PTC Therapeutics

PTCT • NASDAQ

PTC Therapeutics is a biotechnology company in the healthcare sector on NASDAQ, led by Dr. Matthew B. Klein, with a market cap of $6.1B. As of Q3 2025, 104% of shares are held by 287 institutional investors, with VANGUARD GROUP INC as the largest holder at 10.43%.

Chief Executive OfficerDr. Matthew B. Klein

Market Cap$6.1B

Biotechnology

Healthcare

Employees995.0

Websiteptcbio.com

Country

United States of America

Overview

Overview of institutional ownership in PTCT as of Q3 2025 with a market cap of $4.9B

All Institutions

Institutions: 287
Value Held: $5.1B
Shares Held: 82.7M
Avg Position: $17.7M
Median Position: $1.1M

Hedge Funds

Hedge Funds: 40
Value Held: $1.3B
Shares Held: 20.5M
Avg Position: $31.5M
Median Position: $3.4M

Ownership Breakdown

Institutional (non-HF)

78.23%

$3.8B

Hedge Funds

25.83%

$1.3B

Retail & Other

Based on market cap of $4.9B as of Q3 2025. Institutional (non-HF) excludes hedge funds to avoid double counting.

Biggest Investors

Institutions with the largest positions in PTCT as of Q3 2025

Institution	Key People	Position Value	Ownership	Owned Since	Total AUM (Long)
VANGUARD GROUP INC Institution	Salim Ramji CEO	$508.7M 0.01% of portfolio	10.43% 8.3M shares	Q3 2013 Held for 12y 2m	$6.69T
RTW INVESTMENTS, LLC Hedge Fund•Sector	Peter M Fong President	$475.4M 5.90% of portfolio	9.75% 7.7M shares	Q4 2016 Held for 8y 11m	$8.1B
B BlackRock, Inc. Institution	-	$437.6M 0.01% of portfolio	8.98% 7.1M shares	Q3 2013 Held for 12y 2m	$5.67T
WELLINGTON MANAGEMENT CO LLP Long Only Manager	Jean Marie Hynes CEO	$301.9M 0.05% of portfolio	6.19% 4.9M shares	Q3 2013 Held for 12y 2m	$571.21B
HENDERSON GROUP PLC Institution	Ali Dibadj CEO	$231.7M 0.11% of portfolio	4.75% 3.8M shares	Q1 2019 Held for 6y 8m	$218.74B
ARMISTICE CAPITAL, LLC Hedge Fund•Long/Short	Steven Joseph Boyd Managing Partner	$201.1M 6.38% of portfolio	4.13% 3.3M shares	Q4 2018 Held for 6y 11m	$3.2B
TORONTO DOMINION BANK Institution	Leo Salom CEO	$199.2M 0.39% of portfolio	4.09% 3.2M shares	Q4 2024 Held for 11 months	$51.2B
STATE STREET CORP Institution	Ronald P. O'Hanley CEO	$192.4M 0.01% of portfolio	3.95% 3.1M shares	Q3 2013 Held for 12y 2m	$2.88T
D D. E. Shaw & Co., Inc. Institution	-	$133.5M 0.12% of portfolio	2.74% 2.2M shares	Q3 2015 Held for 10y 2m	$115.81B
GEODE CAPITAL MANAGEMENT LLC ETF Provider	David Kenneth Lane CEO	$119.7M 0.01% of portfolio	2.46% 2.0M shares	Q3 2013 Held for 12y 2m	$1.57T

Net Capital Flow

Institutional buying and selling activity for PTCT in Q3 2025

Traded: +$206.2M
Buyers: 156
Sellers: 137
Total Bought: +$743.9M
Total Sold: −$537.8M
Avg Position: $15.5M

