Tenaya Therapeutics, Inc.

TNYA • NASDAQ

Tenaya Therapeutics, Inc. is a biotechnology company in the healthcare sector on NASDAQ, led by Faraz Ali, with a market cap of $141.5M. As of Q3 2025, 21% of shares are held by 88 institutional investors, with Column Group LLC as the largest holder at 5.77%.

CEOFaraz Ali

Market Cap$141.5M

Biotechnology

Healthcare

Employees140.0

Websitetenayatherapeutics.com

Country

United States of America

Overview

Overview of institutional ownership in TNYA as of Q3 2025 with a market cap of $264.0M

All Institutions

Institutions: 88
Value Held: $55.1M
Shares Held: 34.2M
Avg Position: $625.8K
Median Position: $53.4K

Hedge Funds

Hedge Funds: 11
Value Held: $14.8M
Shares Held: 9.1M
Avg Position: $1.3M
Median Position: $586.4K

Ownership Breakdown

Institutional (non-HF)

15.26%

$40.3M

Hedge Funds

5.6%

$14.8M

Retail & Other

79.14%

$208.9M

Based on market cap of $264.0M as of Q3 2025. Institutional (non-HF) excludes hedge funds to avoid double counting.

Biggest Investors

Institutions with the largest positions in TNYA as of Q3 2025

Institution	Key People	Position Value	Ownership	Owned Since	Total AUM (Long)
C Column Group LLC Institution	-	$14.9M 18.35% of portfolio	5.77% 9.4M shares	Q3 2021 Held for 4y 2m	$81.0M
VANGUARD GROUP INC Institution	Salim Ramji CEO	$8.2M 0.00% of portfolio	3.11% 5.1M shares	Q3 2021 Held for 4y 2m	$6.69T
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	Dan Michael Berkovitz Chairman	$7.3M 0.01% of portfolio	2.76% 4.5M shares	Q2 2022 Held for 3y 5m	$121.98B
B BlackRock, Inc. Institution	-	$3.8M 0.00% of portfolio	1.43% 2.3M shares	Q3 2021 Held for 4y 2m	$5.67T
RENAISSANCE TECHNOLOGIES LLC Hedge Fund•Quant	Peter Fitzhugh Brown CEO	$2.7M 0.00% of portfolio	1.03% 1.7M shares	Q3 2022 Held for 3y 2m	$75.8B
GEODE CAPITAL MANAGEMENT LLC ETF Provider	David Kenneth Lane CEO	$1.9M 0.00% of portfolio	0.72% 1.2M shares	Q3 2021 Held for 4y 2m	$1.57T
E Euclidean Capital LLC Institution	-	$1.6M 0.69% of portfolio	0.62% 1.0M shares	Q3 2021 Held for 4y 2m	$238.0M
Alphabet Inc. Institution	Sundar Pichai CEO	$1.5M 0.06% of portfolio	0.56% 915.7K shares	Q3 2021 Held for 4y 2m	$2.4B
TWO SIGMA INVESTMENTS LLC Hedge Fund•Multi-Strategy	Scott David Hoffman CEO	$1.5M 0.00% of portfolio	0.56% 910.6K shares	Q3 2022 Held for 3y 2m	$62.0B
S Standard Life Aberdeen plc Institution	-	$973.1K 0.00% of portfolio	0.37% 600.7K shares	Q3 2024 Held for 1y 2m	$63.2B

Net Capital Flow

Institutional buying and selling activity for TNYA in Q3 2025

Traded: +$5.9M
Buyers: 37
Sellers: 45
Total Bought: +$11.9M
Total Sold: −$6.0M
Avg Position: $519.5K

