Edgewise Therapeutics, Inc.

EWTX • NASDAQ

Edgewise Therapeutics, Inc. is a biotechnology company in the healthcare sector on NASDAQ, led by Kevin Koch, with a market cap of $2.5B. As of Q3 2025, 106% of shares are held by 172 institutional investors, with ORBIMED ADVISORS LLC as the largest holder at 14.73%.

CEOKevin Koch

Market Cap$2.5B

Biotechnology

Healthcare

Employees92.0

Websiteedgewisetx.com

Country

United States of America

Overview

Overview of institutional ownership in EWTX as of Q3 2025 with a market cap of $1.7B

All Institutions

Institutions: 172
Value Held: $1.8B
Shares Held: 112.0M
Avg Position: $10.6M
Median Position: $726.0K

Hedge Funds

Hedge Funds: 34
Value Held: $1.0B
Shares Held: 62.3M
Avg Position: $29.7M
Median Position: $3.9M

Ownership Breakdown

Institutional (non-HF)

47.15%

$805.7M

Hedge Funds

59.13%

$1.0B

Retail & Other

Based on market cap of $1.7B as of Q3 2025. Institutional (non-HF) excludes hedge funds to avoid double counting.

Biggest Investors

Institutions with the largest positions in EWTX as of Q3 2025

Institution	Key People	Position Value	Ownership	Owned Since	Total AUM (Long)
ORBIMED ADVISORS LLC Hedge Fund•Sector	Sam Block Iii CFO	$251.7M 6.11% of portfolio	14.73% 15.5M shares	Q1 2021 Held for 4y 8m	$4.1B
RA CAPITAL MANAGEMENT, LLC Hedge Fund•Long/Short	Michael Saulnier CFO	$169.1M 2.10% of portfolio	9.90% 10.4M shares	Q1 2024 Held for 1y 8m	$8.1B
B BAKER BROS. ADVISORS LP Hedge Fund•Sector	Scott Lawrence Lessing President	$118.5M 1.10% of portfolio	6.94% 7.3M shares	Q1 2021 Held for 4y 8m	$10.8B
B BlackRock, Inc. Institution	-	$103.0M 0.00% of portfolio	6.03% 6.4M shares	Q1 2021 Held for 4y 8m	$5.67T
Paradigm Biocapital Advisors LP Hedge Fund•Long/Short	Dr. Senai Nmn Asefaw CIO	$100.1M 2.96% of portfolio	5.86% 6.2M shares	Q1 2024 Held for 1y 8m	$3.4B
N Novo A/S Institution	-	$86.8M 5.70% of portfolio	5.08% 5.4M shares	Q1 2021 Held for 4y 8m	$1.5B
B BRAIDWELL LP Hedge Fund•Multi-Strategy	Brian James Kreiter CEO	$84.5M 3.42% of portfolio	4.95% 5.2M shares	Q3 2024 Held for 1y 2m	$2.5B
HENDERSON GROUP PLC Institution	Ali Dibadj CEO	$80.8M 0.04% of portfolio	4.73% 5.0M shares	Q1 2021 Held for 4y 8m	$218.74B
VANGUARD GROUP INC Institution	Salim Ramji CEO	$77.9M 0.00% of portfolio	4.56% 4.8M shares	Q1 2021 Held for 4y 8m	$6.69T
C Cormorant Asset Management, LLC Hedge Fund•Long/Short	Bihua Chen CEO	$65.0M 5.07% of portfolio	3.81% 4.0M shares	Q1 2021 Held for 4y 8m	$1.3B

Net Capital Flow

Institutional buying and selling activity for EWTX in Q3 2025

Traded: −$95.9M
Buyers: 77
Sellers: 82
Total Bought: +$63.1M
Total Sold: −$159.0M
Avg Position: $9.4M