Biggest Buyers

Institution	Net Bought	Current Position
LEUCADIA NATIONAL CORP Institution	+$97.3M +1.6M shares	$97.3M 1.6M shares
Point72 Asset Management, L.P. Hedge Fund•Multi-Strategy	+$74.9M +1.2M shares	$74.9M 1.2M shares
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	+$49.7M +810.5K shares	$106.2M 1.7M shares
TORONTO DOMINION BANK Institution	+$49.1M +800.6K shares	$199.2M 3.2M shares
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	+$41.2M +672.1K shares	$64.8M 1.1M shares
HENDERSON GROUP PLC Institution	+$36.7M +598.5K shares	$231.7M 3.8M shares
P Palo Alto Investors, LLC Hedge Fund•Long/Short	+$28.0M +456.1K shares	$52.9M 862.6K shares
T TANG CAPITAL MANAGEMENT LLC Institution	+$24.5M +400.0K shares	$92.1M 1.5M shares
M MANUFACTURERES LIFE INSURANCE CO Institution	+$23.5M +383.3K shares	$26.1M 425.0K shares
Pictet Asset Management Holding SA Long Only Manager	+$22.4M +366.5K shares	$86.2M 1.4M shares

Biggest Sellers

Institution	Net Sold	Current Position
ARMISTICE CAPITAL, LLC Hedge Fund•Long/Short	−$89.5M −1.5M shares	$201.1M 3.3M shares
MORGAN STANLEY RIA/Wealth	−$45.7M −743.9K shares	$25.7M 419.4K shares
VANGUARD GROUP INC Institution	−$34.3M −558.5K shares	$508.7M 8.3M shares
A Assenagon Asset Management S.A. Institution	−$32.2M −524.0K shares	$6.6M 107.6K shares
M Man Group plc Institution	−$24.9M −406.3K shares	$16.3M 265.2K shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	−$24.1M −392.4K shares	$2.4M 39.4K shares
Marshall Wace LLP Institution	−$23.3M −380.0K shares	$9.7M 157.7K shares
B BlackRock, Inc. Institution	−$21.5M −349.6K shares	$437.6M 7.1M shares
A ADAGE CAPITAL PARTNERS GP LLC Institution	−$19.3M −314.9K shares	$17.9M 291.0K shares
D D. E. Shaw & Co., Inc. Institution	−$16.1M −263.1K shares	$133.5M 2.2M shares

Entry and Exit Activity

Institutions that initiated new positions or completely exited PTCT in Q3 2025

New Positions: 32
New Value: $63.7M
Exited Positions: 40
Exited Value: $52.3M

New Positions

Institution	Position Value
Robeco Investment Management, Inc. Long Only Manager	$22.2M 361.7K shares
Boxer Capital Management, LLC Hedge Fund•Long/Short	$12.3M 200.0K shares
WCM INVESTMENT MANAGEMENT/CA Long Only Manager	$8.9M 147.1K shares
Cinctive Capital Management LP Hedge Fund•Multi-Strategy	$5.8M 95.3K shares
Point72 Europe LLP Digital Asset Manager	$3.8M 62.4K shares
QRG CAPITAL MANAGEMENT, INC. Long Only Manager	$2.1M 34.1K shares
Empirical Financial Services, LLC RIA/Wealth	$1.3M 20.8K shares
B Brummer Multi-Strategy AB Institution	$1.2M 19.1K shares
P Private Capital Advisors, Inc. RIA/Wealth	$985.7K 16.1K shares
B B. Metzler seel. Sohn & Co. AG Institution	$944.0K 15.4K shares

Exited Positions

Institution	Previous Position
Trexquant Investment LP Hedge Fund•Quant	$13.3M 272.8K shares
C CANADA PENSION PLAN INVESTMENT BOARD Institution	$10.3M 211.0K shares
S Squarepoint Ops LLC Hedge Fund•Quant	$8.9M 182.0K shares
J Jump Financial, LLC Institution	$2.5M 51.6K shares
JUPITER ASSET MANAGEMENT LTD Long Only Manager	$2.3M 46.1K shares
C Cubist Systematic Strategies, LLC Institution	$2.2M 45.6K shares
Graham Capital Management, L.P. Hedge Fund•Multi-Strategy	$1.3M 26.1K shares
PDT Partners, LLC Hedge Fund•Quant	$1.3M 25.7K shares
SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC Hedge Fund•Distressed	$1.1M 21.9K shares
Bayforest Capital Ltd Hedge Fund•Quant	$917.2K 18.8K shares

Options Activity

Institutions with the largest Call and Put options positions in PTCT as of Q3 2025