Biggest Buyers

Institution	Net Bought	Current Position
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	+$6.2M +3.8M shares	$7.3M 4.5M shares
Schonfeld Strategic Advisors LLC Hedge Fund•Multi-Strategy	+$754.8K +466.0K shares	$754.8K 466.0K shares
GSA CAPITAL PARTNERS LLP Hedge Fund•Quant	+$748.1K +461.8K shares	$748.1K 461.8K shares
TWO SIGMA INVESTMENTS LLC Hedge Fund•Multi-Strategy	+$706.0K +435.8K shares	$1.5M 910.6K shares
R Raiffeisen Bank International AG Institution	+$567.0K +350.0K shares	$567.0K 350.0K shares
DIADEMA PARTNERS LP Hedge Fund•Long/Short	+$511.1K +315.5K shares	$511.1K 315.5K shares
VANGUARD GROUP INC Institution	+$501.4K +309.5K shares	$8.2M 5.1M shares
STATE STREET CORP Institution	+$382.3K +236.0K shares	$722.2K 445.8K shares
NORTHERN TRUST CORP Institution	+$178.3K +110.0K shares	$388.0K 239.5K shares
S SIMPLEX TRADING, LLC Institution	+$167.5K +103.4K shares	$181.3K 111.9K shares

Biggest Sellers

Institution	Net Sold	Current Position
AQR CAPITAL MANAGEMENT LLC Hedge Fund•Multi-Strategy	−$2.6M −1.6M shares	$258.6K 159.6K shares
B BlackRock, Inc. Institution	−$657.1K −405.6K shares	$3.8M 2.3M shares
S Squarepoint Ops LLC Hedge Fund•Quant	−$563.0K −347.6K shares	$58.7K 36.3K shares
J JANE STREET GROUP, LLC Institution	−$356.1K −219.8K shares	$253.1K 156.3K shares
RENAISSANCE TECHNOLOGIES LLC Hedge Fund•Quant	−$268.4K −165.7K shares	$2.7M 1.7M shares
IEQ CAPITAL, LLC RIA/Wealth	−$258.8K −159.8K shares	$38.4K 23.7K shares
Marshall Wace LLP Institution	−$211.9K −130.8K shares	$28.0K 17.3K shares
V Virtu Financial LLC Institution	−$202.9K −125.2K shares	$71.7K 44.2K shares
CWM, LLC RIA/Wealth	−$122.2K −75.4K shares	$23.7K 14.6K shares
GEODE CAPITAL MANAGEMENT LLC ETF Provider	−$89.2K −55.1K shares	$1.9M 1.2M shares

Entry and Exit Activity

Institutions that initiated new positions or completely exited TNYA in Q3 2025

New Positions: 12
New Value: $1.6M
Exited Positions: 18
Exited Value: $296.3K

New Positions

Institution	Position Value
R Raiffeisen Bank International AG Institution	$567.0K 350.0K shares
DIADEMA PARTNERS LP Hedge Fund•Long/Short	$511.1K 315.5K shares
P Persistent Asset Partners Ltd Institution	$117.4K 72.5K shares
LEUCADIA NATIONAL CORP Institution	$99.3K 61.3K shares
Cetera Investment Advisers RIA/Wealth	$83.3K 51.4K shares
Q Quadrature Capital Ltd Institution	$80.2K 49.0K shares
T TWO SIGMA SECURITIES, LLC Institution	$32.4K 20.0K shares
Parkwoods Wealth Partners, LLC RIA/Wealth	$24.3K 15.0K shares
Peregrine Asset Advisers, Inc. RIA/Wealth	$20.0K 12.4K shares
Aptus Capital Advisors, LLC ETF Provider	$19.5K 12.1K shares

