Summit Therapeutics

SMMT • NASDAQ

Summit Therapeutics is a biotechnology company in the healthcare sector on NASDAQ, led by Robert Duggan, with a market cap of $13.1B. As of Q3 2025, 14% of shares are held by 230 institutional investors, with BAKER BROS. ADVISORS LP as the largest holder at 4.54%.

Chief Executive Officer and Chairman of the BoardRobert Duggan

Market Cap$13.1B

Biotechnology

Healthcare

Employees105.0

Websitesmmttx.com

Country

United States of America

Overview

Overview of institutional ownership in SMMT as of Q3 2025 with a market cap of $15.3B

All Institutions

Institutions: 230
Value Held: $2.1B
Shares Held: 102.9M
Avg Position: $9.2M
Median Position: $395.4K

Hedge Funds

Hedge Funds: 27
Value Held: $787.3M
Shares Held: 38.1M
Avg Position: $29.2M
Median Position: $2.3M

Ownership Breakdown

Institutional (non-HF)

8.71%

$1.3B

Hedge Funds

5.13%

$787.3M

Retail & Other

86.16%

$13.2B

Based on market cap of $15.3B as of Q3 2025. Institutional (non-HF) excludes hedge funds to avoid double counting.

Biggest Investors

Institutions with the largest positions in SMMT as of Q3 2025

Institution	Key People	Position Value	Ownership	Owned Since	Total AUM (Long)
B BAKER BROS. ADVISORS LP Hedge Fund•Sector	Scott Lawrence Lessing President	$696.7M 6.45% of portfolio	4.54% 33.7M shares	Q2 2024 Held for 1y 5m	$10.8B
VANGUARD GROUP INC Institution	Salim Ramji CEO	$235.1M 0.00% of portfolio	1.53% 11.4M shares	Q4 2020 Held for 4y 11m	$6.69T
FMR LLC Institution	-	$184.2M 0.01% of portfolio	1.20% 8.9M shares	Q2 2023 Held for 2y 5m	$1.92T
B BlackRock, Inc. Institution	-	$152.1M 0.00% of portfolio	0.99% 7.4M shares	Q4 2020 Held for 4y 11m	$5.67T
STATE STREET CORP Institution	Ronald P. O'Hanley CEO	$131.4M 0.00% of portfolio	0.86% 6.4M shares	Q4 2022 Held for 2y 11m	$2.88T
PRICE T ROWE ASSOCIATES INC /MD/ Long Only Manager	Robert W Sharps President	$93.8M 0.01% of portfolio	0.61% 4.5M shares	Q2 2023 Held for 2y 5m	$912.31B
GEODE CAPITAL MANAGEMENT LLC ETF Provider	David Kenneth Lane CEO	$64.7M 0.00% of portfolio	0.42% 3.1M shares	Q2 2020 Held for 5y 5m	$1.57T
MORGAN STANLEY RIA/Wealth	Jed Finn CEO	$39.8M 0.00% of portfolio	0.26% 1.9M shares	Q4 2017 Held for 7y 11m	$1.65T
Pictet Asset Management Holding SA Long Only Manager	Elizabeth Retta Dillon CEO	$33.5M 0.03% of portfolio	0.22% 1.6M shares	Q1 2024 Held for 1y 8m	$103.68B
APEIRON CAPITAL Ltd RIA/Wealth	James Michael Marsden Owner	$27.1M 12.87% of portfolio	0.18% 1.3M shares	Q2 2025 Held for 5 months	$210.4M

Net Capital Flow

Institutional buying and selling activity for SMMT in Q3 2025

Traded: +$131.7M
Buyers: 122
Sellers: 112
Total Bought: +$280.1M
Total Sold: −$148.4M
Avg Position: $7.7M

