Disc Medicine

IRON • NASDAQ

Disc Medicine is a biotechnology company in the healthcare sector on NASDAQ, with a market cap of $3.5B. As of Q3 2025, 98% of shares are held by 165 institutional investors, with FMR LLC as the largest holder at 14.2%.

Market Cap$3.5B

Biotechnology

Healthcare

Employees74.0

Websitediscmedicine.com

Country

United States of America

Overview

Overview of institutional ownership in IRON as of Q3 2025 with a market cap of $2.3B

All Institutions

Institutions: 165
Value Held: $2.3B
Shares Held: 34.2M
Avg Position: $13.7M
Median Position: $1.2M

Hedge Funds

Hedge Funds: 34
Value Held: $664.2M
Shares Held: 10.1M
Avg Position: $19.5M
Median Position: $13.8M

Ownership Breakdown

Institutional (non-HF)

69.4%

$1.6B

Hedge Funds

28.91%

$664.2M

Retail & Other

1.69%

$38.8M

Based on market cap of $2.3B as of Q3 2025. Institutional (non-HF) excludes hedge funds to avoid double counting.

Biggest Investors

Institutions with the largest positions in IRON as of Q3 2025

Institution	Key People	Position Value	Ownership	Owned Since	Total AUM (Long)
FMR LLC Institution	-	$326.1M 0.02% of portfolio	14.20% 4.9M shares	Q4 2022 Held for 2y 11m	$1.92T
A Atlas Venture Life Science Advisors, LLC Institution	-	$141.6M 18.81% of portfolio	6.16% 2.1M shares	Q4 2022 Held for 2y 11m	$752.6M
B BlackRock, Inc. Institution	-	$133.4M 0.00% of portfolio	5.81% 2.0M shares	Q4 2022 Held for 2y 11m	$5.67T
RA CAPITAL MANAGEMENT, LLC Hedge Fund•Long/Short	Michael Saulnier CFO	$104.2M 1.29% of portfolio	4.54% 1.6M shares	Q1 2025 Held for 8 months	$8.1B
VANGUARD GROUP INC Institution	Salim Ramji CEO	$95.7M 0.00% of portfolio	4.17% 1.4M shares	Q4 2022 Held for 2y 11m	$6.69T
Frazier Life Sciences Management, L.P. Venture Capital	James Newman Topper Managing Partner	$95.1M 2.85% of portfolio	4.14% 1.4M shares	Q2 2023 Held for 2y 5m	$3.3B
ORBIMED ADVISORS LLC Hedge Fund•Sector	Sam Block Iii CFO	$93.5M 2.27% of portfolio	4.07% 1.4M shares	Q4 2022 Held for 2y 11m	$4.1B
WELLINGTON MANAGEMENT CO LLP Long Only Manager	Jean Marie Hynes CEO	$93.2M 0.02% of portfolio	4.06% 1.4M shares	Q2 2023 Held for 2y 5m	$571.21B
PRICE T ROWE ASSOCIATES INC /MD/ Long Only Manager	Robert W Sharps President	$87.7M 0.01% of portfolio	3.82% 1.3M shares	Q2 2023 Held for 2y 5m	$912.31B
STATE STREET CORP Institution	Ronald P. O'Hanley CEO	$69.1M 0.00% of portfolio	3.01% 1.0M shares	Q4 2022 Held for 2y 11m	$2.88T

Net Capital Flow

Institutional buying and selling activity for IRON in Q3 2025

Traded: +$24.8M
Buyers: 88
Sellers: 52
Total Bought: +$311.6M
Total Sold: −$286.8M
Avg Position: $12.8M

