Applied Therapeutics

APLT • NASDAQ

Applied Therapeutics is a biotechnology company in the healthcare sector on NASDAQ, led by Les Funtleyder, with a market cap of $33.2M. As of Q3 2025, 66% of shares are held by 69 institutional investors, with T. Rowe Price Investment Management, Inc. as the largest holder at 14.86%.

Interim Chief Executive OfficerLes Funtleyder

Market Cap$33.2M

Biotechnology

Healthcare

Employees26.0

Websiteappliedtherapeutics.com

Country

United States of America

Overview

Overview of institutional ownership in APLT as of Q3 2025 with a market cap of $87.1M

All Institutions

Institutions: 69
Value Held: $57.3M
Shares Held: 94.8M
Avg Position: $830.5K
Median Position: $48.0K

Hedge Funds

Hedge Funds: 13
Value Held: $18.8M
Shares Held: 31.1M
Avg Position: $1.4M
Median Position: $120.3K

Ownership Breakdown

Institutional (non-HF)

44.19%

$38.5M

Hedge Funds

21.59%

$18.8M

Retail & Other

34.22%

$29.8M

Based on market cap of $87.1M as of Q3 2025. Institutional (non-HF) excludes hedge funds to avoid double counting.

Biggest Investors

Institutions with the largest positions in APLT as of Q3 2025

Institution	Key People	Position Value	Ownership	Owned Since	Total AUM (Long)
T T. Rowe Price Investment Management, Inc. Insurance Manager	John Edward Robison President	$12.9M 0.01% of portfolio	14.86% 21.4M shares	Q3 2024 Held for 1y 2m	$161.58B
Vestal Point Capital, LP Hedge Fund•Long/Short	Ryan Christopher Wilder CIO	$8.6M 0.44% of portfolio	9.89% 14.3M shares	Q4 2023 Held for 1y 11m	$2.0B
Propel Bio Management, LLC Hedge Fund•Sector	Leen Kawas Managing Partner	$6.8M 6.83% of portfolio	7.84% 11.3M shares	Q4 2023 Held for 1y 11m	$99.9M
K Knoll Capital Management, LP Institution	-	$4.7M 2.52% of portfolio	5.42% 7.8M shares	Q2 2019 Held for 6y 5m	$186.6M
VANGUARD GROUP INC Institution	Salim Ramji CEO	$3.1M 0.00% of portfolio	3.54% 5.1M shares	Q3 2019 Held for 6y 2m	$6.69T
S Simplify Asset Management Inc. Institution	-	$2.7M 0.17% of portfolio	3.12% 4.5M shares	Q1 2023 Held for 2y 8m	$1.6B
B BlackRock, Inc. Institution	-	$2.3M 0.00% of portfolio	2.67% 3.8M shares	Q2 2019 Held for 6y 5m	$5.67T
PNC FINANCIAL SERVICES GROUP, INC. Institution	William S. Demchak CEO	$1.8M 0.00% of portfolio	2.01% 2.9M shares	Q3 2025 Held for 2 months	$164.83B
Pathstone Holdings, LLC Family Office	Matthew Jacob Fleissig CEO	$1.6M 0.01% of portfolio	1.84% 2.6M shares	Q2 2025 Held for 5 months	$26.2B
Marshall Wace LLP Institution	Diana Lj Harrison President	$1.5M 0.00% of portfolio	1.77% 2.5M shares	Q3 2024 Held for 1y 2m	$90.3B

Net Capital Flow

Institutional buying and selling activity for APLT in Q3 2025

Net Flow: +$2.7M
Buyers: 15
Sellers: 40
Total Bought: +$6.1M
Total Sold: −$3.4M
Avg Position: $739.8K

