Applied Therapeutics

APLT • NASDAQ

Applied Therapeutics is a biotechnology company in the healthcare sector on NASDAQ, led by Les D. Funtleyder, with a market cap of $14.7M. As of Q3 2025, 66% of shares are held by 69 institutional investors, with T. Rowe Price Investment Management, Inc. as the largest holder at 14.86%.

CEOLes D. Funtleyder

Market Cap$14.7M

Biotechnology

Healthcare

Employees26.0

Websiteappliedtherapeutics.com

Country

United States of America

Overview

Overview of institutional ownership in APLT as of Q3 2025 with a market cap of $87.1M

All Institutions

Institutions: 69
Value Held: $57.3M
Shares Held: 94.8M
Avg Position: $830.5K
Median Position: $48.0K

Hedge Funds

Hedge Funds: 13
Value Held: $18.8M
Shares Held: 31.1M
Avg Position: $1.4M
Median Position: $120.3K

Ownership Breakdown

Institutional (non-HF)

44.19%

$38.5M

Hedge Funds

21.59%

$18.8M

Retail & Other

34.22%

$29.8M

Based on market cap of $87.1M as of Q3 2025. Institutional (non-HF) excludes hedge funds to avoid double counting.

Biggest Investors

Institutions with the largest positions in APLT as of Q3 2025

Institution	Key People	Position Value	Ownership	Owned Since	Total AUM (Long)
T T. Rowe Price Investment Management, Inc. Insurance Manager	John Edward Robison President	$12.9M 0.01% of portfolio	14.86% 21.4M shares	Q3 2024 Held for 1y 3m	$161.58B
Vestal Point Capital, LP Hedge Fund•Long/Short	Ryan Christopher Wilder CIO	$8.6M 0.44% of portfolio	9.89% 14.3M shares	Q4 2023 Held for 2 years	$2.0B
Propel Bio Management, LLC Hedge Fund•Sector	Leen Kawas Managing Partner	$6.8M 6.83% of portfolio	7.84% 11.3M shares	Q4 2023 Held for 2 years	$99.9M
K Knoll Capital Management, LP Institution	-	$4.7M 2.52% of portfolio	5.42% 7.8M shares	Q2 2019 Held for 6y 6m	$186.6M
VANGUARD GROUP INC Institution	Salim Ramji CEO	$3.1M 0.00% of portfolio	3.54% 5.1M shares	Q3 2019 Held for 6y 3m	$6.69T
S Simplify Asset Management Inc. Institution	-	$2.7M 0.17% of portfolio	3.12% 4.5M shares	Q1 2023 Held for 2y 9m	$1.6B
BlackRock, Inc. Institution	Laurence D. Fink CEO	$2.3M 0.00% of portfolio	2.67% 3.8M shares	Q2 2019 Held for 6y 6m	$5.67T
PNC FINANCIAL SERVICES GROUP, INC. Institution	William S. Demchak CEO	$1.8M 0.00% of portfolio	2.01% 2.9M shares	Q3 2025 Held for 3 months	$164.84B
Pathstone Holdings, LLC Family Office	Matthew Jacob Fleissig CEO	$1.6M 0.01% of portfolio	1.84% 2.6M shares	Q2 2025 Held for 6 months	$26.2B
Marshall Wace LLP Institution	Diana Lj Harrison President	$1.5M 0.00% of portfolio	1.77% 2.5M shares	Q3 2024 Held for 1y 3m	$90.4B

Net Capital Flow

Institutional buying and selling activity for APLT in Q3 2025

Traded: +$5.3M
Buyers: 27
Sellers: 39
Total Bought: +$8.7M
Total Sold: −$3.4M
Avg Position: $674.2K

Biggest Buyers

Institution	Net Bought	Current Position
PNC FINANCIAL SERVICES GROUP, INC. Institution	+$1.8M +2.9M shares	$1.8M 2.9M shares
Vestal Point Capital, LP Hedge Fund•Long/Short	+$1.7M +2.8M shares	$8.6M 14.3M shares
T T. Rowe Price Investment Management, Inc. Insurance Manager	+$1.6M +2.7M shares	$12.9M 21.4M shares
UBS Group AG Institution	+$650.4K +1.1M shares	$1.2M 1.9M shares
A ADAGE CAPITAL PARTNERS GP LLC Institution	+$604.9K +1.0M shares	$1.3M 2.2M shares
Marshall Wace LLP Institution	+$599.1K +998.5K shares	$1.5M 2.5M shares
Hudson Bay Capital Management LP Hedge Fund•Multi-Strategy	+$407.6K +673.8K shares	$407.6K 673.8K shares
Rockefeller Capital Management L.P. Long Only Manager	+$237.1K +391.9K shares	$237.1K 391.9K shares
MORGAN STANLEY RIA/Wealth	+$224.2K +370.7K shares	$431.5K 713.3K shares
VANGUARD GROUP INC Institution	+$223.0K +368.7K shares	$3.1M 5.1M shares