Biggest Buyers

Institution	Net Bought	Current Position
FMR LLC Institution	+$111.6M +1.7M shares	$326.1M 4.9M shares
Vestal Point Capital, LP Hedge Fund•Long/Short	+$23.8M +360.0K shares	$33.0M 500.0K shares
BALYASNY ASSET MANAGEMENT LLC Hedge Fund•Multi-Strategy	+$22.3M +338.1K shares	$22.3M 338.1K shares
GOLDMAN SACHS GROUP INC Institution	+$20.0M +303.2K shares	$35.0M 529.1K shares
First Light Asset Management, LLC Hedge Fund•Sector	+$15.3M +231.2K shares	$15.3M 231.2K shares
Catalio Capital Management, LP Venture Capital	+$12.3M +185.9K shares	$14.3M 216.5K shares
TimesSquare Capital Management, LLC Long Only Manager	+$12.0M +182.2K shares	$12.0M 182.2K shares
Checkpoint Capital L.P. Hedge Fund•Sector	+$10.9M +165.0K shares	$28.4M 430.0K shares
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	+$9.2M +139.4K shares	$10.6M 161.0K shares
STATE STREET CORP Institution	+$7.7M +115.8K shares	$69.1M 1.0M shares

Biggest Sellers

Institution	Net Sold	Current Position
HENDERSON GROUP PLC Institution	−$78.8M −1.2M shares	$23.9M 361.7K shares
Paradigm Biocapital Advisors LP Hedge Fund•Long/Short	−$63.7M −963.3K shares	$16.4M 247.7K shares
B Bain Capital Life Sciences Investors, LLC Institution	−$30.9M −583.5K shares	Sold Off 0 shares
Logos Global Management LP Hedge Fund•Long/Short	−$16.5M −250.0K shares	$29.7M 450.0K shares
A Atlas Venture Life Science Advisors, LLC Institution	−$16.0M −241.8K shares	$141.6M 2.1M shares
Frazier Life Sciences Management, L.P. Venture Capital	−$14.3M −216.3K shares	$95.1M 1.4M shares
PRICE T ROWE ASSOCIATES INC /MD/ Long Only Manager	−$12.5M −189.2K shares	$87.7M 1.3M shares
S Siren, L.L.C. Institution	−$12.3M −186.0K shares	$60.4M 913.4K shares
JPMORGAN CHASE & CO Institution	−$6.0M −90.7K shares	$49.8M 752.9K shares
S Saturn V Capital Management LLC Hedge Fund•Sector	−$3.6M −55.2K shares	$22.5M 340.9K shares

Entry and Exit Activity

Institutions that initiated new positions or completely exited IRON in Q3 2025

New Positions: 11
New Value: $30.6M
Exited Positions: 9
Exited Value: $39.1M

New Positions

Institution	Position Value
First Light Asset Management, LLC Hedge Fund•Sector	$15.3M 231.2K shares
TimesSquare Capital Management, LLC Long Only Manager	$12.0M 182.2K shares
A AMERICAN CENTURY COMPANIES INC Institution	$1.8M 27.9K shares
KENNEDY CAPITAL MANAGEMENT, INC. Long Only Manager	$596.6K 9.0K shares
C Campbell & CO Investment Adviser LLC Hedge Fund•Quant Macro	$349.6K 5.3K shares
B Bryce Point Capital, LLC Hedge Fund•Market Neutral	$258.5K 3.9K shares
Susquehanna Portfolio Strategies, LLC Private Equity	$246.7K 3.7K shares
SRS Capital Advisors, Inc. RIA/Wealth	$13.6K 206.0 shares
O Optiver Holding B.V. Institution	$12.8K 194.0 shares
B Bare Financial Services, Inc Institution	$595.0 9.0 shares

Exited Positions

Institution	Previous Position
B Bain Capital Life Sciences Investors, LLC Institution	$30.9M 583.5K shares
ExodusPoint Capital Management, LP Hedge Fund•Multi-Strategy	$3.1M 57.9K shares
B Bollard Group LLC Family Office	$1.6M 30.6K shares
VOLORIDGE INVESTMENT MANAGEMENT, LLC Hedge Fund•Multi-Strategy	$1.0M 19.7K shares
Harvest Investment Services, LLC RIA/Wealth	$758.2K 14.3K shares
UBS OCONNOR LLC Long Only Manager	$652.3K 12.3K shares
FIRST TRUST ADVISORS LP ETF Provider	$542.6K 10.2K shares
HighVista Strategies LLC Fund of Funds	$356.6K 6.7K shares
MEEDER ASSET MANAGEMENT INC Long Only Manager	$118.8K 2.2K shares

