Avidity Biosciences

RNA • NASDAQ

Avidity Biosciences is a biotechnology company in the healthcare sector on NASDAQ, led by Sarah Boyce, with a market cap of $10.9B. As of Q3 2025, 110% of shares are held by 264 institutional investors, with FMR LLC as the largest holder at 14.79%.

CEOSarah Boyce

Market Cap$10.9B

Biotechnology

Healthcare

Employees253.0

Websiteaviditybiosciences.com

Country

United States of America

Overview

Overview of institutional ownership in RNA as of Q3 2025 with a market cap of $6.4B

All Institutions

Institutions: 264
Value Held: $7.0B
Shares Held: 160.8M
Avg Position: $26.5M
Median Position: $1.3M

Hedge Funds

Hedge Funds: 36
Value Held: $1.3B
Shares Held: 30.7M
Avg Position: $37.1M
Median Position: $4.8M

Ownership Breakdown

Institutional (non-HF)

89.14%

$5.7B

Hedge Funds

21.02%

$1.3B

Retail & Other

Based on market cap of $6.4B as of Q3 2025. Institutional (non-HF) excludes hedge funds to avoid double counting.

Biggest Investors

Institutions with the largest positions in RNA as of Q3 2025

Institution	Key People	Position Value	Ownership	Owned Since	Total AUM (Long)
FMR LLC Institution	-	$940.5M 0.05% of portfolio	14.79% 21.6M shares	Q2 2020 Held for 5y 6m	$1.92T
HENDERSON GROUP PLC Institution	Ali Dibadj CEO	$632.8M 0.29% of portfolio	9.95% 14.5M shares	Q1 2023 Held for 2y 9m	$218.74B
VANGUARD GROUP INC Institution	Salim Ramji CEO	$576.0M 0.01% of portfolio	9.06% 13.2M shares	Q2 2020 Held for 5y 6m	$6.69T
RTW INVESTMENTS, LLC Hedge Fund•Sector	Peter M Fong President	$495.5M 6.15% of portfolio	7.79% 11.4M shares	Q2 2020 Held for 5y 6m	$8.1B
WELLINGTON MANAGEMENT CO LLP Long Only Manager	Jean Marie Hynes CEO	$438.5M 0.08% of portfolio	6.90% 10.1M shares	Q2 2020 Held for 5y 6m	$571.21B
PRICE T ROWE ASSOCIATES INC /MD/ Long Only Manager	Robert W Sharps President	$426.4M 0.05% of portfolio	6.71% 9.8M shares	Q2 2020 Held for 5y 6m	$912.31B
BlackRock, Inc. Institution	Laurence D. Fink CEO	$401.0M 0.01% of portfolio	6.31% 9.2M shares	Q2 2020 Held for 5y 6m	$5.67T
RA CAPITAL MANAGEMENT, LLC Hedge Fund•Long/Short	Michael Saulnier CFO	$376.5M 4.68% of portfolio	5.92% 8.6M shares	Q3 2021 Held for 4y 3m	$8.1B
venBio Select Advisor LLC RIA/Wealth	Behzad Aghazadeh Managing Partner	$333.1M 4.31% of portfolio	5.24% 7.6M shares	Q2 2020 Held for 5y 6m	$7.7B
STATE STREET CORP Institution	Ronald P. O'Hanley CEO	$213.0M 0.01% of portfolio	3.35% 4.9M shares	Q3 2020 Held for 5y 3m	$2.88T

Net Capital Flow

Institutional buying and selling activity for RNA in Q3 2025

Traded: +$1.2B
Buyers: 191
Sellers: 69
Total Bought: +$1.5B
Total Sold: −$286.9M
Avg Position: $25.0M

Biggest Buyers

Institution	Net Bought	Current Position
FMR LLC Institution	+$235.3M +5.4M shares	$940.5M 21.6M shares
VANGUARD GROUP INC Institution	+$173.0M +4.0M shares	$576.0M 13.2M shares
HENDERSON GROUP PLC Institution	+$163.2M +3.7M shares	$632.8M 14.5M shares
B Bellevue Group AG Institution	+$93.8M +2.2M shares	$93.8M 2.2M shares
RTW INVESTMENTS, LLC Hedge Fund•Sector	+$76.4M +1.8M shares	$495.5M 11.4M shares
RA CAPITAL MANAGEMENT, LLC Hedge Fund•Long/Short	+$59.9M +1.4M shares	$376.5M 8.6M shares
Polar Capital Holdings Plc Long Only Manager	+$44.7M +1.0M shares	$121.9M 2.8M shares
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	+$38.3M +878.0K shares	$39.2M 899.8K shares
WELLINGTON MANAGEMENT CO LLP Long Only Manager	+$35.5M +815.5K shares	$438.5M 10.1M shares
SUVRETTA CAPITAL MANAGEMENT, LLC Hedge Fund•Long/Short	+$32.7M +750.0K shares	$32.7M 750.0K shares

