Tyra Biosciences, Inc.

TYRA • NASDAQ

Tyra Biosciences, Inc. is a biotechnology company in the healthcare sector on NASDAQ, led by Todd Harris, with a market cap of $1.2B. As of Q3 2025, 104% of shares are held by 114 institutional investors, with RA CAPITAL MANAGEMENT, LLC as the largest holder at 22.89%.

Chief Executive OfficerTodd Harris

Market Cap$1.2B

Biotechnology

Healthcare

Employees38.0

Websitetyra.bio

Country

United States of America

Overview

Overview of institutional ownership in TYRA as of Q3 2025 with a market cap of $745.6M

All Institutions

Institutions: 114
Value Held: $776.6M
Shares Held: 55.5M
Avg Position: $6.8M
Median Position: $450.2K

Hedge Funds

Hedge Funds: 24
Value Held: $357.1M
Shares Held: 25.5M
Avg Position: $14.9M
Median Position: $3.2M

Ownership Breakdown

Institutional (non-HF)

56.26%

$419.5M

Hedge Funds

47.89%

$357.1M

Retail & Other

Based on market cap of $745.6M as of Q3 2025. Institutional (non-HF) excludes hedge funds to avoid double counting.

Biggest Investors

Institutions with the largest positions in TYRA as of Q3 2025

Institution	Key People	Position Value	Ownership	Owned Since	Total AUM (Long)
RA CAPITAL MANAGEMENT, LLC Hedge Fund•Long/Short	Michael Saulnier CFO	$170.7M 2.12% of portfolio	22.89% 12.2M shares	Q3 2021 Held for 4y 2m	$8.1B
A Alta Partners Management Company, L.P. Institution	-	$57.1M 95.15% of portfolio	7.66% 4.1M shares	Q4 2024 Held for 11 months	$60.0M
N Nextech Invest, Ltd. Institution	-	$56.7M 8.64% of portfolio	7.61% 4.1M shares	Q1 2025 Held for 8 months	$657.0M
B BVF INC/IL Institution	-	$51.1M 2.07% of portfolio	6.85% 3.6M shares	Q3 2021 Held for 4y 2m	$2.5B
C Canaan Partners XI LLC Institution	-	$50.5M 49.07% of portfolio	6.77% 3.6M shares	Q4 2021 Held for 3y 11m	$102.9M
COMMODORE CAPITAL LP Hedge Fund•Long/Short	Michael Jonathan Kramarz Managing Partner	$47.2M 2.30% of portfolio	6.33% 3.4M shares	Q1 2025 Held for 8 months	$2.0B
TCG Crossover Management, LLC Venture Capital	Chen Ming Yu Managing Partner	$40.5M 2.02% of portfolio	5.44% 2.9M shares	Q4 2021 Held for 3y 11m	$2.0B
HENDERSON GROUP PLC Institution	Ali Dibadj CEO	$40.2M 0.02% of portfolio	5.39% 2.9M shares	Q3 2024 Held for 1y 2m	$218.74B
Vestal Point Capital, LP Hedge Fund•Long/Short	Ryan Christopher Wilder CIO	$33.9M 1.72% of portfolio	4.55% 2.4M shares	Q4 2024 Held for 11 months	$2.0B
K Kynam Capital Management, LP Hedge Fund•Long/Short	Jared Joseph Keller COO	$32.6M 2.43% of portfolio	4.37% 2.3M shares	Q4 2023 Held for 1y 11m	$1.3B

Net Capital Flow

Institutional buying and selling activity for TYRA in Q3 2025

Traded: −$9.2M
Buyers: 49
Sellers: 51
Total Bought: +$32.4M
Total Sold: −$41.7M
Avg Position: $6.0M

Biggest Buyers

Institution	Net Bought	Current Position
C Caligan Partners LP Hedge Fund•Activist	+$7.1M +506.9K shares	$9.7M 696.8K shares
COMMODORE CAPITAL LP Hedge Fund•Long/Short	+$3.8M +275.0K shares	$47.2M 3.4M shares
Eversept Partners, LLC Hedge Fund•Long/Short	+$3.8M +272.7K shares	$3.8M 272.7K shares
BALYASNY ASSET MANAGEMENT LLC Hedge Fund•Multi-Strategy	+$3.7M +263.2K shares	$11.8M 846.6K shares
BOOTHBAY FUND MANAGEMENT, LLC Fund of Funds	+$2.6M +186.7K shares	$2.6M 186.7K shares
Marshall Wace LLP Institution	+$2.4M +173.9K shares	$8.4M 602.0K shares
VANGUARD GROUP INC Institution	+$1.7M +118.5K shares	$21.3M 1.5M shares
TWO SIGMA INVESTMENTS LLC Hedge Fund•Multi-Strategy	+$1.3M +93.6K shares	$2.8M 199.4K shares
RAYMOND JAMES FINANCIAL INC RIA/Wealth	+$884.0K +63.2K shares	$1.8M 126.4K shares
Point72 Asset Management, L.P. Hedge Fund•Multi-Strategy	+$802.1K +57.3K shares	$3.9M 282.0K shares

