Taysha Gene Therapies, Inc.

TSHA • NASDAQ

Taysha Gene Therapies, Inc. is a biotechnology company in the healthcare sector on NASDAQ, led by Sean Nolan, with a market cap of $1.6B. As of Q3 2025, 97% of shares are held by 150 institutional investors, with RTW INVESTMENTS, LLC as the largest holder at 8.93%.

Chief Executive OfficerSean Nolan

Market Cap$1.6B

Biotechnology

Healthcare

Employees52.0

Websitetayshagtx.com

Country

United States of America

Overview

Overview of institutional ownership in TSHA as of Q3 2025 with a market cap of $892.0M

All Institutions

Institutions: 150
Value Held: $865.4M
Shares Held: 264.6M
Avg Position: $5.8M
Median Position: $226.4K

Hedge Funds

Hedge Funds: 26
Value Held: $311.3M
Shares Held: 95.2M
Avg Position: $12.0M
Median Position: $2.2M

Ownership Breakdown

Institutional (non-HF)

62.12%

$554.1M

Hedge Funds

34.9%

$311.3M

Retail & Other

2.99%

$26.6M

Based on market cap of $892.0M as of Q3 2025. Institutional (non-HF) excludes hedge funds to avoid double counting.

Biggest Investors

Institutions with the largest positions in TSHA as of Q3 2025

Institution	Key People	Position Value	Ownership	Owned Since	Total AUM (Long)
RTW INVESTMENTS, LLC Hedge Fund•Sector	Peter M Fong President	$79.6M 0.99% of portfolio	8.93% 24.4M shares	Q3 2023 Held for 2y 2m	$8.1B
RA CAPITAL MANAGEMENT, LLC Hedge Fund•Long/Short	Michael Saulnier CFO	$77.0M 0.96% of portfolio	8.63% 23.6M shares	Q3 2023 Held for 2y 2m	$8.1B
venBio Select Advisor LLC RIA/Wealth	Behzad Aghazadeh Managing Partner	$71.0M 0.92% of portfolio	7.95% 21.7M shares	Q3 2023 Held for 2y 2m	$7.7B
MORGAN STANLEY RIA/Wealth	Jed Finn CEO	$63.1M 0.00% of portfolio	7.08% 19.3M shares	Q4 2020 Held for 4y 11m	$1.65T
B BlackRock, Inc. Institution	-	$53.5M 0.00% of portfolio	6.00% 16.4M shares	Q3 2020 Held for 5y 2m	$5.67T
FMR LLC Institution	-	$47.7M 0.00% of portfolio	5.35% 14.6M shares	Q3 2020 Held for 5y 2m	$1.92T
GOLDMAN SACHS GROUP INC Institution	David M. Solomon CEO	$43.8M 0.01% of portfolio	4.91% 13.4M shares	Q4 2023 Held for 1y 11m	$691.34B
VANGUARD GROUP INC Institution	Salim Ramji CEO	$42.0M 0.00% of portfolio	4.71% 12.8M shares	Q3 2020 Held for 5y 2m	$6.69T
S Siren, L.L.C. Institution	-	$36.0M 1.51% of portfolio	4.04% 11.0M shares	Q3 2024 Held for 1y 2m	$2.4B
Octagon Capital Advisors LP Hedge Fund•Sector	Ting (Nmn) Jia Founder	$29.7M 4.65% of portfolio	3.32% 9.1M shares	Q3 2023 Held for 2y 2m	$637.4M

Net Capital Flow

Institutional buying and selling activity for TSHA in Q3 2025

Traded: +$31.1M
Buyers: 89
Sellers: 52
Total Bought: +$113.0M
Total Sold: −$82.0M
Avg Position: $5.1M

