Xeris Biopharma Holdings, Inc.

XERS • NASDAQ

Xeris Biopharma Holdings, Inc. is a biotechnology company in the healthcare sector on NASDAQ, led by John Shannon, with a market cap of $1.2B. As of Q3 2025, 60% of shares are held by 231 institutional investors, with BlackRock, Inc. as the largest holder at 7.39%.

Chief Executive OfficerJohn Shannon

Market Cap$1.2B

Biotechnology

Healthcare

Employees377.0

Websitexerispharma.com

Country

United States of America

Overview

Overview of institutional ownership in XERS as of Q3 2025 with a market cap of $1.3B

All Institutions

Institutions: 231
Value Held: $790.3M
Shares Held: 97.2M
Avg Position: $3.4M
Median Position: $385.5K

Hedge Funds

Hedge Funds: 43
Value Held: $133.2M
Shares Held: 16.4M
Avg Position: $3.1M
Median Position: $675.6K

Ownership Breakdown

Institutional (non-HF)

49.99%

$657.1M

Hedge Funds

10.14%

$133.2M

Retail & Other

39.88%

$524.2M

Based on market cap of $1.3B as of Q3 2025. Institutional (non-HF) excludes hedge funds to avoid double counting.

Biggest Investors

Institutions with the largest positions in XERS as of Q3 2025

Institution	Key People	Position Value	Ownership	Owned Since	Total AUM (Long)
B BlackRock, Inc. Institution	-	$97.1M 0.00% of portfolio	7.39% 11.9M shares	Q2 2018 Held for 7y 5m	$5.67T
VANGUARD GROUP INC Institution	Salim Ramji CEO	$80.0M 0.00% of portfolio	6.09% 9.8M shares	Q2 2018 Held for 7y 5m	$6.69T
D D. E. Shaw & Co., Inc. Institution	-	$47.5M 0.04% of portfolio	3.62% 5.8M shares	Q1 2022 Held for 3y 8m	$115.81B
GEODE CAPITAL MANAGEMENT LLC ETF Provider	David Kenneth Lane CEO	$33.7M 0.00% of portfolio	2.56% 4.1M shares	Q3 2018 Held for 7y 2m	$1.57T
STATE STREET CORP Institution	Ronald P. O'Hanley CEO	$30.4M 0.00% of portfolio	2.32% 3.7M shares	Q3 2018 Held for 7y 2m	$2.88T
Q Qube Research & Technologies Ltd Institution	-	$26.7M 0.04% of portfolio	2.03% 3.3M shares	Q3 2023 Held for 2y 2m	$70.6B
MORGAN STANLEY RIA/Wealth	Jed Finn CEO	$26.2M 0.00% of portfolio	1.99% 3.2M shares	Q2 2018 Held for 7y 5m	$1.65T
N Nuveen, LLC Institution	-	$23.0M 0.01% of portfolio	1.75% 2.8M shares	Q1 2025 Held for 8 months	$377.89B
DRIEHAUS CAPITAL MANAGEMENT LLC Hedge Fund•Event Driven	Stephen Thomas Weber CEO	$21.3M 0.15% of portfolio	1.62% 2.6M shares	Q4 2024 Held for 11 months	$13.9B
R Rosalind Advisors, Inc. Institution	-	$14.6M 5.54% of portfolio	1.11% 1.8M shares	Q4 2023 Held for 1y 11m	$263.6M

Net Capital Flow

Institutional buying and selling activity for XERS in Q3 2025

Traded: +$67.0M
Buyers: 138
Sellers: 85
Total Bought: +$146.0M
Total Sold: −$79.0M
Avg Position: $3.1M

Biggest Buyers

Institution	Net Bought	Current Position
D D. E. Shaw & Co., Inc. Institution	+$16.3M +2.0M shares	$47.5M 5.8M shares
UBS Group AG Institution	+$12.7M +1.6M shares	$14.5M 1.8M shares
J JANE STREET GROUP, LLC Institution	+$7.2M +882.6K shares	$7.4M 913.8K shares
SCHWAB CHARLES INVESTMENT MANAGEMENT INC Long Only Manager	+$7.2M +879.1K shares	$11.8M 1.4M shares
$DEUTSCHE BANK AG\ logo$ DEUTSCHE BANK AG\ Institution	+$6.8M +830.7K shares	$12.8M 1.6M shares
B BNP PARIBAS ARBITRAGE, SA Institution	+$4.6M +565.4K shares	$4.7M 581.7K shares
DRIEHAUS CAPITAL MANAGEMENT LLC Hedge Fund•Event Driven	+$4.5M +548.1K shares	$21.3M 2.6M shares
ACADIAN ASSET MANAGEMENT LLC Long Only Manager	+$4.4M +537.9K shares	$7.5M 921.1K shares
Invesco Ltd. ETF Provider	+$4.0M +496.9K shares	$4.7M 583.1K shares
GEODE CAPITAL MANAGEMENT LLC ETF Provider	+$4.0M +489.5K shares	$33.7M 4.1M shares

Biggest Sellers

Institution	Net Sold	Current Position
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	−$19.6M −2.4M shares	$4.3M 524.7K shares
CenterBook Partners LP Hedge Fund•Market Neutral	−$7.3M −896.0K shares	$5.7M 698.2K shares
C Cubist Systematic Strategies, LLC Institution	−$4.1M −880.3K shares	Sold Off 0 shares
GOLDMAN SACHS GROUP INC Institution	−$3.9M −476.0K shares	$14.6M 1.8M shares
L LEGAL & GENERAL GROUP PLC Institution	−$3.6M −446.8K shares	$11.0M 1.4M shares
RENAISSANCE TECHNOLOGIES LLC Hedge Fund•Quant	−$3.5M −432.5K shares	$13.2M 1.6M shares
MORGAN STANLEY RIA/Wealth	−$3.4M −422.9K shares	$26.2M 3.2M shares
R Rosalind Advisors, Inc. Institution	−$2.9M −359.8K shares	$14.6M 1.8M shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	−$2.6M −324.7K shares	$663.2K 81.5K shares
Parkman Healthcare Partners LLC Hedge Fund•Long/Short	−$2.6M −315.8K shares	$14.6M 1.8M shares