Call Positions: 11
Call Value: $49.8M
Put Positions: 8
Put Value: $12.7M

Call Positions

Institution	Position Value
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$13.5M 2.2K contracts
Ikarian Capital, LLC Hedge Fund•Event Driven	$13.1M 2.1K contracts
J JANE STREET GROUP, LLC Institution	$12.4M 2.0K contracts
BOOTHBAY FUND MANAGEMENT, LLC Fund of Funds	$5.1M 832.0 contracts
Caption Management, LLC Hedge Fund•Long/Short	$3.7M 600.0 contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$1.5M 240.0 contracts
W WOLVERINE TRADING, LLC Institution	$388.2K 64.0 contracts
Walleye Trading LLC RIA/Wealth	$135.0K 22.0 contracts
Steel Peak Wealth Management LLC RIA/Wealth	$61.4K - contracts
CITIGROUP INC Institution	- - contracts

Put Positions

Institution	Position Value
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$7.6M 1.2K contracts
Caption Management, LLC Hedge Fund•Long/Short	$3.7M 600.0 contracts
J JANE STREET GROUP, LLC Institution	$564.6K 92.0 contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$521.6K 85.0 contracts
Walleye Trading LLC RIA/Wealth	$196.4K 32.0 contracts
Walleye Trading Advisors, LLC Hedge Fund•Multi-Strategy	$116.6K 19.0 contracts
CITIGROUP INC Institution	- - contracts
W WOLVERINE TRADING, LLC Institution	- - contracts

Most Committed Institutions

Institutions with PTCT as the highest % of their portfolio as of Q3 2025

Institution	Key People	Portfolio Weight	Ownership	Owned Since	Total AUM (Long)
B Brummer Multi-Strategy AB Institution	-	21.40% $1.2M	0.02% 19.1K shares	Q3 2025 Held for 2 months	$5.5M
P Palo Alto Investors, LLC Hedge Fund•Long/Short	Angela Elizabeth Nguyen-Dinh CCO	9.80% $52.9M	1.09% 862.6K shares	Q3 2024 Held for 1y 2m	$540.4M
ARMISTICE CAPITAL, LLC Hedge Fund•Long/Short	Steven Joseph Boyd Managing Partner	6.38% $201.1M	4.13% 3.3M shares	Q4 2018 Held for 6y 11m	$3.2B
RTW INVESTMENTS, LLC Hedge Fund•Sector	Peter M Fong President	5.90% $475.4M	9.75% 7.7M shares	Q4 2016 Held for 8y 11m	$8.1B
MPM Oncology Impact Management LP Institution	Christian Albrecht Wulf Von Schimmelmann Managing Partner	4.41% $26.9M	0.55% 438.5K shares	Q3 2024 Held for 1y 2m	$610.9M
Boxer Capital Management, LLC Hedge Fund•Long/Short	Aaron Isaac Davis CEO	4.04% $12.3M	0.25% 200.0K shares	Q3 2025 Held for 2 months	$303.5M
T TANG CAPITAL MANAGEMENT LLC Institution	-	3.62% $92.1M	1.89% 1.5M shares	Q4 2023 Held for 1y 11m	$2.5B
Ikarian Capital, LLC Hedge Fund•Event Driven	Neil Tristan Shahrestani CEO	3.48% $17.2M	0.35% 280.6K shares	Q3 2025 Held for 2 months	$494.3M
S SECTOR GAMMA AS Institution	-	1.80% $7.2M	0.15% 118.1K shares	Q4 2024 Held for 11 months	$403.3M
Parkman Healthcare Partners LLC Hedge Fund•Long/Short	Gregory Arthur Martinez CIO	1.36% $12.4M	0.25% 202.4K shares	Q3 2024 Held for 1y 2m	$910.1M

Hedge Fund Spotlight

Discover hedge funds investing in PTCT

Point72 Asset Management, L.P.

Hedge Fund • Multi-Strategy

Portfolio ManagerSteven Alan Cohen

Portfolio Value: $43.2B
Positions: 1,279
Last Reported: Q3 2025

Sector Allocation

Position in PTC Therapeutics

Market Value: $74.9M
Shares Held: 1.2M
Portfolio Weight: 0.17%
Owned Since: 2023-Q4

Top Holding	Sector	Market Value	Weight
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3 Arista Networks ANET	Computer Hardware Technology	$803.1M	1.86%