Opko Health

OPK • NASDAQ

Opko Health is a medical - diagnostics & research company in the healthcare sector on NASDAQ, led by Phillip Frost, with a market cap of $1.1B. As of Q3 2025, 25% of shares are held by 222 institutional investors, with Rubric Capital Management LP as the largest holder at 6.02%.

CEO & Chairman of the BoardPhillip Frost

Market Cap$1.1B

Medical - Diagnostics & Research

Healthcare

Employees3.9K

Websiteopko.com

Country

United States of America

Overview

Overview of institutional ownership in OPK as of Q3 2025 with a market cap of $1.2B

All Institutions

Institutions: 222
Value Held: $303.1M
Shares Held: 195.7M
Avg Position: $1.4M
Median Position: $62.7K

Hedge Funds

Hedge Funds: 19
Value Held: $97.6M
Shares Held: 63.0M
Avg Position: $5.1M
Median Position: $379.5K

Ownership Breakdown

Institutional (non-HF)

16.71%

$205.5M

Hedge Funds

7.93%

$97.6M

Retail & Other

75.36%

$927.2M

Based on market cap of $1.2B as of Q3 2025. Institutional (non-HF) excludes hedge funds to avoid double counting.

Biggest Investors

Institutions with the largest positions in OPK as of Q3 2025

Institution	Key People	Position Value	Ownership	Owned Since	Total AUM (Long)
R Rubric Capital Management LP Hedge Fund•Long/Short	Margaret Kossakowski CFO	$74.1M 1.07% of portfolio	6.02% 47.8M shares	Q1 2024 Held for 1y 8m	$6.9B
VANGUARD GROUP INC Institution	Salim Ramji CEO	$58.2M 0.00% of portfolio	4.73% 37.5M shares	≤ Q2 2013 Held for 12y 5m+	$6.69T
B BlackRock, Inc. Institution	-	$51.4M 0.00% of portfolio	4.18% 33.2M shares	≤ Q2 2013 Held for 12y 5m+	$5.67T
GEODE CAPITAL MANAGEMENT LLC ETF Provider	David Kenneth Lane CEO	$17.0M 0.00% of portfolio	1.38% 11.0M shares	≤ Q2 2013 Held for 12y 5m+	$1.57T
STATE STREET CORP Institution	Ronald P. O'Hanley CEO	$13.9M 0.00% of portfolio	1.13% 9.0M shares	≤ Q2 2013 Held for 12y 5m+	$2.88T
W Whitefort Capital Management, LP Hedge Fund•Event Driven	David Lorin Salanic Managing Partner	$7.6M 2.64% of portfolio	0.62% 4.9M shares	Q2 2024 Held for 1y 5m	$287.7M
UBS Group AG Institution	Sergio P. Ermotti CEO	$7.4M 0.00% of portfolio	0.60% 4.8M shares	Q4 2014 Held for 10y 11m	$511.54B
SCHWAB CHARLES INVESTMENT MANAGEMENT INC Long Only Manager	Omar Aguilar Chavez CEO	$5.8M 0.00% of portfolio	0.47% 3.8M shares	≤ Q2 2013 Held for 12y 5m+	$620.51B
NORTHERN TRUST CORP Institution	Michael G. O'Grady CEO	$5.7M 0.00% of portfolio	0.46% 3.7M shares	≤ Q2 2013 Held for 12y 5m+	$782.01B
AQR CAPITAL MANAGEMENT LLC Hedge Fund•Multi-Strategy	David Gary Kabiller Founder	$4.5M 0.00% of portfolio	0.36% 2.9M shares	Q3 2020 Held for 5y 2m	$156.17B

Net Capital Flow

Institutional buying and selling activity for OPK in Q3 2025

Traded: −$9.5M
Buyers: 105
Sellers: 62
Total Bought: +$17.5M
Total Sold: −$26.9M
Avg Position: $1.3M