Entry and Exit Activity

Institutions that initiated new positions or completely exited XERS in Q3 2025

New Positions: 40
New Value: $18.8M
Exited Positions: 26
Exited Value: $10.6M

New Positions

Institution	Position Value
D Divisadero Street Capital Management, LP Hedge Fund•Long/Short	$3.3M 406.3K shares
C CANADA PENSION PLAN INVESTMENT BOARD Institution	$3.1M 375.7K shares
S Swiss National Bank Institution	$2.5M 310.4K shares
Calamos Advisors LLC Long Only Manager	$1.1M 137.1K shares
D DARK FOREST CAPITAL MANAGEMENT LP Pension/Endowment	$1.1M 136.7K shares
CWM Advisors, LLC ETF Provider	$1.0M 128.5K shares
W Winton Capital Group Ltd Institution	$739.1K 90.8K shares
DIADEMA PARTNERS LP Hedge Fund•Long/Short	$608.5K 74.8K shares
Round Rock Advisors, LLC RIA/Wealth	$582.2K 63.8K shares
HENDERSON GROUP PLC Institution	$569.2K 69.9K shares

Exited Positions

Institution	Previous Position
C Cubist Systematic Strategies, LLC Institution	$4.1M 880.3K shares
S Stonepine Capital Management, LLC Institution	$957.8K 205.1K shares
JACOBS LEVY EQUITY MANAGEMENT, INC Hedge Fund•Quant	$849.4K 181.9K shares
A Alpine Partners VI, LLC Institution	$700.5K 150.0K shares
O OPTIONS SOLUTIONS, LLC Hedge Fund•Sector	$621.1K 133.0K shares
M Man Group plc Institution	$611.1K 130.8K shares
Graham Capital Management, L.P. Hedge Fund•Multi-Strategy	$585.7K 125.4K shares
B BROWN ADVISORY INC RIA/Wealth	$535.6K 114.7K shares
C CI Private Wealth, LLC RIA/Wealth	$319.9K 68.5K shares
Chevy Chase Trust Holdings, Inc. RIA/Wealth	$239.3K 51.2K shares

Options Activity

Institutions with the largest Call and Put options positions in XERS as of Q3 2025

Call Positions: 3
Call Value: $1.8M
Put Positions: 2
Put Value: $503.1K

Call Positions

Institution	Position Value
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$1.5M 1.9K contracts
J JANE STREET GROUP, LLC Institution	$306.9K 377.0 contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	- - contracts

Put Positions

Institution	Position Value
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$383.4K 471.0 contracts
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$119.7K 147.0 contracts

Most Committed Institutions

Institutions with XERS as the highest % of their portfolio as of Q3 2025

Institution	Key People	Portfolio Weight	Ownership	Owned Since	Total AUM (Long)
R Rosalind Advisors, Inc. Institution	-	5.54% $14.6M	1.11% 1.8M shares	Q4 2023 Held for 1y 11m	$263.6M
K Knott David M Jr Institution	-	3.46% $8.3M	0.63% 1.0M shares	Q4 2023 Held for 1y 11m	$238.7M
Parkman Healthcare Partners LLC Hedge Fund•Long/Short	Gregory Arthur Martinez CIO	1.60% $14.6M	1.11% 1.8M shares	Q1 2024 Held for 1y 8m	$910.1M
ESSEX INVESTMENT MANAGEMENT CO LLC Long Only Manager	Nancy Beth Prial CEO	0.94% $6.1M	0.46% 750.0K shares	Q4 2024 Held for 11 months	$652.5M
EAM Investors, LLC Long Only Manager	Derek John Gaertner CEO	0.56% $4.9M	0.37% 603.1K shares	Q4 2024 Held for 11 months	$873.4M
Harvest Investment Services, LLC RIA/Wealth	Timothy John Newell CEO	0.54% $2.7M	0.20% 325.6K shares	Q1 2025 Held for 8 months	$490.4M
DIADEMA PARTNERS LP Hedge Fund•Long/Short	Timothy Beau Bassett CIO	0.42% $608.5K	0.05% 74.8K shares	Q3 2025 Held for 2 months	$143.3M
R Redmile Group, LLC Hedge Fund•Sector	Amrit Nmn Nagpal Managing Partner	0.36% $3.7M	0.28% 451.1K shares	Q2 2018 Held for 7y 5m	$1.0B
Semanteon Capital Management, LP Hedge Fund•Long/Short	Rajat Lal Managing Partner	0.34% $268.0K	0.02% 32.9K shares	Q1 2025 Held for 8 months	$79.7M
CenterBook Partners LP Hedge Fund•Market Neutral	David Israel Stemerman CEO	0.28% $5.7M	0.43% 698.2K shares	Q4 2023 Held for 1y 11m	$2.0B

Hedge Fund Spotlight

Discover hedge funds investing in XERS

Weiss Asset Management LP

Hedge Fund • Multi-Strategy

Portfolio ManagerAndrew Murray Weiss

Portfolio Value: $5.2B
Positions: 533
Last Reported: Q3 2025

Sector Allocation

Position in Xeris Biopharma Holdings, Inc.

Market Value: $407.0K
Shares Held: 50.0K
Portfolio Weight: 0.01%
Owned Since: 2024-Q1

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