Pyxis Oncology

PYXS • NASDAQ

Pyxis Oncology is a biotechnology company in the healthcare sector on NASDAQ, led by Lara Sullivan, M.D., with a market cap of $261.5M. As of Q3 2025, 43% of shares are held by 73 institutional investors, with PFIZER INC as the largest holder at 11.34%.

Chief Executive OfficerLara Sullivan, M.D.

Market Cap$261.5M

Biotechnology

Healthcare

Employees51.0

Websitepyxisoncology.com

Country

United States of America

Overview

Overview of institutional ownership in PYXS as of Q3 2025 with a market cap of $137.7M

All Institutions

Institutions: 73
Value Held: $59.7M
Shares Held: 26.8M
Avg Position: $818.4K
Median Position: $116.6K

Hedge Funds

Hedge Funds: 17
Value Held: $21.9M
Shares Held: 9.9M
Avg Position: $1.3M
Median Position: $748.9K

Ownership Breakdown

Institutional (non-HF)

27.49%

$37.9M

Hedge Funds

15.9%

$21.9M

Retail & Other

56.61%

$77.9M

Based on market cap of $137.7M as of Q3 2025. Institutional (non-HF) excludes hedge funds to avoid double counting.

Biggest Investors

Institutions with the largest positions in PYXS as of Q3 2025

Institution	Key People	Position Value	Ownership	Owned Since	Total AUM (Long)
PFIZER INC Institution	Albert Bourla CEO	$15.6M 3.57% of portfolio	11.34% 7.0M shares	Q4 2024 Held for 11 months	$437.4M
Laurion Capital Management LP Hedge Fund•Multi-Strategy	Masih Mohebbi-Forushani CFO	$8.0M 1.18% of portfolio	5.85% 3.6M shares	Q4 2021 Held for 3y 11m	$679.7M
T TANG CAPITAL MANAGEMENT LLC Institution	-	$5.6M 0.22% of portfolio	4.03% 2.5M shares	Q1 2025 Held for 8 months	$2.5B
VANGUARD GROUP INC Institution	Salim Ramji CEO	$4.8M 0.00% of portfolio	3.49% 2.2M shares	Q4 2021 Held for 3y 11m	$6.69T
PERCEPTIVE ADVISORS LLC Hedge Fund•Long/Short	Joseph Eric Edelman CEO	$2.6M 0.08% of portfolio	1.90% 1.2M shares	Q3 2025 Held for 2 months	$3.5B
P Palo Alto Investors, LLC Hedge Fund•Long/Short	Angela Elizabeth Nguyen-Dinh CCO	$2.3M 0.43% of portfolio	1.67% 1.0M shares	Q3 2024 Held for 1y 2m	$540.4M
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	Dan Michael Berkovitz Chairman	$1.8M 0.00% of portfolio	1.31% 815.3K shares	Q4 2021 Held for 3y 11m	$121.98B
StemPoint Capital LP Hedge Fund•Long/Short	Sean Chua Tan President	$1.5M 0.31% of portfolio	1.11% 689.5K shares	Q3 2025 Held for 2 months	$495.9M
B BlackRock, Inc. Institution	-	$1.5M 0.00% of portfolio	1.10% 683.7K shares	Q4 2021 Held for 3y 11m	$5.67T
BANK OF AMERICA CORP /DE/ Institution	Brian T. Moynihan CEO	$1.4M 0.00% of portfolio	0.99% 615.9K shares	Q4 2021 Held for 3y 11m	$1.33T

Net Capital Flow

Institutional buying and selling activity for PYXS in Q3 2025

Traded: +$102.6K
Buyers: 26
Sellers: 46
Total Bought: +$10.0M
Total Sold: −$9.9M
Avg Position: $671.3K

Biggest Buyers

Institution	Net Bought	Current Position
PERCEPTIVE ADVISORS LLC Hedge Fund•Long/Short	+$2.6M +1.2M shares	$2.6M 1.2M shares
StemPoint Capital LP Hedge Fund•Long/Short	+$1.5M +689.5K shares	$1.5M 689.5K shares
BANK OF AMERICA CORP /DE/ Institution	+$1.3M +593.9K shares	$1.4M 615.9K shares
L Longaeva Partners L.P. Institution	+$1.1M +503.2K shares	$1.1M 503.2K shares
DRIEHAUS CAPITAL MANAGEMENT LLC Hedge Fund•Event Driven	+$929.4K +418.6K shares	$929.4K 418.6K shares
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	+$748.9K +337.4K shares	$748.9K 337.4K shares
RENAISSANCE TECHNOLOGIES LLC Hedge Fund•Quant	+$351.9K +158.5K shares	$1.3M 576.3K shares
DIADEMA PARTNERS LP Hedge Fund•Long/Short	+$333.0K +150.0K shares	$333.0K 150.0K shares
Walleye Trading Advisors, LLC Hedge Fund•Multi-Strategy	+$265.4K +119.6K shares	$265.4K 119.6K shares
JACOBS LEVY EQUITY MANAGEMENT, INC Hedge Fund•Quant	+$133.9K +60.3K shares	$133.9K 60.3K shares