Biggest Buyers

Institution	Net Bought	Current Position
S Siren, L.L.C. Institution	+$12.0M +736.8K shares	$63.2M 3.9M shares
RA CAPITAL MANAGEMENT, LLC Hedge Fund•Long/Short	+$8.5M +525.8K shares	$169.1M 10.4M shares
Integral Health Asset Management, LLC Hedge Fund•Sector	+$8.1M +500.0K shares	$24.3M 1.5M shares
A AMERICAN CENTURY COMPANIES INC Institution	+$5.1M +312.3K shares	$17.8M 1.1M shares
S Standard Life Aberdeen plc Institution	+$2.9M +176.6K shares	$10.1M 619.9K shares
MORGAN STANLEY RIA/Wealth	+$2.3M +142.0K shares	$14.1M 869.7K shares
HighVista Strategies LLC Fund of Funds	+$2.2M +138.4K shares	$3.4M 208.1K shares
DIMENSIONAL FUND ADVISORS LP Long Only Manager	+$2.2M +134.2K shares	$19.2M 1.2M shares
DRIEHAUS CAPITAL MANAGEMENT LLC Hedge Fund•Event Driven	+$2.1M +126.5K shares	$36.1M 2.2M shares
Eversept Partners, LLC Hedge Fund•Long/Short	+$1.8M +109.5K shares	$8.1M 502.2K shares

Biggest Sellers

Institution	Net Sold	Current Position
DEERFIELD MANAGEMENT CO /NY Hedge Fund•Long/Short	−$21.1M −1.3M shares	$12.4M 765.7K shares
Woodline Partners LP Hedge Fund•Long/Short	−$14.2M −872.7K shares	$3.6M 224.2K shares
PERCEPTIVE ADVISORS LLC Hedge Fund•Long/Short	−$13.7M −844.1K shares	$61.6M 3.8M shares
Polar Capital Holdings Plc Long Only Manager	−$12.8M −975.0K shares	Sold Off 0 shares
Artisan Partners Limited Partnership Long Only Manager	−$10.7M −660.9K shares	$11.6M 718.2K shares
HENDERSON GROUP PLC Institution	−$8.5M −524.0K shares	$80.8M 5.0M shares
Foresite Capital Management VI LLC Venture Capital	−$7.7M −585.0K shares	Sold Off 0 shares
B BlackRock, Inc. Institution	−$7.0M −429.6K shares	$103.0M 6.4M shares
First Light Asset Management, LLC Hedge Fund•Sector	−$4.9M −299.0K shares	$23.0M 1.4M shares
FEDERATED INVESTORS INC /PA/ Long Only Manager	−$4.2M −257.2K shares	$961.1K 59.3K shares

Entry and Exit Activity

Institutions that initiated new positions or completely exited EWTX in Q3 2025

New Positions: 7
New Value: $60.0K
Exited Positions: 21
Exited Value: $32.6M

New Positions

Institution	Position Value
Steward Partners Investment Advisory, LLC RIA/Wealth	$37.4K 2.3K shares
KAYNE ANDERSON RUDNICK INVESTMENT MANAGEMENT LLC Long Only Manager	$10.1K 622.0 shares
O Optiver Holding B.V. Institution	$7.6K 468.0 shares
A Advisory Services Network, LLC RIA/Wealth	$2.5K 151.0 shares
Larson Financial Group LLC RIA/Wealth	$2.2K 135.0 shares
MONTAG A & ASSOCIATES INC RIA/Wealth	$260.0 16.0 shares
Hartland & Co., LLC RIA/Wealth	$65.0 4.0 shares

Exited Positions

Institution	Previous Position
Polar Capital Holdings Plc Long Only Manager	$12.8M 975.0K shares
Foresite Capital Management VI LLC Venture Capital	$7.7M 585.0K shares
VOLORIDGE INVESTMENT MANAGEMENT, LLC Hedge Fund•Multi-Strategy	$3.7M 284.6K shares
Walleye Trading Advisors, LLC Hedge Fund•Multi-Strategy	$1.1M 86.9K shares
T TWINBEECH CAPITAL LP Hedge Fund•Quant	$1.0M 78.3K shares
Soleus Capital Management, L.P. Hedge Fund•Long/Short	$1.0M 76.5K shares
X XTX Topco Ltd Institution	$796.3K 60.7K shares
UBS OCONNOR LLC Long Only Manager	$724.9K 55.3K shares
Verition Fund Management LLC Hedge Fund•Multi-Strategy	$577.7K 44.1K shares
TUDOR INVESTMENT CORP ET AL Hedge Fund•Multi-Strategy	$546.2K 41.7K shares

Options Activity

Institutions with the largest Call and Put options positions in EWTX as of Q3 2025