Biggest Sellers

Institution	Net Sold	Current Position
TORONTO DOMINION BANK Institution	−$100.3M −3.5M shares	Sold Off 0 shares
PRICE T ROWE ASSOCIATES INC /MD/ Long Only Manager	−$44.5M −1.0M shares	$426.4M 9.8M shares
Logos Global Management LP Hedge Fund•Long/Short	−$15.2M −350.0K shares	$26.1M 600.0K shares
A ADAGE CAPITAL PARTNERS GP LLC Institution	−$14.2M −327.0K shares	$52.3M 1.2M shares
Woodline Partners LP Hedge Fund•Long/Short	−$13.6M −311.3K shares	$14.1M 323.8K shares
R ROYAL BANK OF CANADA Institution	−$12.6M −290.2K shares	$13.8M 316.5K shares
CITIGROUP INC Institution	−$11.4M −260.5K shares	$1.3M 29.3K shares
UBS GLOBAL ASSET MANAGEMENT AMERICAS INC Long Only Manager	−$9.7M −222.0K shares	$7.6M 174.0K shares
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	−$9.0M −207.4K shares	$1.3M 29.6K shares
ORBIMED ADVISORS LLC Hedge Fund•Sector	−$7.6M −174.0K shares	$71.4M 1.6M shares

Entry and Exit Activity

Institutions that initiated new positions or completely exited RNA in Q3 2025

New Positions: 54
New Value: $237.6M
Exited Positions: 14
Exited Value: $114.0M

New Positions

Institution	Position Value
B Bellevue Group AG Institution	$93.8M 2.2M shares
SUVRETTA CAPITAL MANAGEMENT, LLC Hedge Fund•Long/Short	$32.7M 750.0K shares
Clearbridge Investments, LLC Long Only Manager	$32.3M 741.7K shares
B BRAIDWELL LP Hedge Fund•Multi-Strategy	$14.5M 331.9K shares
Eversept Partners, LLC Hedge Fund•Long/Short	$13.2M 302.9K shares
University of Wisconsin Foundation RIA/Wealth	$12.6M 289.2K shares
Catalio Capital Management, LP Venture Capital	$11.5M 263.3K shares
StemPoint Capital LP Hedge Fund•Long/Short	$5.0M 114.1K shares
Burkehill Global Management, LP Hedge Fund•Event Driven	$2.6M 60.0K shares
M MAVEN SECURITIES Ltd Private Equity	$2.6M 60.0K shares

Exited Positions

Institution	Previous Position
TORONTO DOMINION BANK Institution	$100.3M 3.5M shares
Ally Bridge Group LLC Hedge Fund•Sector	$3.8M 132.7K shares
S SPHERA FUNDS MANAGEMENT LTD. Institution	$3.6M 126.0K shares
A AXA Institution	$2.9M 101.4K shares
Aquatic Capital Management LLC Hedge Fund•Quant	$1.8M 62.1K shares
S SUPERSTRING CAPITAL MANAGEMENT LP Hedge Fund•Long/Short	$1.3M 47.0K shares
C CI Private Wealth, LLC RIA/Wealth	$282.1K 9.9K shares
Mount Yale Investment Advisors, LLC RIA/Wealth	$49.0K 1.7K shares
B BNP Paribas Investment Partners S.A. Institution	$23.3K 822.0 shares
Quantbot Technologies LLC Hedge Fund•Quant	$4.1K 143.0 shares

Options Activity

Institutions with the largest Call and Put options positions in RNA as of Q3 2025

