Spyre Therapeutics, Inc.

SYRE • NASDAQ

Spyre Therapeutics, Inc. is a biotechnology company in the healthcare sector on NASDAQ, led by Cameron Turtle, with a market cap of $2.6B. As of Q3 2025, 106% of shares are held by 136 institutional investors, with FMR LLC as the largest holder at 15.0%.

Chief Executive OfficerCameron Turtle

Market Cap$2.6B

Biotechnology

Healthcare

Employees30.0

Websitespyre.com

Country

United States of America

Overview

Overview of institutional ownership in SYRE as of Q3 2025 with a market cap of $1.0B

All Institutions

Institutions: 136
Value Held: $1.1B
Shares Held: 64.3M
Avg Position: $7.9M
Median Position: $723.5K

Hedge Funds

Hedge Funds: 24
Value Held: $361.8M
Shares Held: 21.6M
Avg Position: $15.1M
Median Position: $3.9M

Ownership Breakdown

Institutional (non-HF)

70.71%

$715.8M

Hedge Funds

35.74%

$361.8M

Retail & Other

Based on market cap of $1.0B as of Q3 2025. Institutional (non-HF) excludes hedge funds to avoid double counting.

Biggest Investors

Institutions with the largest positions in SYRE as of Q3 2025

Institution	Key People	Position Value	Ownership	Owned Since	Total AUM (Long)
FMR LLC Institution	-	$151.8M 0.01% of portfolio	15.00% 9.1M shares	Q4 2023 Held for 1y 11m	$1.92T
Fairmount Funds Management LLC Hedge Fund•Sector	Peter Evan Harwin Managing Partner	$67.3M 6.06% of portfolio	6.65% 4.0M shares	Q4 2023 Held for 1y 11m	$1.1B
B BlackRock, Inc. Institution	-	$66.8M 0.00% of portfolio	6.59% 4.0M shares	Q4 2023 Held for 1y 11m	$5.67T
RTW INVESTMENTS, LLC Hedge Fund•Sector	Peter M Fong President	$60.7M 0.75% of portfolio	6.00% 3.6M shares	Q4 2023 Held for 1y 11m	$8.1B
T TANG CAPITAL MANAGEMENT LLC Institution	-	$53.6M 2.11% of portfolio	5.30% 3.2M shares	Q1 2025 Held for 8 months	$2.5B
VANGUARD GROUP INC Institution	Salim Ramji CEO	$51.1M 0.00% of portfolio	5.05% 3.1M shares	Q3 2023 Held for 2y 2m	$6.69T
VR Adviser, LLC Venture Capital	Jessica Tong Baron CFO	$45.0M 2.53% of portfolio	4.45% 2.7M shares	Q4 2023 Held for 1y 11m	$1.8B
B BRAIDWELL LP Hedge Fund•Multi-Strategy	Brian James Kreiter CEO	$43.2M 1.75% of portfolio	4.27% 2.6M shares	Q4 2023 Held for 1y 11m	$2.5B
C Capital International Investors Institution	-	$40.1M 0.01% of portfolio	3.96% 2.4M shares	Q1 2025 Held for 8 months	$615.90B
DRIEHAUS CAPITAL MANAGEMENT LLC Hedge Fund•Event Driven	Stephen Thomas Weber CEO	$34.5M 0.25% of portfolio	3.41% 2.1M shares	Q4 2023 Held for 1y 11m	$13.9B

Net Capital Flow

Institutional buying and selling activity for SYRE in Q3 2025

Traded: +$13.8M
Buyers: 66
Sellers: 56
Total Bought: +$76.1M
Total Sold: −$62.4M
Avg Position: $7.1M

