Praxis Precision Medicines, Inc.

PRAX • NASDAQ

Praxis Precision Medicines, Inc. is a biotechnology company in the healthcare sector on NASDAQ, led by Timothy E. Kelly, with a market cap of $6.7B. As of Q3 2025, 117% of shares are held by 150 institutional investors, with HENDERSON GROUP PLC as the largest holder at 13.13%.

Chief Executive OfficerTimothy E. Kelly

Market Cap$6.7B

Biotechnology

Healthcare

Employees82.0

Websitepraxismedicines.com

Country

United States of America

Overview

Overview of institutional ownership in PRAX as of Q3 2025 with a market cap of $1.1B

All Institutions

Institutions: 150
Value Held: $1.3B
Shares Held: 24.7M
Avg Position: $8.7M
Median Position: $1.1M

Hedge Funds

Hedge Funds: 28
Value Held: $442.2M
Shares Held: 8.3M
Avg Position: $15.8M
Median Position: $3.6M

Ownership Breakdown

Institutional (non-HF)

77.54%

$865.1M

Hedge Funds

39.64%

$442.2M

Retail & Other

Based on market cap of $1.1B as of Q3 2025. Institutional (non-HF) excludes hedge funds to avoid double counting.

Biggest Investors

Institutions with the largest positions in PRAX as of Q3 2025

Institution	Key People	Position Value	Ownership	Owned Since	Total AUM (Long)
HENDERSON GROUP PLC Institution	Ali Dibadj CEO	$146.5M 0.07% of portfolio	13.13% 2.8M shares	Q1 2024 Held for 1y 8m	$218.74B
A ADAGE CAPITAL PARTNERS GP LLC Institution	-	$125.8M 0.20% of portfolio	11.28% 2.4M shares	Q4 2020 Held for 4y 11m	$63.0B
B BlackRock, Inc. Institution	-	$95.5M 0.00% of portfolio	8.56% 1.8M shares	Q4 2020 Held for 4y 11m	$5.67T
PERCEPTIVE ADVISORS LLC Hedge Fund•Long/Short	Joseph Eric Edelman CEO	$82.9M 2.40% of portfolio	7.43% 1.6M shares	Q1 2024 Held for 1y 8m	$3.5B
Point72 Asset Management, L.P. Hedge Fund•Multi-Strategy	Steven Alan Cohen CEO	$79.3M 0.18% of portfolio	7.11% 1.5M shares	Q4 2020 Held for 4y 11m	$43.2B
VANGUARD GROUP INC Institution	Salim Ramji CEO	$67.2M 0.00% of portfolio	6.02% 1.3M shares	Q4 2020 Held for 4y 11m	$6.69T
PRICE T ROWE ASSOCIATES INC /MD/ Long Only Manager	Robert W Sharps President	$53.2M 0.01% of portfolio	4.77% 1.0M shares	Q1 2024 Held for 1y 8m	$912.31B
C Cormorant Asset Management, LLC Hedge Fund•Long/Short	Bihua Chen CEO	$53.0M 4.13% of portfolio	4.75% 1.0M shares	Q2 2023 Held for 2y 5m	$1.3B
STATE STREET CORP Institution	Ronald P. O'Hanley CEO	$48.1M 0.00% of portfolio	4.31% 907.1K shares	Q4 2020 Held for 4y 11m	$2.88T
Soleus Capital Management, L.P. Hedge Fund•Long/Short	Guy Bezalel Levy CIO	$45.5M 2.49% of portfolio	4.08% 859.2K shares	Q2 2023 Held for 2y 5m	$1.8B

Net Capital Flow

Institutional buying and selling activity for PRAX in Q3 2025

Traded: +$39.2M
Buyers: 86
Sellers: 64
Total Bought: +$242.4M
Total Sold: −$203.2M
Avg Position: $7.7M