Biggest Buyers

Institution	Net Bought	Current Position
VANGUARD GROUP INC Institution	+$55.9M +2.7M shares	$235.1M 11.4M shares
STATE STREET CORP Institution	+$48.4M +2.3M shares	$131.4M 6.4M shares
MORGAN STANLEY RIA/Wealth	+$26.5M +1.3M shares	$39.8M 1.9M shares
N NOMURA HOLDINGS INC Institution	+$20.8M +1.0M shares	$21.7M 1.0M shares
PRICE T ROWE ASSOCIATES INC /MD/ Long Only Manager	+$13.1M +633.7K shares	$93.8M 4.5M shares
B BlackRock, Inc. Institution	+$10.7M +517.1K shares	$152.1M 7.4M shares
C Capricorn Fund Managers Ltd Institution	+$10.3M +496.3K shares	$10.3M 496.3K shares
TUDOR INVESTMENT CORP ET AL Hedge Fund•Multi-Strategy	+$7.2M +347.2K shares	$7.2M 347.2K shares
OZ MANAGEMENT LP Hedge Fund•Multi-Strategy	+$6.9M +333.5K shares	$6.9M 333.5K shares
T TANG CAPITAL MANAGEMENT LLC Institution	+$6.2M +300.0K shares	$11.4M 550.0K shares

Biggest Sellers

Institution	Net Sold	Current Position
UBS Group AG Institution	−$16.8M −815.2K shares	$26.4M 1.3M shares
Pictet Asset Management Holding SA Long Only Manager	−$11.7M −559.7K shares	$33.5M 1.6M shares
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	−$9.0M −435.5K shares	$2.5M 120.5K shares
SCHWAB CHARLES INVESTMENT MANAGEMENT INC Long Only Manager	−$8.6M −415.3K shares	$18.1M 876.4K shares
ROCKLAND TRUST CO Private Equity	−$8.5M −400.0K shares	Sold Off 0 shares
FMR LLC Institution	−$6.4M −308.5K shares	$184.2M 8.9M shares
Marshall Wace LLP Institution	−$5.8M −271.6K shares	Sold Off 0 shares
J JANE STREET GROUP, LLC Institution	−$5.3M −249.7K shares	Sold Off 0 shares
Polar Capital Holdings Plc Long Only Manager	−$5.2M −253.6K shares	$15.4M 746.4K shares
H HRT FINANCIAL LLC Institution	−$5.1M −241.7K shares	Sold Off 0 shares

Entry and Exit Activity

Institutions that initiated new positions or completely exited SMMT in Q3 2025

New Positions: 25
New Value: $23.3M
Exited Positions: 44
Exited Value: $63.7M

New Positions

Institution	Position Value
C Capricorn Fund Managers Ltd Institution	$10.3M 496.3K shares
OZ MANAGEMENT LP Hedge Fund•Multi-Strategy	$6.9M 333.5K shares
Y Yong Rong Asset Management Ltd Institution	$2.1M 100.0K shares
W Winton Capital Group Ltd Institution	$1.3M 64.9K shares
V Verde Servicos Internacionais S.A. Hedge Fund•Global Macro	$826.4K 40.0K shares
Beacon Pointe Advisors, LLC RIA/Wealth	$738.1K 35.7K shares
A AXQ CAPITAL, LP Hedge Fund•Market Neutral	$360.9K 17.5K shares
Q Qsemble Capital Management, LP Hedge Fund•Quant	$357.4K 17.3K shares
Q Quadrature Capital Ltd Institution	$242.1K 11.7K shares
Federation des caisses Desjardins du Quebec Fund of Funds	$192.2K 9.3K shares

Exited Positions

Institution	Previous Position
ROCKLAND TRUST CO Private Equity	$8.5M 400.0K shares
Marshall Wace LLP Institution	$5.8M 271.6K shares
J JANE STREET GROUP, LLC Institution	$5.3M 249.7K shares
H HRT FINANCIAL LLC Institution	$5.1M 241.7K shares
R READYSTATE ASSET MANAGEMENT LP Hedge Fund•Multi-Strategy	$4.8M 227.9K shares
T TWINBEECH CAPITAL LP Hedge Fund•Quant	$4.1M 191.1K shares
GRANAHAN INVESTMENT MANAGEMENT INC/MA Long Only Manager	$4.0M 185.6K shares
Sovran Advisors, LLC RIA/Wealth	$3.4M 150.0K shares
FRANKLIN RESOURCES INC Institution	$3.0M 139.1K shares
B BI Asset Management Fondsmaeglerselskab A/S Institution	$2.7M 125.1K shares

Options Activity

Institutions with the largest Call and Put options positions in SMMT as of Q3 2025