Exited Positions

Institution	Previous Position
HPM Partners LLC RIA/Wealth	$67.4K 110.3K shares
Savant Capital, LLC RIA/Wealth	$52.1K 85.3K shares
Jain Global LLC Hedge Fund•Multi-Strategy	$48.8K 79.9K shares
WEALTH ENHANCEMENT ADVISORY SERVICES, LLC RIA/Wealth	$23.7K 38.7K shares
H HRT FINANCIAL LLC Institution	$21.0K 34.3K shares
Pallas Capital Advisors LLC RIA/Wealth	$16.4K 26.8K shares
T Tower Research Capital LLC Institution	$15.6K 25.6K shares
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$14.7K 24.1K shares
MERCER GLOBAL ADVISORS INC /ADV RIA/Wealth	$10.2K 16.7K shares
CAPTRUST FINANCIAL ADVISORS RIA/Wealth	$8.3K 13.6K shares

Options Activity

Institutions with the largest Call and Put options positions in TNYA as of Q3 2025

Call Positions: 3
Call Value: $506.9K
Put Positions: 2
Put Value: $99.0K

Call Positions

Institution	Position Value
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$244.3K 1.5K contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$167.5K 1.0K contracts
J JANE STREET GROUP, LLC Institution	$95.1K 587.0 contracts

Put Positions

Institution	Position Value
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$79.5K 491.0 contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$19.4K 120.0 contracts

Most Committed Institutions

Institutions with TNYA as the highest % of their portfolio as of Q3 2025

Institution	Key People	Portfolio Weight	Ownership	Owned Since	Total AUM (Long)
C Column Group LLC Institution	-	18.35% $14.9M	5.77% 9.4M shares	Q3 2021 Held for 4y 2m	$81.0M
E Euclidean Capital LLC Institution	-	0.69% $1.6M	0.62% 1.0M shares	Q3 2021 Held for 4y 2m	$238.0M
StepStone Group LP Fund of Funds	Scott William Hart CEO	0.39% $748.7K	0.28% 462.2K shares	Q3 2021 Held for 4y 2m	$191.8M
DIADEMA PARTNERS LP Hedge Fund•Long/Short	Timothy Beau Bassett CIO	0.36% $511.1K	0.19% 315.5K shares	Q3 2025 Held for 2 months	$143.3M
P Persistent Asset Partners Ltd Institution	-	0.09% $117.4K	0.04% 72.5K shares	Q3 2025 Held for 2 months	$137.1M
T Trustees of Columbia University in the City of New York RIA/Wealth	Michael Winston Bain CCO	0.07% $472.8K	0.18% 291.8K shares	Q4 2024 Held for 11 months	$655.3M
GSA CAPITAL PARTNERS LLP Hedge Fund•Quant	David Khabie-Zeitoune CEO	0.07% $748.1K	0.28% 461.8K shares	Q3 2025 Held for 2 months	$1.1B
Alphabet Inc. Institution	Sundar Pichai CEO	0.06% $1.5M	0.56% 915.7K shares	Q3 2021 Held for 4y 2m	$2.4B
Casdin Capital, LLC Hedge Fund•Sector	Eli D Casdin Managing Partner	0.05% $586.4K	0.22% 362.0K shares	Q3 2021 Held for 4y 2m	$1.2B
ATTICUS WEALTH MANAGEMENT, LLC RIA/Wealth	Enoch Carter Morris CCO	0.02% $72.7K	0.03% 44.9K shares	Q2 2023 Held for 2y 5m	$396.2M

Hedge Fund Spotlight

Discover hedge funds investing in TNYA

Scientech Research LLC

Hedge Fund • Market Neutral

Portfolio ManagerRui Wei

Portfolio Value: $283.5M
Positions: 542
Last Reported: Q3 2025

Sector Allocation

Position in Tenaya Therapeutics, Inc.

Market Value: $26.6K
Shares Held: 16.4K
Portfolio Weight: 0.01%
Owned Since: 2025-Q1

Top Holding	Sector	Market Value	Weight
1 Microsoft MSFT	Software - Infrastructure Technology	$2.2M	0.77%
2 Nvidia NVDA	Semiconductors Technology	$2.0M	0.70%
3 Applovin Corporation APP	Software - Application Technology	$2.0M	0.69%