Biggest Buyers

Institution	Net Bought	Current Position
Vestal Point Capital, LP Hedge Fund•Long/Short	+$1.7M +2.8M shares	$8.6M 14.3M shares
T T. Rowe Price Investment Management, Inc. Insurance Manager	+$1.6M +2.7M shares	$12.9M 21.4M shares
UBS Group AG Institution	+$650.4K +1.1M shares	$1.2M 1.9M shares
A ADAGE CAPITAL PARTNERS GP LLC Institution	+$604.9K +1.0M shares	$1.3M 2.2M shares
Marshall Wace LLP Institution	+$599.1K +998.5K shares	$1.5M 2.5M shares
MORGAN STANLEY RIA/Wealth	+$224.2K +370.7K shares	$431.5K 713.3K shares
VANGUARD GROUP INC Institution	+$223.0K +368.7K shares	$3.1M 5.1M shares
GEODE CAPITAL MANAGEMENT LLC ETF Provider	+$187.3K +309.6K shares	$773.4K 1.3M shares
R ROYAL BANK OF CANADA Institution	+$121.9K +201.5K shares	$122.7K 202.8K shares
STATE STREET CORP Institution	+$100.5K +166.1K shares	$313.7K 518.5K shares

Biggest Sellers

Institution	Net Sold	Current Position
B BlackRock, Inc. Institution	−$832.3K −1.4M shares	$2.3M 3.8M shares
T TANG CAPITAL MANAGEMENT LLC Institution	−$755.4K −2.4M shares	Sold Off 0 shares
Q Qube Research & Technologies Ltd Institution	−$396.4K −655.3K shares	$706.1K 1.2M shares
GOLDMAN SACHS GROUP INC Institution	−$348.2K −575.6K shares	$93.8K 155.1K shares
TWO SIGMA INVESTMENTS LLC Hedge Fund•Multi-Strategy	−$239.3K −395.6K shares	$120.3K 198.9K shares
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	−$147.5K −474.1K shares	Sold Off 0 shares
SCHWAB CHARLES INVESTMENT MANAGEMENT INC Long Only Manager	−$125.5K −403.5K shares	Sold Off 0 shares
AQR CAPITAL MANAGEMENT LLC Hedge Fund•Multi-Strategy	−$107.2K −177.2K shares	$66.4K 109.7K shares
TWO SIGMA ADVISERS, LLC Hedge Fund•Multi-Strategy	−$94.5K −303.9K shares	Sold Off 0 shares
HighTower Advisors, LLC RIA/Wealth	−$68.4K −220.0K shares	Sold Off 0 shares

Entry and Exit Activity

Institutions that initiated new positions or completely exited APLT in Q3 2025

New Positions: 4
New Value: $2.2M
Exited Positions: 15
Exited Value: $1.3M

New Positions

Institution	Position Value
PNC FINANCIAL SERVICES GROUP, INC. Institution	$1.8M 2.9M shares
Hudson Bay Capital Management LP Hedge Fund•Multi-Strategy	$407.6K 673.8K shares
Cresset Asset Management, LLC RIA/Wealth	$10.3K 17.1K shares
Beaumont Capital Management, LLC Long Only Manager	$6.3K 10.4K shares

Exited Positions

Institution	Previous Position
T TANG CAPITAL MANAGEMENT LLC Institution	$755.4K 2.4M shares
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$147.5K 474.1K shares
SCHWAB CHARLES INVESTMENT MANAGEMENT INC Long Only Manager	$125.5K 403.5K shares
TWO SIGMA ADVISERS, LLC Hedge Fund•Multi-Strategy	$94.5K 303.9K shares
HighTower Advisors, LLC RIA/Wealth	$68.4K 220.0K shares
Schonfeld Strategic Advisors LLC Hedge Fund•Multi-Strategy	$61.2K 196.7K shares
Jain Global LLC Hedge Fund•Multi-Strategy	$26.4K 84.9K shares
C CANTOR FITZGERALD, L. P. Institution	$7.8K 25.0K shares
IEQ CAPITAL, LLC RIA/Wealth	$5.1K 16.3K shares
ExodusPoint Capital Management, LP Hedge Fund•Multi-Strategy	$3.3K 10.5K shares

Options Activity

Institutions with the largest Call and Put options positions in APLT as of Q3 2025