Call Positions: 6
Call Value: $3.7M
Put Positions: 3
Put Value: $2.0M

Call Positions

Institution	Position Value
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$1.2M 765.0 contracts
T Troluce Capital Advisors LLC Hedge Fund•Multi-Strategy	$892.1K 550.0 contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$747.7K 461.0 contracts
TUDOR INVESTMENT CORP ET AL Hedge Fund•Multi-Strategy	$627.7K 387.0 contracts
BOOTHBAY FUND MANAGEMENT, LLC Fund of Funds	$173.6K 107.0 contracts
Walleye Trading Advisors, LLC Hedge Fund•Multi-Strategy	- - contracts

Put Positions

Institution	Position Value
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$1.6M 1.0K contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$311.4K 192.0 contracts
Walleye Trading Advisors, LLC Hedge Fund•Multi-Strategy	- - contracts

Most Committed Institutions

Institutions with EWTX as the highest % of their portfolio as of Q3 2025

Institution	Key People	Portfolio Weight	Ownership	Owned Since	Total AUM (Long)
New Leaf Venture Partners, L.L.C. Venture Capital	Vijay Kiran Lathi Managing Partner	38.82% $16.7M	0.98% 1.0M shares	Q1 2021 Held for 4y 8m	$43.0M
ORBIMED ADVISORS LLC Hedge Fund•Sector	Sam Block Iii CFO	6.11% $251.7M	14.73% 15.5M shares	Q1 2021 Held for 4y 8m	$4.1B
N Novo A/S Institution	-	5.70% $86.8M	5.08% 5.4M shares	Q1 2021 Held for 4y 8m	$1.5B
C Cormorant Asset Management, LLC Hedge Fund•Long/Short	Bihua Chen CEO	5.07% $65.0M	3.81% 4.0M shares	Q1 2021 Held for 4y 8m	$1.3B
MPM Oncology Impact Management LP Institution	Christian Albrecht Wulf Von Schimmelmann Managing Partner	4.57% $27.9M	1.63% 1.7M shares	Q1 2024 Held for 1y 8m	$610.9M
B BRAIDWELL LP Hedge Fund•Multi-Strategy	Brian James Kreiter CEO	3.42% $84.5M	4.95% 5.2M shares	Q3 2024 Held for 1y 2m	$2.5B
Paradigm Biocapital Advisors LP Hedge Fund•Long/Short	Dr. Senai Nmn Asefaw CIO	2.96% $100.1M	5.86% 6.2M shares	Q1 2024 Held for 1y 8m	$3.4B
S Siren, L.L.C. Institution	-	2.65% $63.2M	3.70% 3.9M shares	Q3 2024 Held for 1y 2m	$2.4B
First Light Asset Management, LLC Hedge Fund•Sector	Mathew Paul Arens CEO	2.16% $23.0M	1.34% 1.4M shares	Q4 2024 Held for 11 months	$1.1B
RA CAPITAL MANAGEMENT, LLC Hedge Fund•Long/Short	Michael Saulnier CFO	2.10% $169.1M	9.90% 10.4M shares	Q1 2024 Held for 1y 8m	$8.1B

Hedge Fund Spotlight

Discover hedge funds investing in EWTX

RA CAPITAL MANAGEMENT, LLC

Hedge Fund • Long/Short

Portfolio ManagerMichael Saulnier

Portfolio Value: $8.1B
Positions: 66
Last Reported: Q3 2025

Sector Allocation

Position in Edgewise Therapeutics, Inc.

Market Value: $169.1M
Shares Held: 10.4M
Portfolio Weight: 2.10%
Owned Since: 2024-Q1

Top Holding	Sector	Market Value	Weight
1 ASND Ascendis Pharma ASND	Unknown Unknown	$2.0B	25.39%
2 Rhythm Pharmaceuticals, Inc. RYTM	Biotechnology Healthcare	$573.8M	7.13%
3 Vaxcyte, Inc. PCVX	Biotechnology Healthcare	$431.0M	5.35%

View full profile

Edgewise Therapeutics, Inc.

Overview

All Institutions

Hedge Funds

Ownership Breakdown

Biggest Investors

Net Capital Flow

Biggest Buyers

Biggest Sellers

Entry and Exit Activity

New Positions

Exited Positions

Options Activity

Call Positions

Put Positions

Most Committed Institutions

Hedge Fund Spotlight

Position in Edgewise Therapeutics, Inc.

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