Biggest Buyers

Institution	Net Bought	Current Position
PERCEPTIVE ADVISORS LLC Hedge Fund•Long/Short	+$43.0M +811.6K shares	$82.9M 1.6M shares
Point72 Asset Management, L.P. Hedge Fund•Multi-Strategy	+$28.7M +541.9K shares	$79.3M 1.5M shares
A ADAGE CAPITAL PARTNERS GP LLC Institution	+$21.2M +399.5K shares	$125.8M 2.4M shares
Woodline Partners LP Hedge Fund•Long/Short	+$19.7M +371.7K shares	$22.1M 417.7K shares
GOLDMAN SACHS GROUP INC Institution	+$19.5M +367.0K shares	$31.4M 593.0K shares
HENDERSON GROUP PLC Institution	+$12.2M +230.5K shares	$146.5M 2.8M shares
B BlackRock, Inc. Institution	+$11.2M +211.0K shares	$95.5M 1.8M shares
STATE STREET CORP Institution	+$11.1M +209.0K shares	$48.1M 907.1K shares
S Sofinnova Ventures Inc Venture Capital	+$8.3M +157.1K shares	$9.2M 172.8K shares
DEERFIELD MANAGEMENT CO /NY Hedge Fund•Long/Short	+$8.2M +153.9K shares	$44.6M 840.9K shares

Biggest Sellers

Institution	Net Sold	Current Position
C Cormorant Asset Management, LLC Hedge Fund•Long/Short	−$33.1M −625.0K shares	$53.0M 1.0M shares
MORGAN STANLEY RIA/Wealth	−$30.9M −582.8K shares	$34.1M 643.5K shares
PRICE T ROWE ASSOCIATES INC /MD/ Long Only Manager	−$24.9M −469.6K shares	$53.2M 1.0M shares
BALYASNY ASSET MANAGEMENT LLC Hedge Fund•Multi-Strategy	−$15.5M −369.3K shares	Sold Off 0 shares
Ikarian Capital, LLC Hedge Fund•Event Driven	−$13.2M −248.4K shares	$1.5M 28.6K shares
A Assenagon Asset Management S.A. Institution	−$10.3M −194.5K shares	$21.7M 409.8K shares
S Standard Life Aberdeen plc Institution	−$9.0M −214.1K shares	Sold Off 0 shares
T Tri Locum Partners LP Hedge Fund•Long/Short	−$6.3M −119.4K shares	$4.0M 76.0K shares
Soleus Capital Management, L.P. Hedge Fund•Long/Short	−$5.7M −107.6K shares	$45.5M 859.2K shares
Logos Global Management LP Hedge Fund•Long/Short	−$5.3M −100.0K shares	$6.6M 125.0K shares

Entry and Exit Activity

Institutions that initiated new positions or completely exited PRAX in Q3 2025

New Positions: 11
New Value: $14.9M
Exited Positions: 19
Exited Value: $44.9M

New Positions

Institution	Position Value
R READYSTATE ASSET MANAGEMENT LP Hedge Fund•Multi-Strategy	$5.8M 109.2K shares
SummitTX Capital, L.P. Hedge Fund•Multi-Strategy	$1.9M 34.9K shares
CONGRESS ASSET MANAGEMENT CO /MA Long Only Manager	$1.6M 30.4K shares
FIRST TRUST ADVISORS LP ETF Provider	$1.5M 29.0K shares
K Knott David M Jr Institution	$1.5M 28.0K shares
D DARK FOREST CAPITAL MANAGEMENT LP Pension/Endowment	$1.1M 21.7K shares
H HSBC HOLDINGS PLC Institution	$594.7K 11.2K shares
P Phoenix Holdings Ltd. Institution	$361.5K 6.8K shares
L Lion Point Capital, LP Hedge Fund•Event Driven	$302.1K 5.7K shares
V VIRGINIA RETIREMENT SYSTEMS ET AL Institution	$206.7K 3.9K shares

Exited Positions

Institution	Previous Position
BALYASNY ASSET MANAGEMENT LLC Hedge Fund•Multi-Strategy	$15.5M 369.3K shares
S Standard Life Aberdeen plc Institution	$9.0M 214.1K shares
Verition Fund Management LLC Hedge Fund•Multi-Strategy	$5.0M 118.5K shares
Schonfeld Strategic Advisors LLC Hedge Fund•Multi-Strategy	$4.2M 100.7K shares
Ally Bridge Group LLC Hedge Fund•Sector	$3.4M 80.9K shares
Pictet Asset Management Holding SA Long Only Manager	$3.3M 79.1K shares
StemPoint Capital LP Hedge Fund•Long/Short	$1.4M 32.3K shares
CAPITAL FUND MANAGEMENT S.A. Hedge Fund•Quant Macro	$1.0M 24.3K shares
UBS OCONNOR LLC Long Only Manager	$920.6K 21.9K shares
B Brevan Howard Capital Management LP Institution	$357.6K 8.5K shares

Options Activity

Institutions with the largest Call and Put options positions in PRAX as of Q3 2025

