Twist Bioscience Corporation

TWST • NASDAQ

Twist Bioscience Corporation is a medical - diagnostics & research company in the healthcare sector on NASDAQ, with a market cap of $1.9B. As of Q3 2025, 122% of shares are held by 233 institutional investors, with ARK Investment Management LLC as the largest holder at 11.14%.

Market Cap$1.9B

Medical - Diagnostics & Research

Healthcare

Employees919.0

Websitetwistbioscience.com

Country

United States of America

Overview

Overview of institutional ownership in TWST as of Q3 2025 with a market cap of $1.7B

All Institutions

Institutions: 233
Value Held: $2.1B
Shares Held: 73.8M
Avg Position: $8.9M
Median Position: $590.1K

Hedge Funds

Hedge Funds: 30
Value Held: $210.9M
Shares Held: 7.5M
Avg Position: $7.0M
Median Position: $1.5M

Ownership Breakdown

Institutional (non-HF)

109.77%

$1.9B

Hedge Funds

12.42%

$210.9M

Retail & Other

Based on market cap of $1.7B as of Q3 2025. Institutional (non-HF) excludes hedge funds to avoid double counting.

Biggest Investors

Institutions with the largest positions in TWST as of Q3 2025

Institution	Key People	Position Value	Ownership	Owned Since	Total AUM (Long)
ARK Investment Management LLC ETF Provider	Catherine Duddy Wood CEO	$189.3M 1.15% of portfolio	11.14% 6.7M shares	Q2 2019 Held for 6y 5m	$16.5B
Artisan Partners Limited Partnership Long Only Manager	Eric Richard Colson CEO	$180.4M 0.26% of portfolio	10.62% 6.4M shares	Q1 2023 Held for 2y 8m	$69.5B
B BlackRock, Inc. Institution	-	$173.9M 0.00% of portfolio	10.24% 6.2M shares	Q4 2018 Held for 6y 11m	$5.67T
VANGUARD GROUP INC Institution	Salim Ramji CEO	$162.3M 0.00% of portfolio	9.56% 5.8M shares	Q4 2018 Held for 6y 11m	$6.69T
WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC Long Only Manager	Brent Walker Gledhill CEO	$116.6M 0.30% of portfolio	6.86% 4.1M shares	Q1 2020 Held for 5y 8m	$38.7B
EdgePoint Investment Group Inc. Long Only Manager	Clifford Tye Bousada CEO	$114.9M 0.86% of portfolio	6.76% 4.1M shares	Q1 2025 Held for 8 months	$13.4B
STATE STREET CORP Institution	Ronald P. O'Hanley CEO	$86.9M 0.00% of portfolio	5.12% 3.1M shares	Q4 2018 Held for 6y 11m	$2.88T
S Sumitomo Mitsui Trust Holdings, Inc. Institution	-	$59.7M 0.03% of portfolio	3.51% 2.1M shares	Q1 2020 Held for 5y 8m	$173.79B
Nikko Asset Management Americas, Inc. Long Only Manager	James Mark Beyer Wesley CEO	$59.6M 0.58% of portfolio	3.51% 2.1M shares	Q1 2020 Held for 5y 8m	$10.3B
Soleus Capital Management, L.P. Hedge Fund•Long/Short	Guy Bezalel Levy CIO	$52.5M 2.87% of portfolio	3.09% 1.9M shares	Q2 2025 Held for 5 months	$1.8B

Net Capital Flow

Institutional buying and selling activity for TWST in Q3 2025

Traded: +$103.1M
Buyers: 130
Sellers: 98
Total Bought: +$308.3M
Total Sold: −$205.3M
Avg Position: $7.7M

Biggest Buyers

Institution	Net Bought	Current Position
EdgePoint Investment Group Inc. Long Only Manager	+$47.7M +1.7M shares	$114.9M 4.1M shares
Soleus Capital Management, L.P. Hedge Fund•Long/Short	+$42.5M +1.5M shares	$52.5M 1.9M shares
Artisan Partners Limited Partnership Long Only Manager	+$38.0M +1.3M shares	$180.4M 6.4M shares
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	+$30.4M +1.1M shares	$50.5M 1.8M shares
STATE STREET CORP Institution	+$16.5M +588.1K shares	$86.9M 3.1M shares
B BAILLIE GIFFORD & CO Institution	+$13.7M +487.1K shares	$35.5M 1.3M shares
ARK Investment Management LLC ETF Provider	+$9.2M +326.4K shares	$189.3M 6.7M shares
UBS Group AG Institution	+$8.4M +298.3K shares	$14.5M 514.9K shares
MORGAN STANLEY RIA/Wealth	+$8.2M +291.7K shares	$42.0M 1.5M shares
First Light Asset Management, LLC Hedge Fund•Sector	+$7.0M +249.9K shares	$33.6M 1.2M shares

Biggest Sellers

Institution	Net Sold	Current Position
Point72 Asset Management, L.P. Hedge Fund•Multi-Strategy	−$45.8M −1.6M shares	$14.9M 530.0K shares
ExodusPoint Capital Management, LP Hedge Fund•Multi-Strategy	−$17.4M −471.8K shares	Sold Off 0 shares
Iron Triangle Partners LP Hedge Fund•Long/Short	−$15.6M −424.4K shares	Sold Off 0 shares
Invesco Ltd. ETF Provider	−$15.6M −552.8K shares	$50.5M 1.8M shares
JPMORGAN CHASE & CO Institution	−$11.8M −420.9K shares	$28.7M 1.0M shares
BALYASNY ASSET MANAGEMENT LLC Hedge Fund•Multi-Strategy	−$10.7M −382.0K shares	$6.9M 246.2K shares
VICTORY CAPITAL MANAGEMENT INC Long Only Manager	−$8.8M −313.5K shares	$1.3M 47.2K shares
Hawk Ridge Management LLC Hedge Fund•Long/Short	−$8.6M −234.3K shares	Sold Off 0 shares
WELLINGTON MANAGEMENT CO LLP Long Only Manager	−$7.8M −277.3K shares	$8.4M 299.8K shares
BANK OF AMERICA CORP /DE/ Institution	−$6.7M −238.0K shares	$12.7M 450.4K shares

