Zentalis Pharmaceuticals, Inc.

ZNTL • NASDAQ

Zentalis Pharmaceuticals, Inc. is a biotechnology company in the healthcare sector on NASDAQ, led by Julie Eastland, with a market cap of $101.2M. As of Q3 2025, 73% of shares are held by 98 institutional investors, with Matrix Capital Management Company, LLC as the largest holder at 19.35%.

Chief Executive Officer, PresidentJulie Eastland

Market Cap$101.2M

Biotechnology

Healthcare

Employees168.0

Websitezentalis.com

Country

United States of America

Overview

Overview of institutional ownership in ZNTL as of Q3 2025 with a market cap of $108.9M

All Institutions

Institutions: 98
Value Held: $79.7M
Shares Held: 52.8M
Avg Position: $813.1K
Median Position: $131.5K

Hedge Funds

Hedge Funds: 22
Value Held: $40.2M
Shares Held: 26.6M
Avg Position: $1.8M
Median Position: $353.9K

Ownership Breakdown

Institutional (non-HF)

36.3%

$39.5M

Hedge Funds

36.86%

$40.2M

Retail & Other

26.84%

$29.2M

Based on market cap of $108.9M as of Q3 2025. Institutional (non-HF) excludes hedge funds to avoid double counting.

Biggest Investors

Institutions with the largest positions in ZNTL as of Q3 2025

Institution	Key People	Position Value	Ownership	Owned Since	Total AUM (Long)
M Matrix Capital Management Company, LLC Hedge Fund•Long/Short	Christopher David Johnson CFO	$21.1M 19.75% of portfolio	19.35% 14.0M shares	Q2 2020 Held for 5y 5m	$106.7M
VANGUARD GROUP INC Institution	Salim Ramji CEO	$4.4M 0.00% of portfolio	4.03% 2.9M shares	Q2 2020 Held for 5y 5m	$6.69T
ACADIAN ASSET MANAGEMENT LLC Long Only Manager	Gillian Morna Therese Savage CEO	$4.3M 0.01% of portfolio	3.94% 2.8M shares	Q3 2024 Held for 1y 2m	$51.5B
RENAISSANCE TECHNOLOGIES LLC Hedge Fund•Quant	Peter Fitzhugh Brown CEO	$3.5M 0.00% of portfolio	3.22% 2.3M shares	Q1 2023 Held for 2y 8m	$75.8B
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	Kenneth Cordele Griffin CEO	$3.1M 0.00% of portfolio	2.88% 2.1M shares	Q2 2020 Held for 5y 5m	$122.08B
T TANG CAPITAL MANAGEMENT LLC Institution	-	$2.3M 0.09% of portfolio	2.15% 1.6M shares	Q1 2025 Held for 8 months	$2.5B
BANK OF AMERICA CORP /DE/ Institution	Brian T. Moynihan CEO	$2.3M 0.00% of portfolio	2.15% 1.5M shares	Q2 2020 Held for 5y 5m	$1.33T
TWO SIGMA ADVISERS, LLC Hedge Fund•Multi-Strategy	Scott David Hoffman CEO	$2.2M 0.00% of portfolio	2.03% 1.5M shares	Q1 2024 Held for 1y 8m	$50.0B
D D. E. Shaw & Co., Inc. Institution	-	$2.1M 0.00% of portfolio	1.95% 1.4M shares	Q3 2023 Held for 2y 2m	$115.81B
MORGAN STANLEY RIA/Wealth	Jed Finn CEO	$2.1M 0.00% of portfolio	1.95% 1.4M shares	Q2 2020 Held for 5y 5m	$1.65T

Net Capital Flow

Institutional buying and selling activity for ZNTL in Q3 2025

Traded: −$4.0M
Buyers: 42
Sellers: 54
Total Bought: +$10.0M
Total Sold: −$14.0M
Avg Position: $658.6K

Biggest Buyers

Institution	Net Bought	Current Position
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	+$2.4M +1.6M shares	$3.1M 2.1M shares
BANK OF AMERICA CORP /DE/ Institution	+$1.3M +835.5K shares	$2.3M 1.5M shares
RENAISSANCE TECHNOLOGIES LLC Hedge Fund•Quant	+$1.2M +795.8K shares	$3.5M 2.3M shares
UBS Group AG Institution	+$608.8K +403.2K shares	$804.3K 532.7K shares
S Stonepine Capital Management, LLC Institution	+$520.6K +344.8K shares	$685.2K 453.8K shares
MORGAN STANLEY RIA/Wealth	+$468.4K +310.2K shares	$2.1M 1.4M shares
X XTX Topco Ltd Institution	+$428.5K +283.8K shares	$828.4K 548.6K shares
TWO SIGMA INVESTMENTS LLC Hedge Fund•Multi-Strategy	+$408.1K +270.3K shares	$2.1M 1.4M shares
Creative Planning RIA/Wealth	+$346.8K +229.7K shares	$392.6K 260.0K shares
BALYASNY ASSET MANAGEMENT LLC Hedge Fund•Multi-Strategy	+$324.1K +214.7K shares	$1.8M 1.2M shares