Biggest Sellers

Institution	Net Sold	Current Position
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	−$6.0M −2.7M shares	$1.8M 815.3K shares
S Standard Life Aberdeen plc Institution	−$1.0M −913.0K shares	Sold Off 0 shares
B BlackRock, Inc. Institution	−$539.7K −243.1K shares	$1.5M 683.7K shares
PIER 88 INVESTMENT PARTNERS LLC Hedge Fund•Long/Short	−$478.3K −215.4K shares	$336.8K 151.7K shares
GOLDMAN SACHS GROUP INC Institution	−$219.4K −98.8K shares	$278.5K 125.5K shares
FMR LLC Institution	−$176.2K −79.4K shares	$34.3K 15.5K shares
Marshall Wace LLP Institution	−$162.5K −147.8K shares	Sold Off 0 shares
AQR CAPITAL MANAGEMENT LLC Hedge Fund•Multi-Strategy	−$161.9K −72.9K shares	$30.7K 13.8K shares
Q Qube Research & Technologies Ltd Institution	−$160.4K −72.3K shares	$68.4K 30.8K shares
Y Y-Intercept Ltd Institution	−$146.4K −133.0K shares	Sold Off 0 shares

Entry and Exit Activity

Institutions that initiated new positions or completely exited PYXS in Q3 2025

New Positions: 6
New Value: $2.5M
Exited Positions: 16
Exited Value: $1.5M

New Positions

Institution	Position Value
L Longaeva Partners L.P. Institution	$1.1M 503.2K shares
DRIEHAUS CAPITAL MANAGEMENT LLC Hedge Fund•Event Driven	$929.4K 418.6K shares
DIADEMA PARTNERS LP Hedge Fund•Long/Short	$333.0K 150.0K shares
P Persistent Asset Partners Ltd Institution	$76.9K 34.6K shares
PRUDENTIAL FINANCIAL INC Institution	$36.2K 16.3K shares
SRS Capital Advisors, Inc. RIA/Wealth	$31.0 14.0 shares

Exited Positions

Institution	Previous Position
S Standard Life Aberdeen plc Institution	$1.0M 913.0K shares
Marshall Wace LLP Institution	$162.5K 147.8K shares
Y Y-Intercept Ltd Institution	$146.4K 133.0K shares
Jain Global LLC Hedge Fund•Multi-Strategy	$53.5K 48.6K shares
S Squarepoint Ops LLC Hedge Fund•Quant	$39.0K 35.4K shares
Kingstone Capital Partners Texas, LLC RIA/Wealth	$37.0K 33.6K shares
C Catalyst Funds Management Pty Ltd Institution	$25.5K 23.2K shares
Hudson Bay Capital Management LP Hedge Fund•Multi-Strategy	$15.2K 13.8K shares
D DRW Securities, LLC Institution	$14.3K 13.0K shares
Q Quadrature Capital Ltd Institution	$13.6K 12.3K shares

Options Activity

Institutions with the largest Call and Put options positions in PYXS as of Q3 2025

Call Positions: 1
Call Value: $47.7K
Put Positions: 0
Put Value: -

Call Positions

Institution	Position Value
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$47.7K 215.0 contracts

Put Positions

Institution	Position Value
No put positions found

Most Committed Institutions

Institutions with PYXS as the highest % of their portfolio as of Q3 2025

Institution	Key People	Portfolio Weight	Ownership	Owned Since	Total AUM (Long)
PFIZER INC Institution	Albert Bourla CEO	3.57% $15.6M	11.34% 7.0M shares	Q4 2024 Held for 11 months	$437.4M
Laurion Capital Management LP Hedge Fund•Multi-Strategy	Masih Mohebbi-Forushani CFO	1.18% $8.0M	5.85% 3.6M shares	Q4 2021 Held for 3y 11m	$679.7M
P Palo Alto Investors, LLC Hedge Fund•Long/Short	Angela Elizabeth Nguyen-Dinh CCO	0.43% $2.3M	1.67% 1.0M shares	Q3 2024 Held for 1y 2m	$540.4M
PIER 88 INVESTMENT PARTNERS LLC Hedge Fund•Long/Short	Francis Thomas Timons CEO	0.36% $336.8K	0.24% 151.7K shares	Q1 2024 Held for 1y 8m	$94.4M
StemPoint Capital LP Hedge Fund•Long/Short	Sean Chua Tan President	0.31% $1.5M	1.11% 689.5K shares	Q3 2025 Held for 2 months	$495.9M
SCHULHOFF & CO INC RIA/Wealth	John Meiser Schulhoff President	0.27% $610.5K	0.44% 275.0K shares	Q3 2023 Held for 2y 2m	$228.0M
L Longaeva Partners L.P. Institution	-	0.24% $1.1M	0.81% 503.2K shares	Q3 2025 Held for 2 months	$467.6M
DIADEMA PARTNERS LP Hedge Fund•Long/Short	Timothy Beau Bassett CIO	0.23% $333.0K	0.24% 150.0K shares	Q3 2025 Held for 2 months	$143.3M
T TANG CAPITAL MANAGEMENT LLC Institution	-	0.22% $5.6M	4.03% 2.5M shares	Q1 2025 Held for 8 months	$2.5B
Decheng Capital LLC Venture Capital	Xiangmin Nmn Cui Managing Partner	0.13% $725.5K	0.53% 326.8K shares	Q4 2023 Held for 1y 11m	$573.2M

Hedge Fund Spotlight

Discover hedge funds investing in PYXS

StemPoint Capital LP

Hedge Fund • Long/Short

Portfolio ManagerSean Chua Tan

Portfolio Value: $495.9M
Positions: 76
Last Reported: Q3 2025

Sector Allocation

Position in Pyxis Oncology

Market Value: $1.5M
Shares Held: 689.5K
Portfolio Weight: 0.31%
Owned Since: 2025-Q3

Top Holding	Sector	Market Value	Weight
1 Roivant Sciences ROIV	Biotechnology Healthcare	$63.5M	12.81%
2 uniQure QURE	Biotechnology Healthcare	$30.5M	6.15%
3 Scholar Rock SRRK	Biotechnology Healthcare	$27.0M	5.45%