Options Activity

Institutions with the largest Call and Put options positions in IRON as of Q3 2025

Call Positions: 5
Call Value: $3.1M
Put Positions: 3
Put Value: $753.3K

Call Positions

Institution	Position Value
D D. E. Shaw & Co., Inc. Institution	$1.6M 249.0 contracts
N NOMURA HOLDINGS INC Institution	$892.1K 135.0 contracts
Caption Management, LLC Hedge Fund•Long/Short	$502.2K 76.0 contracts
Walleye Trading Advisors, LLC Hedge Fund•Multi-Strategy	$33.0K 5.0 contracts
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	- - contracts

Put Positions

Institution	Position Value
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$475.8K 72.0 contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$257.7K 39.0 contracts
Walleye Trading Advisors, LLC Hedge Fund•Multi-Strategy	$19.8K 3.0 contracts

Most Committed Institutions

Institutions with IRON as the highest % of their portfolio as of Q3 2025

Institution	Key People	Portfolio Weight	Ownership	Owned Since	Total AUM (Long)
A Atlas Venture Life Science Advisors, LLC Institution	-	18.81% $141.6M	6.16% 2.1M shares	Q4 2022 Held for 2y 11m	$752.6M
Foresite Capital Management V, LLC Venture Capital	James Bruce Tananbaum CEO	18.17% $19.8M	0.86% 299.1K shares	Q4 2022 Held for 2y 11m	$108.7M
Checkpoint Capital L.P. Hedge Fund•Sector	Tony Michael Berta CFO	15.13% $28.4M	1.24% 430.0K shares	Q3 2024 Held for 1y 2m	$187.8M
S Saturn V Capital Management LLC Hedge Fund•Sector	Xiaoying (Nmn) Tian Partner	4.94% $22.5M	0.98% 340.9K shares	Q4 2023 Held for 1y 11m	$456.0M
Sio Capital Management, LLC Hedge Fund•Long/Short	Judah Zvi Drillick CEO	4.76% $18.8M	0.82% 284.8K shares	Q2 2024 Held for 1y 5m	$395.2M
L Lion Point Capital, LP Hedge Fund•Event Driven	Carl Didric Marcus Cederholm CIO	3.98% $700.4K	0.03% 10.6K shares	Q3 2024 Held for 1y 2m	$17.6M
F First Turn Management, LLC Hedge Fund•Long/Short	Lisa Gable Wheatley Managing Partner	3.95% $26.3M	1.14% 397.7K shares	Q2 2025 Held for 5 months	$666.0M
Logos Global Management LP Hedge Fund•Long/Short	Graham Gordon Walmsley Managing Partner	3.01% $29.7M	1.29% 450.0K shares	Q2 2024 Held for 1y 5m	$987.5M
Frazier Life Sciences Management, L.P. Venture Capital	James Newman Topper Managing Partner	2.85% $95.1M	4.14% 1.4M shares	Q2 2023 Held for 2y 5m	$3.3B
P Palo Alto Investors, LLC Hedge Fund•Long/Short	Angela Elizabeth Nguyen-Dinh CCO	2.74% $14.8M	0.65% 224.3K shares	Q2 2025 Held for 5 months	$540.4M

Hedge Fund Spotlight

Discover hedge funds investing in IRON

ARMISTICE CAPITAL, LLC

Hedge Fund • Long/Short

Portfolio ManagerSteven Joseph Boyd

Portfolio Value: $3.2B
Positions: 313
Last Reported: Q3 2025

Sector Allocation

Position in Disc Medicine

Market Value: $28.8M
Shares Held: 436.0K
Portfolio Weight: 0.91%
Owned Since: 2024-Q3

Top Holding	Sector	Market Value	Weight
1 PTC Therapeutics PTCT	Biotechnology Healthcare	$201.1M	6.38%
2 Travere Therapeutics, Inc. TVTX	Biotechnology Healthcare	$160.7M	5.10%
3 Supernus Pharmaceuticals SUPN	Drug Manufacturers - Specialty & Generic Healthcare	$135.5M	4.30%