Biggest Buyers

Institution	Net Bought	Current Position
TCG Crossover Management, LLC Venture Capital	+$18.4M +1.1M shares	$18.4M 1.1M shares
Affinity Asset Advisors, LLC Hedge Fund•Long/Short	+$13.6M +812.6K shares	$23.8M 1.4M shares
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	+$6.8M +408.2K shares	$6.8M 408.2K shares
B BAKER BROS. ADVISORS LP Hedge Fund•Sector	+$6.3M +373.3K shares	$16.8M 1.0M shares
JPMORGAN CHASE & CO Institution	+$3.8M +228.7K shares	$4.6M 276.0K shares
Parkman Healthcare Partners LLC Hedge Fund•Long/Short	+$3.4M +200.8K shares	$3.4M 200.8K shares
STATE STREET CORP Institution	+$3.2M +189.9K shares	$29.9M 1.8M shares
Candriam Luxembourg S.C.A. Long Only Manager	+$2.7M +158.3K shares	$6.8M 404.4K shares
WELLINGTON MANAGEMENT CO LLP Long Only Manager	+$2.1M +126.8K shares	$27.5M 1.6M shares
HighVista Strategies LLC Fund of Funds	+$1.7M +102.9K shares	$3.6M 215.7K shares

Biggest Sellers

Institution	Net Sold	Current Position
A ADAGE CAPITAL PARTNERS GP LLC Institution	−$9.1M −610.2K shares	Sold Off 0 shares
Paradigm Biocapital Advisors LP Hedge Fund•Long/Short	−$6.8M −403.2K shares	$24.6M 1.5M shares
MORGAN STANLEY RIA/Wealth	−$5.6M −336.3K shares	$5.6M 334.7K shares
Woodline Partners LP Hedge Fund•Long/Short	−$5.6M −333.3K shares	$2.2M 131.9K shares
PRICE T ROWE ASSOCIATES INC /MD/ Long Only Manager	−$5.2M −309.9K shares	$10.4M 620.6K shares
PERCEPTIVE ADVISORS LLC Hedge Fund•Long/Short	−$5.0M −300.0K shares	$20.6M 1.2M shares
Deep Track Capital, LP Hedge Fund•Long/Short	−$3.3M −219.0K shares	Sold Off 0 shares
GOLDMAN SACHS GROUP INC Institution	−$3.2M −193.9K shares	$5.5M 329.5K shares
C Capitolis Liquid Global Markets LLC Private Equity	−$2.7M −183.0K shares	Sold Off 0 shares
C Capital World Investors Institution	−$2.5M −150.6K shares	$3.4M 200.2K shares

Entry and Exit Activity

Institutions that initiated new positions or completely exited SYRE in Q3 2025

New Positions: 18
New Value: $27.0M
Exited Positions: 14
Exited Value: $18.3M

New Positions

Institution	Position Value
TCG Crossover Management, LLC Venture Capital	$18.4M 1.1M shares
Parkman Healthcare Partners LLC Hedge Fund•Long/Short	$3.4M 200.8K shares
DIMENSIONAL FUND ADVISORS LP Long Only Manager	$1.4M 84.2K shares
O Opaleye Management Inc. Hedge Fund•Long/Short	$1.1M 65.0K shares
DLD Asset Management, LP Hedge Fund•Multi-Strategy	$502.8K 30.0K shares
Optimize Financial Inc RIA/Wealth	$418.4K 25.0K shares
Susquehanna Portfolio Strategies, LLC Private Equity	$364.3K 21.7K shares
Q Quadrature Capital Ltd Institution	$324.8K 19.4K shares
V VIRGINIA RETIREMENT SYSTEMS ET AL Institution	$310.1K 18.5K shares
LOS ANGELES CAPITAL MANAGEMENT & EQUITY RESEARCH INC Long Only Manager	$304.6K 18.2K shares

Exited Positions

Institution	Previous Position
A ADAGE CAPITAL PARTNERS GP LLC Institution	$9.1M 610.2K shares
Deep Track Capital, LP Hedge Fund•Long/Short	$3.3M 219.0K shares
C Capitolis Liquid Global Markets LLC Private Equity	$2.7M 183.0K shares
Foresite Capital Management VI LLC Venture Capital	$1.0M 70.0K shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$895.4K 59.8K shares
RENAISSANCE TECHNOLOGIES LLC Hedge Fund•Quant	$463.1K 30.9K shares
N NATIXIS Institution	$354.9K 20.0K shares
ING INVESTMENT MANAGEMENT LLC Insurance Manager	$203.4K 13.6K shares
M Man Group plc Institution	$162.3K 10.8K shares
S Skopos Labs, Inc. RIA/Wealth	$7.8K 520.0 shares