Call Positions: 11
Call Value: $26.5M
Put Positions: 11
Put Value: $20.0M

Call Positions

Institution	Position Value
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$5.4M 1.0K contracts
Ikarian Capital, LLC Hedge Fund•Event Driven	$5.3M 1.0K contracts
Ally Bridge Group LLC Hedge Fund•Sector	$5.3M 1.0K contracts
BOOTHBAY FUND MANAGEMENT, LLC Fund of Funds	$3.0M 564.0 contracts
S SPHERA FUNDS MANAGEMENT LTD. Institution	$2.7M 500.0 contracts
Caption Management, LLC Hedge Fund•Long/Short	$2.3M 435.0 contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$1.3M 243.0 contracts
J JANE STREET GROUP, LLC Institution	$858.6K 162.0 contracts
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	$424.0K 80.0 contracts
LEUCADIA NATIONAL CORP Institution	- - contracts

Put Positions

Institution	Position Value
Caption Management, LLC Hedge Fund•Long/Short	$7.6M 1.4K contracts
DIADEMA PARTNERS LP Hedge Fund•Long/Short	$5.3M 1.0K contracts
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$4.3M 816.0 contracts
LEUCADIA NATIONAL CORP Institution	$1.4M 270.0 contracts
J JANE STREET GROUP, LLC Institution	$651.9K 123.0 contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$646.6K 122.0 contracts
BANK OF AMERICA CORP /DE/ Institution	- - contracts
UBS Group AG Institution	- - contracts
S SIG BROKERAGE, LP Institution	- - contracts
6 683 Capital Management, LLC Hedge Fund•Long/Short	- - contracts

Most Committed Institutions

Institutions with PRAX as the highest % of their portfolio as of Q3 2025

Institution	Key People	Portfolio Weight	Ownership	Owned Since	Total AUM (Long)
V Velan Capital Investment Management LP Institution	-	6.61% $7.0M	0.63% 132.8K shares	Q1 2023 Held for 2y 8m	$106.5M
7 72 Investment Holdings, LLC Institution	-	5.14% $3.5M	0.31% 65.9K shares	Q4 2020 Held for 4y 11m	$67.9M
C Cormorant Asset Management, LLC Hedge Fund•Long/Short	Bihua Chen CEO	4.13% $53.0M	4.75% 1.0M shares	Q2 2023 Held for 2y 5m	$1.3B
Exome Asset Management LLC Hedge Fund•Sector	Alex R Forschner President	3.65% $5.4M	0.48% 102.0K shares	Q2 2025 Held for 5 months	$148.0M
5 5AM Venture Management, LLC Institution	-	3.30% $9.0M	0.81% 170.0K shares	Q1 2024 Held for 1y 8m	$273.0M
L Longwood Capital Partners LLC Institution	-	2.72% $2.6M	0.24% 49.8K shares	Q2 2023 Held for 2y 5m	$96.8M
Soleus Capital Management, L.P. Hedge Fund•Long/Short	Guy Bezalel Levy CIO	2.49% $45.5M	4.08% 859.2K shares	Q2 2023 Held for 2y 5m	$1.8B
PERCEPTIVE ADVISORS LLC Hedge Fund•Long/Short	Joseph Eric Edelman CEO	2.40% $82.9M	7.43% 1.6M shares	Q1 2024 Held for 1y 8m	$3.5B
B B Group, Inc. Institution	-	1.93% $1.7M	0.15% 31.5K shares	Q1 2025 Held for 8 months	$86.6M
L Lion Point Capital, LP Hedge Fund•Event Driven	Carl Didric Marcus Cederholm CIO	1.72% $302.1K	0.03% 5.7K shares	Q3 2025 Held for 2 months	$17.6M

Hedge Fund Spotlight

Discover hedge funds investing in PRAX

Logos Global Management LP

Hedge Fund • Long/Short

Portfolio ManagerGraham Gordon Walmsley

Portfolio Value: $987.5M
Positions: 51
Last Reported: Q3 2025

Sector Allocation

Position in Praxis Precision Medicines, Inc.

Market Value: $6.6M
Shares Held: 125.0K
Portfolio Weight: 0.67%
Owned Since: 2025-Q2

Top Holding	Sector	Market Value	Weight
1 Revolution Medicines, Inc. RVMD	Biotechnology Healthcare	$81.7M	8.28%
2 IDEAYA Biosciences, Inc. IDYA	Biotechnology Healthcare	$61.2M	6.20%
3 Akero Therapeutics AKRO	Biotechnology Healthcare	$57.0M	5.77%