Biggest Buyers

Institution	Net Bought	Current Position
BARCLAYS PLC Institution	+$15.4M +4.7M shares	$16.8M 5.1M shares
B BlackRock, Inc. Institution	+$10.0M +3.1M shares	$53.5M 16.4M shares
Affinity Asset Advisors, LLC Hedge Fund•Long/Short	+$9.2M +2.8M shares	$9.8M 3.0M shares
Vestal Point Capital, LP Hedge Fund•Long/Short	+$8.2M +2.5M shares	$18.0M 5.5M shares
MORGAN STANLEY RIA/Wealth	+$8.0M +2.4M shares	$63.1M 19.3M shares
D D. E. Shaw & Co., Inc. Institution	+$7.5M +2.3M shares	$8.9M 2.7M shares
STATE STREET CORP Institution	+$6.9M +2.1M shares	$23.7M 7.2M shares
VANGUARD GROUP INC Institution	+$6.4M +2.0M shares	$42.0M 12.8M shares
Ally Bridge Group LLC Hedge Fund•Sector	+$6.2M +1.9M shares	$6.2M 1.9M shares
GEODE CAPITAL MANAGEMENT LLC ETF Provider	+$4.5M +1.4M shares	$16.9M 5.2M shares

Biggest Sellers

Institution	Net Sold	Current Position
LEUCADIA NATIONAL CORP Institution	−$26.7M −8.2M shares	$7.1M 2.2M shares
Octagon Capital Advisors LP Hedge Fund•Sector	−$11.5M −3.5M shares	$29.7M 9.1M shares
TORONTO DOMINION BANK Institution	−$9.2M −2.8M shares	$6.3M 1.9M shares
SUVRETTA CAPITAL MANAGEMENT, LLC Hedge Fund•Long/Short	−$7.4M −3.2M shares	Sold Off 0 shares
MPM Oncology Impact Management LP Institution	−$6.8M −3.0M shares	Sold Off 0 shares
A ADAGE CAPITAL PARTNERS GP LLC Institution	−$4.9M −1.5M shares	$10.9M 3.3M shares
FMR LLC Institution	−$3.4M −1.0M shares	$47.7M 14.6M shares
RTW INVESTMENTS, LLC Hedge Fund•Sector	−$2.2M −667.3K shares	$79.6M 24.4M shares
Woodline Partners LP Hedge Fund•Long/Short	−$1.6M −500.3K shares	$1.6M 500.0K shares
T TYBOURNE CAPITAL MANAGEMENT HK LTD Institution	−$1.3M −395.0K shares	$12.1M 3.7M shares

Entry and Exit Activity

Institutions that initiated new positions or completely exited TSHA in Q3 2025

New Positions: 16
New Value: $12.1M
Exited Positions: 19
Exited Value: $16.3M

New Positions

Institution	Position Value
Ally Bridge Group LLC Hedge Fund•Sector	$6.2M 1.9M shares
R RICE HALL JAMES & ASSOCIATES, LLC Long Only Manager	$1.9M 578.1K shares
BOOTHBAY FUND MANAGEMENT, LLC Fund of Funds	$1.4M 415.6K shares
DIMENSIONAL FUND ADVISORS LP Long Only Manager	$1.1M 345.2K shares
R READYSTATE ASSET MANAGEMENT LP Hedge Fund•Multi-Strategy	$529.6K 162.0K shares
Palumbo Wealth Management LLC RIA/Wealth	$514.5K 157.4K shares
A AMERICAN CENTURY COMPANIES INC Institution	$126.1K 38.6K shares
S Sender Co & Partners, Inc. Institution	$88.7K 27.1K shares
R Russell Investments Group, Ltd. RIA/Wealth	$59.4K 18.2K shares
Cetera Investment Advisers RIA/Wealth	$52.9K 16.2K shares