Options Activity

Institutions with the largest Call and Put options positions in SYRE as of Q3 2025

Call Positions: 1
Call Value: $1.4M
Put Positions: 1
Put Value: $838.0K

Call Positions

Institution	Position Value
Caption Management, LLC Hedge Fund•Long/Short	$1.4M 852.0 contracts

Put Positions

Institution	Position Value
Caption Management, LLC Hedge Fund•Long/Short	$838.0K 500.0 contracts

Most Committed Institutions

Institutions with SYRE as the highest % of their portfolio as of Q3 2025

Institution	Key People	Portfolio Weight	Ownership	Owned Since	Total AUM (Long)
Fairmount Funds Management LLC Hedge Fund•Sector	Peter Evan Harwin Managing Partner	6.06% $67.3M	6.65% 4.0M shares	Q4 2023 Held for 1y 11m	$1.1B
VR Adviser, LLC Venture Capital	Jessica Tong Baron CFO	2.53% $45.0M	4.45% 2.7M shares	Q4 2023 Held for 1y 11m	$1.8B
Affinity Asset Advisors, LLC Hedge Fund•Long/Short	Jonathan Bo-Shing Chu Founder	2.42% $23.8M	2.35% 1.4M shares	Q4 2023 Held for 1y 11m	$983.0M
T TANG CAPITAL MANAGEMENT LLC Institution	-	2.11% $53.6M	5.30% 3.2M shares	Q1 2025 Held for 8 months	$2.5B
B B Group, Inc. Institution	-	1.94% $1.7M	0.17% 100.0K shares	Q4 2024 Held for 11 months	$86.6M
B BRAIDWELL LP Hedge Fund•Multi-Strategy	Brian James Kreiter CEO	1.75% $43.2M	4.27% 2.6M shares	Q4 2023 Held for 1y 11m	$2.5B
COMMODORE CAPITAL LP Hedge Fund•Long/Short	Michael Jonathan Kramarz Managing Partner	1.63% $33.3M	3.29% 2.0M shares	Q4 2023 Held for 1y 11m	$2.0B
TCG Crossover Management, LLC Venture Capital	Chen Ming Yu Managing Partner	0.92% $18.4M	1.82% 1.1M shares	Q3 2025 Held for 2 months	$2.0B
HighVista Strategies LLC Fund of Funds	Richard P Vishton CFO	0.87% $3.6M	0.36% 215.7K shares	Q4 2023 Held for 1y 11m	$413.3M
RTW INVESTMENTS, LLC Hedge Fund•Sector	Peter M Fong President	0.75% $60.7M	6.00% 3.6M shares	Q4 2023 Held for 1y 11m	$8.1B

Hedge Fund Spotlight

Discover hedge funds investing in SYRE

Opaleye Management Inc.

Hedge Fund • Long/Short

Portfolio ManagerJames Aaron Silverman

Portfolio Value: $702.7M
Positions: 42
Last Reported: Q3 2025

Sector Allocation

Position in Spyre Therapeutics, Inc.

Market Value: $1.1M
Shares Held: 65.0K
Portfolio Weight: 0.16%
Owned Since: 2025-Q3

Top Holding	Sector	Market Value	Weight
1 HROW Harrow HROW	Medical - Pharmaceuticals Healthcare	$188.1M	26.77%
2 Eton Pharmaceuticals, Inc. ETON	Biotechnology Healthcare	$62.1M	8.84%
3 Liquidia Corporation LQDA	Biotechnology Healthcare	$59.5M	8.46%

View full profile

Spyre Therapeutics, Inc.

Overview

All Institutions

Hedge Funds

Ownership Breakdown

Biggest Investors

Net Capital Flow

Biggest Buyers

Biggest Sellers

Entry and Exit Activity

New Positions

Exited Positions

Options Activity

Call Positions

Put Positions

Most Committed Institutions

Hedge Fund Spotlight

Position in Spyre Therapeutics, Inc.

Cookie Preferences