Call Positions: 6
Call Value: $215.8K
Put Positions: 3
Put Value: $181.2K

Call Positions

Institution	Position Value
Hudson Bay Capital Management LP Hedge Fund•Multi-Strategy	$79.7K 1.3K contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$50.6K 836.0 contracts
J JANE STREET GROUP, LLC Institution	$30.7K 508.0 contracts
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$24.9K 415.0 contracts
W WOLVERINE TRADING, LLC Institution	$18.4K 301.0 contracts
DIADEMA PARTNERS LP Hedge Fund•Long/Short	$11.5K 190.0 contracts

Put Positions

Institution	Position Value
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$101.9K 1.7K contracts
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$72.8K 1.2K contracts
J JANE STREET GROUP, LLC Institution	$6.5K 108.0 contracts

Most Committed Institutions

Institutions with APLT as the highest % of their portfolio as of Q3 2025

Institution	Key People	Portfolio Weight	Ownership	Owned Since	Total AUM (Long)
Propel Bio Management, LLC Hedge Fund•Sector	Leen Kawas Managing Partner	6.83% $6.8M	7.84% 11.3M shares	Q4 2023 Held for 1y 11m	$99.9M
K Knoll Capital Management, LP Institution	-	2.52% $4.7M	5.42% 7.8M shares	Q2 2019 Held for 6y 5m	$186.6M
Vestal Point Capital, LP Hedge Fund•Long/Short	Ryan Christopher Wilder CIO	0.44% $8.6M	9.89% 14.3M shares	Q4 2023 Held for 1y 11m	$2.0B
S Simplify Asset Management Inc. Institution	-	0.17% $2.7M	3.12% 4.5M shares	Q1 2023 Held for 2y 8m	$1.6B
B Birchview Capital, LP Hedge Fund•Value	Matthew William Strobeck CIO	0.10% $136.1K	0.16% 225.0K shares	Q2 2025 Held for 5 months	$130.3M
Rock Springs Capital Management LP Hedge Fund•Sector	Nnamdi C Etoh CFO	0.07% $1.3M	1.44% 2.1M shares	Q4 2019 Held for 5y 11m	$1.7B
Scientech Research LLC Hedge Fund•Market Neutral	Zheng Zhang Managing Partner	0.02% $63.6K	0.07% 105.1K shares	Q3 2025 Held for 2 months	$283.5M
T T. Rowe Price Investment Management, Inc. Insurance Manager	John Edward Robison President	0.01% $12.9M	14.86% 21.4M shares	Q3 2024 Held for 1y 2m	$161.58B
S SPHERA FUNDS MANAGEMENT LTD. Institution	-	0.01% $30.2K	0.03% 50.0K shares	Q1 2024 Held for 1y 8m	$416.3M
Hennion & Walsh Asset Management, Inc. RIA/Wealth	Kevin Douglas Mahn President	0.01% $171.1K	0.20% 282.8K shares	Q2 2024 Held for 1y 5m	$2.8B

Hedge Fund Spotlight

Discover hedge funds investing in APLT

Rock Springs Capital Management LP

Hedge Fund • Sector

Portfolio ManagerNnamdi C Etoh

Portfolio Value: $1.7B
Positions: 91
Last Reported: Q3 2025

Sector Allocation

Position in Applied Therapeutics

Market Value: $1.3M
Shares Held: 2.1M
Portfolio Weight: 0.07%
Owned Since: 2019-Q4

Top Holding	Sector	Market Value	Weight
1 ARGX argenx ARGX	Unknown Unknown	$105.3M	6.18%
2 Eli Lilly LLY	Drug Manufacturers - General Healthcare	$80.4M	4.72%
3 Rhythm Pharmaceuticals, Inc. RYTM	Biotechnology Healthcare	$72.4M	4.25%

View full profile

Applied Therapeutics

Overview

All Institutions

Hedge Funds

Ownership Breakdown

Biggest Investors

Net Capital Flow

Biggest Buyers

Biggest Sellers

Entry and Exit Activity

New Positions

Exited Positions

Options Activity

Call Positions

Put Positions

Most Committed Institutions

Hedge Fund Spotlight

Position in Applied Therapeutics

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