Call Positions: 14
Call Value: $54.0M
Put Positions: 12
Put Value: $23.1M

Call Positions

Institution	Position Value
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$18.0M 4.1K contracts
Caption Management, LLC Hedge Fund•Long/Short	$11.6M 2.7K contracts
DIADEMA PARTNERS LP Hedge Fund•Long/Short	$8.7M 2.0K contracts
J JANE STREET GROUP, LLC Institution	$5.3M 1.2K contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$4.2M 969.0 contracts
P PEAK6 LLC Institution	$2.2M 509.0 contracts
W WOLVERINE TRADING, LLC Institution	$1.0M 240.0 contracts
Pentwater Capital Management LP Hedge Fund•Event Driven	$871.4K 200.0 contracts
S Squarepoint Ops LLC Hedge Fund•Quant	$845.3K 194.0 contracts
H HARVEST MANAGEMENT LLC Hedge Fund•Event Driven	$653.6K 150.0 contracts

Put Positions

Institution	Position Value
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$8.5M 2.0K contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$5.7M 1.3K contracts
J JANE STREET GROUP, LLC Institution	$2.5M 585.0 contracts
Caption Management, LLC Hedge Fund•Long/Short	$1.7M 400.0 contracts
R RK Capital Management, LLC/FL RIA/Wealth	$1.7M 386.0 contracts
S Squarepoint Ops LLC Hedge Fund•Quant	$1.1M 251.0 contracts
Centiva Capital, LP Hedge Fund•Multi-Strategy	$653.6K 150.0 contracts
W WOLVERINE TRADING, LLC Institution	$456.1K 107.0 contracts
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	$344.2K 79.0 contracts
TUDOR INVESTMENT CORP ET AL Hedge Fund•Multi-Strategy	$217.9K 50.0 contracts

Most Committed Institutions

Institutions with RNA as the highest % of their portfolio as of Q3 2025

Institution	Key People	Portfolio Weight	Ownership	Owned Since	Total AUM (Long)
Alethea Capital Management, LLC Hedge Fund•Multi-Strategy	Tony Hsu Managing Partner	12.51% $19.4M	0.31% 446.1K shares	Q4 2020 Held for 5 years	$155.4M
University of Wisconsin Foundation RIA/Wealth	Scott Allen Hayes President	10.67% $12.6M	0.20% 289.2K shares	Q3 2025 Held for 3 months	$118.1M
Casdin Capital, LLC Hedge Fund•Sector	Eli D Casdin Managing Partner	6.71% $77.6M	1.22% 1.8M shares	Q4 2022 Held for 3 years	$1.2B
RTW INVESTMENTS, LLC Hedge Fund•Sector	Peter M Fong President	6.15% $495.5M	7.79% 11.4M shares	Q2 2020 Held for 5y 6m	$8.1B
MPM Oncology Impact Management LP Institution	Christian Albrecht Wulf Von Schimmelmann Managing Partner	5.42% $33.1M	0.52% 760.0K shares	Q2 2024 Held for 1y 6m	$610.9M
SILVERARC CAPITAL MANAGEMENT, LLC Hedge Fund•Long/Short	Devesh Sharad Gandhi Founder	5.34% $36.8M	0.58% 844.6K shares	Q1 2024 Held for 1y 9m	$689.7M
RA CAPITAL MANAGEMENT, LLC Hedge Fund•Long/Short	Michael Saulnier CFO	4.68% $376.5M	5.92% 8.6M shares	Q3 2021 Held for 4y 3m	$8.1B
venBio Select Advisor LLC RIA/Wealth	Behzad Aghazadeh Managing Partner	4.31% $333.1M	5.24% 7.6M shares	Q2 2020 Held for 5y 6m	$7.7B
R RK Capital Management, LLC/FL RIA/Wealth	Jordan Robert Abisch Managing Partner	3.95% $2.6M	0.04% 58.6K shares	Q3 2025 Held for 3 months	$64.6M
Logos Global Management LP Hedge Fund•Long/Short	Arsani Hany William Managing Partner	2.65% $26.1M	0.41% 600.0K shares	Q1 2025 Held for 9 months	$987.5M

Hedge Fund Spotlight

Discover hedge funds investing in RNA

Caption Management, LLC

Hedge Fund • Long/Short

Portfolio ManagerWilliam Lamblè Cooper

Portfolio Value: $1.7B
Positions: 577
Last Reported: Q3 2025

Sector Allocation

Position in Avidity Biosciences

Market Value: $528.9K
Shares Held: 12.1K
Portfolio Weight: 0.03%
Owned Since: 2024-Q4

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