Entry and Exit Activity

Institutions that initiated new positions or completely exited TWST in Q3 2025

New Positions: 13
New Value: $3.9M
Exited Positions: 33
Exited Value: $59.9M

New Positions

Institution	Position Value
Prosight Management, LP Hedge Fund•Long/Short	$2.1M 75.0K shares
J JBF Capital, Inc. Institution	$1.0M 37.1K shares
B Bridgefront Capital, LLC Hedge Fund•Quant	$379.4K 13.5K shares
G GTS SECURITIES LLC Institution	$333.8K 11.9K shares
Point72 Europe LLP Digital Asset Manager	$48.3K 1.7K shares
Strategic Advocates LLC RIA/Wealth	$4.5K 161.0 shares
Halbert, Hargrove/Russell LLC RIA/Wealth	$3.0K 105.0 shares
C CBIZ Investment Advisory Services, LLC RIA/Wealth	$2.0K 70.0 shares
Guerra Advisors Inc RIA/Wealth	$563.0 20.0 shares
Transamerica Financial Advisors, Inc. Institution	$310.0 11.0 shares

Exited Positions

Institution	Previous Position
ExodusPoint Capital Management, LP Hedge Fund•Multi-Strategy	$17.4M 471.8K shares
Iron Triangle Partners LP Hedge Fund•Long/Short	$15.6M 424.4K shares
Hawk Ridge Management LLC Hedge Fund•Long/Short	$8.6M 234.3K shares
Hillsdale Investment Management Inc. Long Only Manager	$2.9M 77.6K shares
CAPITAL FUND MANAGEMENT S.A. Hedge Fund•Quant Macro	$2.5M 68.2K shares
PRINCIPAL FINANCIAL GROUP INC Institution	$2.5M 66.8K shares
Graham Capital Management, L.P. Hedge Fund•Multi-Strategy	$2.0M 53.9K shares
X XTX Topco Ltd Institution	$1.3M 35.3K shares
Holocene Advisors, LP Hedge Fund•Long/Short	$1.3M 34.6K shares
J JANE STREET GROUP, LLC Institution	$851.3K 23.1K shares

Options Activity

Institutions with the largest Call and Put options positions in TWST as of Q3 2025

Call Positions: 4
Call Value: $4.2M
Put Positions: 2
Put Value: $2.2M

Call Positions

Institution	Position Value
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$3.0M 1.1K contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$664.1K 236.0 contracts
J JANE STREET GROUP, LLC Institution	$574.1K 204.0 contracts
B BNP PARIBAS ARBITRAGE, SA Institution	- - contracts

Put Positions

Institution	Position Value
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$1.1M 385.0 contracts
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$1.1M 381.0 contracts

Most Committed Institutions

Institutions with TWST as the highest % of their portfolio as of Q3 2025

Institution	Key People	Portfolio Weight	Ownership	Owned Since	Total AUM (Long)
T Tao Capital Management LP Institution	-	17.65% $23.3M	1.37% 828.8K shares	Q4 2019 Held for 5y 11m	$132.1M
First Light Asset Management, LLC Hedge Fund•Sector	Mathew Paul Arens CEO	3.17% $33.6M	1.98% 1.2M shares	Q4 2024 Held for 11 months	$1.1B
Soleus Capital Management, L.P. Hedge Fund•Long/Short	Guy Bezalel Levy CIO	2.87% $52.5M	3.09% 1.9M shares	Q2 2025 Held for 5 months	$1.8B
ARK Investment Management LLC ETF Provider	Catherine Duddy Wood CEO	1.15% $189.3M	11.14% 6.7M shares	Q2 2019 Held for 6y 5m	$16.5B
EdgePoint Investment Group Inc. Long Only Manager	Clifford Tye Bousada CEO	0.86% $114.9M	6.76% 4.1M shares	Q1 2025 Held for 8 months	$13.4B
Nikko Asset Management Americas, Inc. Long Only Manager	James Mark Beyer Wesley CEO	0.58% $59.6M	3.51% 2.1M shares	Q1 2020 Held for 5y 8m	$10.3B
BRANDYWINE MANAGERS, LLC Fund of Funds	John Anthony Ciccarone President	0.57% $590.1K	0.03% 21.0K shares	Q4 2018 Held for 6y 11m	$104.2M
Prosight Management, LP Hedge Fund•Long/Short	William Lawrence Hawkins Managing Partner	0.56% $2.1M	0.12% 75.0K shares	Q3 2025 Held for 2 months	$376.7M
D Davy Asset Management Ltd Institution	-	0.51% $7.5M	0.44% 265.9K shares	Q2 2024 Held for 1y 5m	$1.5B
H HighMark Wealth Management LLC RIA/Wealth	Todd Edward Arens Managing Partner	0.49% $1.1M	0.07% 39.5K shares	Q4 2024 Held for 11 months	$227.1M

Hedge Fund Spotlight

Discover hedge funds investing in TWST

ALGERT COLDIRON INVESTORS LLC

Hedge Fund • Quant

Portfolio ManagerRyan Zentner Lafond

Portfolio Value: $6.0B
Positions: 1,110
Last Reported: Q3 2025

Sector Allocation

Position in Twist Bioscience Corporation

Market Value: $1.7M
Shares Held: 60.3K
Portfolio Weight: 0.03%
Owned Since: 2024-Q1

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