Biggest Sellers

Institution	Net Sold	Current Position
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	−$3.9M −2.6M shares	$1.4M 902.5K shares
O Opaleye Management Inc. Hedge Fund•Long/Short	−$2.4M −1.6M shares	$478.0K 316.6K shares
Almitas Capital LLC RIA/Wealth	−$1.7M −1.1M shares	$690.6K 457.3K shares
T TYBOURNE CAPITAL MANAGEMENT HK LTD Institution	−$780.2K −516.7K shares	$1.5M 961.5K shares
GOLDMAN SACHS GROUP INC Institution	−$780.1K −516.6K shares	$521.2K 345.2K shares
B BlackRock, Inc. Institution	−$743.3K −492.2K shares	$1.9M 1.2M shares
AQR CAPITAL MANAGEMENT LLC Hedge Fund•Multi-Strategy	−$495.3K −328.0K shares	$161.5K 107.0K shares
M Man Group plc Institution	−$471.4K −406.3K shares	Sold Off 0 shares
SCHWAB CHARLES INVESTMENT MANAGEMENT INC Long Only Manager	−$388.2K −257.1K shares	$63.4K 42.0K shares
C Cubist Systematic Strategies, LLC Institution	−$377.1K −249.7K shares	$106.6K 70.6K shares

Entry and Exit Activity

Institutions that initiated new positions or completely exited ZNTL in Q3 2025

New Positions: 3
New Value: $188.9K
Exited Positions: 22
Exited Value: $1.2M

New Positions

Institution	Position Value
PANAGORA ASSET MANAGEMENT INC Hedge Fund•Quant	$147.8K 97.9K shares
Voleon Capital Management LP Hedge Fund•Quant	$41.0K 27.2K shares
O Optiver Holding B.V. Institution	$66.0 44.0 shares

Exited Positions

Institution	Previous Position
M Man Group plc Institution	$471.4K 406.3K shares
R Russell Investments Group, Ltd. RIA/Wealth	$175.1K 151.0K shares
S State of Wyoming Institution	$85.6K 73.8K shares
Jain Global LLC Hedge Fund•Multi-Strategy	$83.8K 72.3K shares
THRIVENT FINANCIAL FOR LUTHERANS Insurance Manager	$81.9K 70.6K shares
PRICE T ROWE ASSOCIATES INC /MD/ Long Only Manager	$48.1K 41.5K shares
C CI Private Wealth, LLC RIA/Wealth	$41.5K 35.8K shares
Y Y-Intercept Ltd Institution	$38.0K 32.7K shares
H HSBC HOLDINGS PLC Institution	$33.3K 27.9K shares
D DRW Securities, LLC Institution	$19.5K 16.8K shares

Options Activity

Institutions with the largest Call and Put options positions in ZNTL as of Q3 2025

Call Positions: 0
Call Value: -
Put Positions: 2
Put Value: $65.5K

Call Positions

Institution	Position Value
No call positions found

Put Positions

Institution	Position Value
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$49.8K 330.0 contracts
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$15.7K 104.0 contracts

Most Committed Institutions

Institutions with ZNTL as the highest % of their portfolio as of Q3 2025

Institution	Key People	Portfolio Weight	Ownership	Owned Since	Total AUM (Long)
M Matrix Capital Management Company, LLC Hedge Fund•Long/Short	Christopher David Johnson CFO	19.75% $21.1M	19.35% 14.0M shares	Q2 2020 Held for 5y 5m	$106.7M
T TYBOURNE CAPITAL MANAGEMENT HK LTD Institution	-	4.69% $1.5M	1.33% 961.5K shares	Q2 2020 Held for 5y 5m	$30.9M
P Peapod Lane Capital LLC Institution	-	0.76% $853.9K	0.78% 565.4K shares	Q1 2025 Held for 8 months	$111.8M
S Stonepine Capital Management, LLC Institution	-	0.56% $685.2K	0.63% 453.8K shares	Q1 2025 Held for 8 months	$123.0M
Decheng Capital LLC Venture Capital	Xiangmin Nmn Cui Managing Partner	0.35% $2.0M	1.83% 1.3M shares	Q4 2023 Held for 1y 11m	$573.2M
PFIZER INC Institution	Albert Bourla CEO	0.33% $1.4M	1.32% 953.8K shares	Q4 2024 Held for 11 months	$437.4M
5 5AM Venture Management, LLC Institution	-	0.27% $739.9K	0.68% 490.0K shares	Q2 2023 Held for 2y 5m	$273.0M
Almitas Capital LLC RIA/Wealth	Ronald Dean Mass Managing Partner	0.16% $690.6K	0.63% 457.3K shares	Q3 2024 Held for 1y 2m	$435.9M
GSA CAPITAL PARTNERS LLP Hedge Fund•Quant	David Khabie-Zeitoune CEO	0.14% $1.6M	1.49% 1.1M shares	Q3 2023 Held for 2y 2m	$1.1B
T TANG CAPITAL MANAGEMENT LLC Institution	-	0.09% $2.3M	2.15% 1.6M shares	Q1 2025 Held for 8 months	$2.5B

Hedge Fund Spotlight

Discover hedge funds investing in ZNTL

TWO SIGMA ADVISERS, LLC

Hedge Fund • Multi-Strategy

Portfolio ManagerScott David Hoffman

Portfolio Value: $50.0B
Positions: 2,312
Last Reported: Q3 2025

Sector Allocation

Position in Zentalis Pharmaceuticals, Inc.

Market Value: $2.2M
Shares Held: 1.5M
Portfolio Weight: 0.00%
Owned Since: 2024-Q1

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