Biggest Buyers

Institution	Net Bought	Current Position
W Whitefort Capital Management, LP Hedge Fund•Event Driven	+$4.8M +3.1M shares	$7.6M 4.9M shares
AQR CAPITAL MANAGEMENT LLC Hedge Fund•Multi-Strategy	+$3.0M +1.9M shares	$4.5M 2.9M shares
B BlackRock, Inc. Institution	+$2.7M +1.7M shares	$51.4M 33.2M shares
GEODE CAPITAL MANAGEMENT LLC ETF Provider	+$881.9K +568.9K shares	$17.0M 11.0M shares
SCHWAB CHARLES INVESTMENT MANAGEMENT INC Long Only Manager	+$648.8K +418.6K shares	$5.8M 3.8M shares
STATE STREET CORP Institution	+$645.0K +416.1K shares	$13.9M 9.0M shares
S Swiss National Bank Institution	+$416.0K +268.4K shares	$1.3M 845.8K shares
A AWM Investment Company, Inc. Hedge Fund•Event Driven	+$310.0K +200.0K shares	$3.4M 2.2M shares
NORTHERN TRUST CORP Institution	+$272.1K +175.6K shares	$5.7M 3.7M shares
IEQ CAPITAL, LLC RIA/Wealth	+$261.0K +168.4K shares	$430.3K 277.6K shares

Biggest Sellers

Institution	Net Sold	Current Position
Weiss Asset Management LP Hedge Fund•Multi-Strategy	−$5.6M −3.6M shares	$1.8M 1.1M shares
Marshall Wace LLP Institution	−$4.4M −3.3M shares	Sold Off 0 shares
MORGAN STANLEY RIA/Wealth	−$1.9M −1.2M shares	$1.3M 837.6K shares
J JANE STREET GROUP, LLC Institution	−$1.7M −1.1M shares	$407.4K 262.8K shares
UBS Group AG Institution	−$1.5M −944.1K shares	$7.4M 4.8M shares
Hartland & Co., LLC RIA/Wealth	−$1.2M −883.0K shares	Sold Off 0 shares
VANGUARD GROUP INC Institution	−$1.1M −702.8K shares	$58.2M 37.5M shares
BANK OF AMERICA CORP /DE/ Institution	−$919.1K −593.0K shares	$2.0M 1.3M shares
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	−$918.4K −695.8K shares	Sold Off 0 shares
TWO SIGMA INVESTMENTS LLC Hedge Fund•Multi-Strategy	−$900.7K −581.1K shares	$1.9M 1.3M shares

Entry and Exit Activity

Institutions that initiated new positions or completely exited OPK in Q3 2025

New Positions: 10
New Value: $177.4K
Exited Positions: 14
Exited Value: $6.9M

New Positions

Institution	Position Value
E EntryPoint Capital, LLC Hedge Fund•Long/Short	$60.2K 38.8K shares
ARROW FINANCIAL CORP Institution	$38.8K 25.0K shares
Buckingham Strategic Partners RIA/Wealth	$25.8K 18.0K shares
U Universal- Beteiligungs- und Servicegesellschaft mbH Institution	$23.0K 14.8K shares
N NorthCrest Asset Manangement, LLC Long Only Manager	$19.2K 12.5K shares
Sontag Advisory, LLC RIA/Wealth	$5.7K 3.7K shares
O Optiver Holding B.V. Institution	$4.3K 2.8K shares
Transamerica Financial Advisors, Inc. Institution	$290.0 187.0 shares
R Root Financial Partners, LLC RIA/Wealth	$155.0 100.0 shares
Guerra Advisors Inc RIA/Wealth	$2.0 1.0 shares

Exited Positions

Institution	Previous Position
Marshall Wace LLP Institution	$4.4M 3.3M shares
Hartland & Co., LLC RIA/Wealth	$1.2M 883.0K shares
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	$918.4K 695.8K shares
INTREPID CAPITAL MANAGEMENT INC Hedge Fund•Value	$132.0K 100.0K shares
X XTX Topco Ltd Institution	$112.1K 84.9K shares
Engineers Gate Manager LP Hedge Fund•Quant	$72.8K 55.1K shares
H HSBC HOLDINGS PLC Institution	$46.3K 34.9K shares
K Kapitalo Investimentos Ltda Institution	$41.4K 31.3K shares
Janney Montgomery Scott LLC RIA/Wealth	$16.5K 12.5K shares
R Raiffeisen Bank International AG Institution	$8.6K 6.5K shares