Call Positions: 17
Call Value: $97.5M
Put Positions: 15
Put Value: $82.9M

Call Positions

Institution	Position Value
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$25.2M 12.2K contracts
S Sofinnova Ventures Inc Venture Capital	$18.6M 9.0K contracts
S Squarepoint Ops LLC Hedge Fund•Quant	$16.2M 7.8K contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$12.3M 6.0K contracts
J JANE STREET GROUP, LLC Institution	$7.7M 3.7K contracts
Centiva Capital, LP Hedge Fund•Multi-Strategy	$4.4M 2.1K contracts
Caption Management, LLC Hedge Fund•Long/Short	$4.2M 2.1K contracts
W WOLVERINE TRADING, LLC Institution	$2.8M 1.3K contracts
N NOMURA HOLDINGS INC Institution	$2.3M 1.1K contracts
UBS Group AG Institution	$1.8M 850.0 contracts

Put Positions

Institution	Position Value
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$28.8M 13.9K contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$15.0M 7.3K contracts
J JANE STREET GROUP, LLC Institution	$8.5M 4.1K contracts
L LMR Partners LLP Institution	$8.5M 4.1K contracts
Affinity Asset Advisors, LLC Hedge Fund•Long/Short	$7.2M 3.5K contracts
OZ MANAGEMENT LP Hedge Fund•Multi-Strategy	$6.9M 3.3K contracts
Caption Management, LLC Hedge Fund•Long/Short	$2.6M 1.3K contracts
S Squarepoint Ops LLC Hedge Fund•Quant	$2.5M 1.2K contracts
W WOLVERINE TRADING, LLC Institution	$1.6M 744.0 contracts
N NOMURA HOLDINGS INC Institution	$1.2M 600.0 contracts

Most Committed Institutions

Institutions with SMMT as the highest % of their portfolio as of Q3 2025

Institution	Key People	Portfolio Weight	Ownership	Owned Since	Total AUM (Long)
APEIRON CAPITAL Ltd RIA/Wealth	James Michael Marsden Owner	12.87% $27.1M	0.18% 1.3M shares	Q2 2025 Held for 5 months	$210.4M
B BAKER BROS. ADVISORS LP Hedge Fund•Sector	Scott Lawrence Lessing President	6.45% $696.7M	4.54% 33.7M shares	Q2 2024 Held for 1y 5m	$10.8B
S SUPERSTRING CAPITAL MANAGEMENT LP Hedge Fund•Long/Short	Guo Ting Managing Partner	4.01% $4.1M	0.03% 197.3K shares	Q4 2024 Held for 11 months	$101.5M
C Capricorn Fund Managers Ltd Institution	-	3.44% $10.3M	0.07% 496.3K shares	Q3 2025 Held for 2 months	$297.8M
P Polymer Capital Management LTD Hedge Fund•Multi-Strategy	Eric Jay Kemnitz Managing Partner	2.34% $16.9M	0.11% 817.3K shares	Q4 2024 Held for 11 months	$721.2M
SECTORAL ASSET MANAGEMENT INC Venture Capital	Jerome Georges Pfund CEO	0.96% $1.5M	0.01% 74.1K shares	Q1 2023 Held for 2y 8m	$159.6M
Rock Springs Capital Management LP Hedge Fund•Sector	Nnamdi C Etoh CFO	0.86% $14.7M	0.10% 710.0K shares	Q3 2024 Held for 1y 2m	$1.7B
QVT Financial LP Hedge Fund•Multi-Strategy	Daniel Allen Gold CEO	0.85% $7.4M	0.05% 360.5K shares	Q2 2024 Held for 1y 5m	$873.7M
H HealthInvest Partners AB Institution	-	0.80% $203.4K	0.01% 92.7K shares	Q3 2024 Held for 1y 2m	$25.6M
P Polianta Ltd Institution	-	0.67% $1.5M	0.01% 74.7K shares	Q1 2025 Held for 8 months	$229.0M

Hedge Fund Spotlight

Discover hedge funds investing in SMMT

Squarepoint Ops LLC

Hedge Fund • Quant

Portfolio ManagerMichael Gottlieb

Portfolio Value: $46.9B
Positions: 2,529
Last Reported: Q3 2025

Sector Allocation

Position in Summit Therapeutics

Market Value: $2.3M
Shares Held: 109.8K
Portfolio Weight: 0.00%
Owned Since: 2024-Q1

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