K 59.7K shares
GOLDMAN SACHS GROUP INC Institution	−$552.8K −84.5K shares	$162.7K 24.9K shares
SILVERBACK ASSET MANAGEMENT LLC Hedge Fund•Multi-Strategy	−$196.2K −30.0K shares	$261.6K 40.0K shares
G GROUP ONE TRADING, L.P. Institution	−$192.7K −29.5K shares	$447.6K 68.4K shares
T T. Rowe Price Investment Management, Inc. Insurance Manager	−$181.6K −27.8K shares	$4.6M 701.0K shares
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	−$137.3K −31.8K shares	Sold Off 0 shares

Entry and Exit Activity

Institutions that initiated new positions or completely exited KPTI in Q3 2025

New Positions: 2
New Value: $877.0
Exited Positions: 5
Exited Value: $2.9M

New Positions

Institution	Position Value
Rise Advisors, LLC RIA/Wealth	$857.0 131.0 shares
PITTENGER & ANDERSON INC RIA/Wealth	$20.0 3.0 shares

Exited Positions

Institution	Previous Position
Eversept Partners, LLC Hedge Fund•Long/Short	$1.1M 257.2K shares
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$891.2K 206.8K shares
P Palo Alto Investors, LLC Hedge Fund•Long/Short	$809.9K 187.9K shares
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	$137.3K 31.8K shares
RAYMOND JAMES FINANCIAL INC RIA/Wealth	$388.0 90.0 shares

Options Activity

Institutions with the largest Call and Put options positions in KPTI as of Q3 2025

Call Positions: 4
Call Value: $2.2M
Put Positions: 3
Put Value: $1.1M

Call Positions

Institution	Position Value
Affinity Asset Advisors, LLC Hedge Fund•Long/Short	$1.0M 1.6K contracts
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$777.6K 1.2K contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$302.8K 463.0 contracts
J JANE STREET GROUP, LLC Institution	$84.4K 129.0 contracts

Put Positions

Institution	Position Value
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$835.8K 1.3K contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$298.9K 457.0 contracts
B Belvedere Trading LLC Institution	$3.3K 5.0 contracts

Most Committed Institutions

Institutions with KPTI as the highest % of their portfolio as of Q3 2025

Institution	Key People	Portfolio Weight	Ownership	Owned Since	Total AUM (Long)
SILVERBACK ASSET MANAGEMENT LLC Hedge Fund•Multi-Strategy	Elliot Glen Bossen CEO	0.97% $261.6K	0.46% 40.0K shares	Q1 2025 Held for 8 months	$27.0M
A Avidity Partners Management LP Hedge Fund•Long/Short	Michael David Gregory President	0.21% $880.1K	1.55% 134.6K shares	Q4 2022 Held for 2y 11m	$429.1M
Catalio Capital Management, LP Venture Capital	Olga Eduardovna Maltseva COO	0.17% $935.1K	1.65% 143.0K shares	Q4 2024 Held for 11 months	$540.9M
B Birchview Capital, LP Hedge Fund•Value	Matthew William Strobeck CIO	0.14% $183.0K	0.32% 28.0K shares	Q2 2018 Held for 7y 5m	$130.3M
Ikarian Capital, LLC Hedge Fund•Event Driven	Neil Tristan Shahrestani CEO	0.04% $178.3K	0.31% 27.3K shares	Q1 2023 Held for 2y 8m	$494.3M
A ADAR1 Capital Management, LLC Hedge Fund•Long/Short	Daniel Pawel Schneeberger Managing Partner	0.02% $163.5K	0.29% 25.0K shares	Q3 2025 Held for 2 months	$993.7M
G GROUP ONE TRADING, L.P. Institution	-	0.01% $447.6K	0.79% 68.4K shares	Q2 2025 Held for 5 months	$3.3B
C CAM Group Holding A/S Institution	-	0.01% $654.0K	1.15% 100.0K shares	Q4 2020 Held for 4y 11m	$5.7B
GSA CAPITAL PARTNERS LLP Hedge Fund•Quant	David Khabie-Zeitoune CEO	0.01% $92.1K	0.16% 14.1K shares	Q3 2023 Held for 2y 2m	$1.1B
B Belvedere Trading LLC Institution	-	0.01% $95.2K	0.17% 14.6K shares	Q3 2025 Held for 2 months	$1.2B

Hedge Fund Spotlight

Discover hedge funds investing in KPTI

SILVERBACK ASSET MANAGEMENT LLC

Hedge Fund • Multi-Strategy

Portfolio ManagerElliot Glen Bossen

Portfolio Value: $27.0M
Positions: 9
Last Reported: Q3 2025

Sector Allocation

Position in Karyopharm Therapeutics

Market Value: $261.6K
Shares Held: 40.0K
Portfolio Weight: 0.97%
Owned Since: 2025-Q1

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3 Accuray ARAY	Medical - Specialties Healthcare	$1.8M	6.58%