Options Activity

Institutions with the largest Call and Put options positions in OPK as of Q3 2025

Call Positions: 7
Call Value: $2.6M
Put Positions: 3
Put Value: $195.6K

Call Positions

Institution	Position Value
Hartland & Co., LLC RIA/Wealth	$1.4M 9.0K contracts
Caption Management, LLC Hedge Fund•Long/Short	$475.5K 3.1K contracts
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$308.6K 2.0K contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$196.9K 1.3K contracts
S Squarepoint Ops LLC Hedge Fund•Quant	$143.4K 925.0 contracts
J JANE STREET GROUP, LLC Institution	$71.6K 462.0 contracts
R Raiffeisen Bank International AG Institution	$10.1K 65.2 contracts

Put Positions

Institution	Position Value
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$119.4K 770.0 contracts
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$51.3K 331.0 contracts
S Squarepoint Ops LLC Hedge Fund•Quant	$25.0K 161.0 contracts

Most Committed Institutions

Institutions with OPK as the highest % of their portfolio as of Q3 2025

Institution	Key People	Portfolio Weight	Ownership	Owned Since	Total AUM (Long)
W Whitefort Capital Management, LP Hedge Fund•Event Driven	David Lorin Salanic Managing Partner	2.64% $7.6M	0.62% 4.9M shares	Q2 2024 Held for 1y 5m	$287.7M
W WASHINGTON GROWTH STRATEGIES LLC Hedge Fund•Multi-Strategy	Coe Milton Magruder CEO	1.50% $2.1M	0.17% 1.4M shares	Q1 2025 Held for 8 months	$140.3M
R Rubric Capital Management LP Hedge Fund•Long/Short	Margaret Kossakowski CFO	1.07% $74.1M	6.02% 47.8M shares	Q1 2024 Held for 1y 8m	$6.9B
T Tejara Capital Ltd Institution	-	0.75% $1.4M	0.11% 877.9K shares	Q2 2024 Held for 1y 5m	$182.4M
ZAZOVE ASSOCIATES LLC Hedge Fund•Multi-Strategy	Gene Thomas Pretti CEO	0.64% $321.8K	0.03% 207.6K shares	Q4 2024 Held for 11 months	$49.9M
A AWM Investment Company, Inc. Hedge Fund•Event Driven	David Michael Greenhouse President	0.32% $3.4M	0.28% 2.2M shares	Q4 2014 Held for 10y 11m	$1.1B
Y Y.D. More Investments Ltd Institution	-	0.13% $2.2M	0.19% 1.5M shares	Q2 2024 Held for 1y 5m	$1.7B
P PFG Investments, LLC Institution	-	0.11% $2.1M	0.17% 1.3M shares	Q1 2024 Held for 1y 8m	$1.9B
R RK Asset Management, LLC Institution	-	0.06% $62.8K	0.01% 40.5K shares	Q4 2022 Held for 2y 11m	$110.0M
HIGHLINE WEALTH PARTNERS LLC RIA/Wealth	Jonathan Christopher Rugg President	0.05% $180.9K	0.01% 116.7K shares	Q3 2022 Held for 3y 2m	$371.5M

Hedge Fund Spotlight

Discover hedge funds investing in OPK

Weiss Asset Management LP

Hedge Fund • Multi-Strategy

Portfolio ManagerAndrew Murray Weiss

Portfolio Value: $5.2B
Positions: 533
Last Reported: Q3 2025

Sector Allocation

Position in Opko Health

Market Value: $1.8M
Shares Held: 1.1M
Portfolio Weight: 0.03%
Owned Since: 2025-Q1

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