Biggest Sellers

Institution	Net Sold	Current Position
ORBIMED ADVISORS LLC Hedge Fund•Sector	−$7.7M −804.6K shares	Sold Off 0 shares
Sio Capital Management, LLC Hedge Fund•Long/Short	−$4.1M −295.3K shares	$7.2M 514.9K shares
B BVF INC/IL Institution	−$4.1M −294.4K shares	$51.1M 3.6M shares
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	−$3.7M −263.4K shares	$2.0M 144.0K shares
BANK OF AMERICA CORP /DE/ Institution	−$3.3M −238.6K shares	$1.9M 134.3K shares
Vestal Point Capital, LP Hedge Fund•Long/Short	−$3.2M −230.0K shares	$33.9M 2.4M shares
JACOBS LEVY EQUITY MANAGEMENT, INC Hedge Fund•Quant	−$2.0M −143.7K shares	$3.5M 251.6K shares
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	−$1.5M −104.8K shares	$1.6M 111.3K shares
A AXA Institution	−$1.2M −128.4K shares	Sold Off 0 shares
C Cubist Systematic Strategies, LLC Institution	−$1.2M −82.7K shares	$549.9K 39.3K shares

Entry and Exit Activity

Institutions that initiated new positions or completely exited TYRA in Q3 2025

New Positions: 5
New Value: $4.0M
Exited Positions: 14
Exited Value: $12.2M

New Positions

Institution	Position Value
Eversept Partners, LLC Hedge Fund•Long/Short	$3.8M 272.7K shares
Invesco Ltd. ETF Provider	$217.0K 15.5K shares
O Optiver Holding B.V. Institution	$5.1K 368.0 shares
Rise Advisors, LLC RIA/Wealth	$686.0 49.0 shares
Farther Finance Advisors, LLC RIA/Wealth	$154.0 11.0 shares

Exited Positions

Institution	Previous Position
ORBIMED ADVISORS LLC Hedge Fund•Sector	$7.7M 804.6K shares
A AXA Institution	$1.2M 128.4K shares
Woodline Partners LP Hedge Fund•Long/Short	$958.0K 100.1K shares
ExodusPoint Capital Management, LP Hedge Fund•Multi-Strategy	$645.4K 67.4K shares
Verition Fund Management LLC Hedge Fund•Multi-Strategy	$391.8K 40.9K shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$361.6K 37.8K shares
D Dynamic Technology Lab Private Ltd Institution	$326.5K 34.1K shares
C Corton Capital Inc. Institution	$233.0K 24.3K shares
Aquatic Capital Management LLC Hedge Fund•Quant	$131.5K 13.7K shares
A AXQ CAPITAL, LP Hedge Fund•Market Neutral	$118.2K 12.4K shares

Options Activity

Institutions with the largest Call and Put options positions in TYRA as of Q3 2025

Call Positions: 1
Call Value: $328.8K
Put Positions: 0
Put Value: -

Call Positions

Institution	Position Value
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$328.8K 235.0 contracts

Put Positions

Institution	Position Value
No put positions found

Most Committed Institutions

Institutions with TYRA as the highest % of their portfolio as of Q3 2025

Institution	Key People	Portfolio Weight	Ownership	Owned Since	Total AUM (Long)
A Alta Partners Management Company, L.P. Institution	-	95.15% $57.1M	7.66% 4.1M shares	Q4 2024 Held for 11 months	$60.0M
C Canaan Partners XI LLC Institution	-	49.07% $50.5M	6.77% 3.6M shares	Q4 2021 Held for 3y 11m	$102.9M
N Nextech Invest, Ltd. Institution	-	8.64% $56.7M	7.61% 4.1M shares	Q1 2025 Held for 8 months	$657.0M
5 5AM Venture Management, LLC Institution	-	4.81% $13.1M	1.76% 939.3K shares	Q3 2023 Held for 2y 2m	$273.0M
K Kynam Capital Management, LP Hedge Fund•Long/Short	Jared Joseph Keller COO	2.43% $32.6M	4.37% 2.3M shares	Q4 2023 Held for 1y 11m	$1.3B
I INVESTMENT COUNSEL CO OF NEVADA Institution	-	2.42% $1.2M	0.16% 85.0K shares	Q4 2024 Held for 11 months	$49.1M
COMMODORE CAPITAL LP Hedge Fund•Long/Short	Michael Jonathan Kramarz Managing Partner	2.30% $47.2M	6.33% 3.4M shares	Q1 2025 Held for 8 months	$2.0B
RA CAPITAL MANAGEMENT, LLC Hedge Fund•Long/Short	Michael Saulnier CFO	2.12% $170.7M	22.89% 12.2M shares	Q3 2021 Held for 4y 2m	$8.1B
B BVF INC/IL Institution	-	2.07% $51.1M	6.85% 3.6M shares	Q3 2021 Held for 4y 2m	$2.5B
TCG Crossover Management, LLC Venture Capital	Chen Ming Yu Managing Partner	2.02% $40.5M	5.44% 2.9M shares	Q4 2021 Held for 3y 11m	$2.0B

Hedge Fund Spotlight

Discover hedge funds investing in TYRA

BAKER BROS. ADVISORS LP

Hedge Fund • Sector

Portfolio ManagerScott Lawrence Lessing

Portfolio Value: $10.8B
Positions: 88
Last Reported: Q3 2025

Sector Allocation

Position in Tyra Biosciences, Inc.

Market Value: $148.4K
Shares Held: 10.6K
Portfolio Weight: 0.00%
Owned Since: 2023-Q4

Top Holding	Sector	Market Value	Weight
1 Incyte INCY	Biotechnology Healthcare	$2.6B	24.14%
2 Madrigal Pharmaceuticals, Inc. MDGL	Biotechnology Healthcare	$982.3M	9.10%
3 Insmed INSM	Biotechnology Healthcare	$965.4M	8.94%