Exited Positions

Institution	Previous Position
SUVRETTA CAPITAL MANAGEMENT, LLC Hedge Fund•Long/Short	$7.4M 3.2M shares
MPM Oncology Impact Management LP Institution	$6.8M 3.0M shares
X XTX Topco Ltd Institution	$740.9K 320.7K shares
ExodusPoint Capital Management, LP Hedge Fund•Multi-Strategy	$342.7K 148.4K shares
LOS ANGELES CAPITAL MANAGEMENT & EQUITY RESEARCH INC Long Only Manager	$272.0K 117.7K shares
O OMERS ADMINISTRATION Corp Institution	$168.4K 72.9K shares
E EntryPoint Capital, LLC Hedge Fund•Long/Short	$159.6K 69.1K shares
RENAISSANCE TECHNOLOGIES LLC Hedge Fund•Quant	$126.8K 54.9K shares
P Point72 Asia Pte. Ltd. Institution	$58.3K 25.3K shares
S STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM Institution	$52.4K 22.7K shares

Options Activity

Institutions with the largest Call and Put options positions in TSHA as of Q3 2025

Call Positions: 3
Call Value: $1.5M
Put Positions: 2
Put Value: $803.4K

Call Positions

Institution	Position Value
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	$1.3M 3.9K contracts
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$202.1K 618.0 contracts
J JANE STREET GROUP, LLC Institution	$43.8K 134.0 contracts

Put Positions

Institution	Position Value
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	$719.4K 2.2K contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$84.0K 257.0 contracts

Most Committed Institutions

Institutions with TSHA as the highest % of their portfolio as of Q3 2025

Institution	Key People	Portfolio Weight	Ownership	Owned Since	Total AUM (Long)
T TYBOURNE CAPITAL MANAGEMENT HK LTD Institution	-	39.11% $12.1M	1.36% 3.7M shares	Q3 2020 Held for 5y 2m	$30.9M
B B Group, Inc. Institution	-	6.80% $5.9M	0.66% 1.8M shares	Q4 2024 Held for 11 months	$86.6M
Ally Bridge Group LLC Hedge Fund•Sector	Slanix Paul T Alex President	5.20% $6.2M	0.70% 1.9M shares	Q3 2025 Held for 2 months	$119.4M
Octagon Capital Advisors LP Hedge Fund•Sector	Ting (Nmn) Jia Founder	4.65% $29.7M	3.32% 9.1M shares	Q3 2023 Held for 2y 2m	$637.4M
G GREAT POINT PARTNERS LLC Private Equity	Jeffrey Robert Jay Managing Partner	2.16% $4.9M	0.55% 1.5M shares	Q2 2025 Held for 5 months	$226.8M
L Longwood Capital Partners LLC Institution	-	1.54% $1.5M	0.17% 454.8K shares	Q3 2023 Held for 2y 2m	$96.8M
S Siren, L.L.C. Institution	-	1.51% $36.0M	4.04% 11.0M shares	Q3 2024 Held for 1y 2m	$2.4B
Affinity Asset Advisors, LLC Hedge Fund•Long/Short	Jonathan Bo-Shing Chu Founder	1.00% $9.8M	1.10% 3.0M shares	Q2 2025 Held for 5 months	$983.0M
RTW INVESTMENTS, LLC Hedge Fund•Sector	Peter M Fong President	0.99% $79.6M	8.93% 24.4M shares	Q3 2023 Held for 2y 2m	$8.1B
RA CAPITAL MANAGEMENT, LLC Hedge Fund•Long/Short	Michael Saulnier CFO	0.96% $77.0M	8.63% 23.6M shares	Q3 2023 Held for 2y 2m	$8.1B

Hedge Fund Spotlight

Discover hedge funds investing in TSHA

Engineers Gate Manager LP

Hedge Fund • Quant

Portfolio ManagerRobert Gregory Eisner

Portfolio Value: $8.8B
Positions: 2,112
Last Reported: Q3 2025

Sector Allocation

Position in Taysha Gene Therapies, Inc.

Market Value: $174.9K
Shares Held: 53.5K
Portfolio Weight: 0.00%
Owned Since: 2024-Q4

Top Holding	Sector	Market Value	Weight
1 Invesco QQQ Trust QQQ	ETF ETF	$155.2M	1.77%
2 SPDR S&P 500 ETF Trust SPY	ETF ETF	$115.3M	1.32%
3 Sabra Healthcare SBRA	REIT - Healthcare Facilities Real Estate	$112.9M	1.29%