Biggest Sellers

Institution	Net Sold	Current Position
BlackRock, Inc. Institution	−$832.3K −1.4M shares	$2.3M 3.8M shares
T TANG CAPITAL MANAGEMENT LLC Institution	−$755.4K −2.4M shares	Sold Off 0 shares
Q Qube Research & Technologies Ltd Institution	−$396.4K −655.3K shares	$706.1K 1.2M shares
GOLDMAN SACHS GROUP INC Institution	−$348.2K −575.6K shares	$93.8K 155.1K shares
TWO SIGMA INVESTMENTS LLC Hedge Fund•Multi-Strategy	−$239.3K −395.6K shares	$120.3K 198.9K shares
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	−$147.5K −474.1K shares	Sold Off 0 shares
SCHWAB CHARLES INVESTMENT MANAGEMENT INC Long Only Manager	−$125.5K −403.5K shares	Sold Off 0 shares
AQR CAPITAL MANAGEMENT LLC Hedge Fund•Multi-Strategy	−$107.2K −177.2K shares	$66.4K 109.7K shares
TWO SIGMA ADVISERS, LLC Hedge Fund•Multi-Strategy	−$94.5K −303.9K shares	Sold Off 0 shares
HighTower Advisors, LLC RIA/Wealth	−$68.4K −220.0K shares	Sold Off 0 shares

Entry and Exit Activity

Institutions that initiated new positions or completely exited APLT in Q3 2025

New Positions: 4
New Value: $2.2M
Exited Positions: 15
Exited Value: $1.3M

New Positions

Institution	Position Value
PNC FINANCIAL SERVICES GROUP, INC. Institution	$1.8M 2.9M shares
Hudson Bay Capital Management LP Hedge Fund•Multi-Strategy	$407.6K 673.8K shares
Cresset Asset Management, LLC RIA/Wealth	$10.3K 17.1K shares
Beaumont Capital Management, LLC Long Only Manager	$6.3K 10.4K shares

Exited Positions

Institution	Previous Position
T TANG CAPITAL MANAGEMENT LLC Institution	$755.4K 2.4M shares
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$147.5K 474.1K shares
SCHWAB CHARLES INVESTMENT MANAGEMENT INC Long Only Manager	$125.5K 403.5K shares
TWO SIGMA ADVISERS, LLC Hedge Fund•Multi-Strategy	$94.5K 303.9K shares
HighTower Advisors, LLC RIA/Wealth	$68.4K 220.0K shares
Schonfeld Strategic Advisors LLC Hedge Fund•Multi-Strategy	$61.2K 196.7K shares
Jain Global LLC Hedge Fund•Multi-Strategy	$26.4K 84.9K shares
C CANTOR FITZGERALD, L. P. Institution	$7.8K 25.0K shares
IEQ CAPITAL, LLC RIA/Wealth	$5.1K 16.3K shares
ExodusPoint Capital Management, LP Hedge Fund•Multi-Strategy	$3.3K 10.5K shares

Options Activity

Institutions with the largest Call and Put options positions in APLT as of Q3 2025

Call Positions: 6
Call Value: $215.8K
Put Positions: 3
Put Value: $181.2K

Call Positions

Institution	Position Value
Hudson Bay Capital Management LP Hedge Fund•Multi-Strategy	$79.7K 1.3K contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$50.6K 836.0 contracts
J JANE STREET GROUP, LLC Institution	$30.7K 508.0 contracts
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$24.9K 415.0 contracts
W WOLVERINE TRADING, LLC Institution	$18.4K 301.0 contracts
DIADEMA PARTNERS LP Hedge Fund•Long/Short	$11.5K 190.0 contracts

Put Positions

Institution	Position Value
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$101.9K 1.7K contracts
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$72.8K 1.2K contracts
J JANE STREET GROUP, LLC Institution	$6.5K 108.0 contracts

Most Committed Institutions

Institutions with APLT as the highest % of their portfolio as of Q3 2025

Institution	Key People	Portfolio Weight	Ownership	Owned Since	Total AUM (Long)
Propel Bio Management, LLC Hedge Fund•Sector	Leen Kawas Managing Partner	6.83% $6.8M	7.84% 11.3M shares	Q4 2023 Held for 2 years	$99.9M
K Knoll Capital Management, LP Institution	-	2.52% $4.7M	5.42% 7.8M shares	Q2 2019 Held for 6y 6m	$186.6M
Vestal Point Capital, LP Hedge Fund•Long/Short	Ryan Christopher Wilder CIO	0.44% $8.6M	9.89% 14.3M shares	Q4 2023 Held for 2 years	$2.0B
S Simplify Asset Management Inc. Institution	-	0.17% $2.7M	3.12% 4.5M shares	Q1 2023 Held for 2y 9m	$1.6B
B Birchview Capital, LP Hedge Fund•Value	Matthew William Strobeck CIO	0.10% $136.1K	0.16% 225.0K shares	Q2 2025 Held for 6 months	$130.3M
Rock Springs Capital Management LP Hedge Fund•Sector	Nnamdi C Etoh CFO	0.07% $1.3M	1.44% 2.1M shares	Q4 2019 Held for 6 years	$1.7B
Scientech Research LLC Hedge Fund•Market Neutral	Le Duan Managing Partner	0.02% $63.6K	0.07% 105.1K shares	Q3 2025 Held for 3 months	$283.5M
T T. Rowe Price Investment Management, Inc. Insurance Manager	John Edward Robison President	0.01% $12.9M	14.86% 21.4M shares	Q3 2024 Held for 1y 3m	$161.58B
S SPHERA FUNDS MANAGEMENT LTD. Institution	-	0.01% $30.2K	0.03% 50.0K shares	Q1 2024 Held for 1y 9m	$416.3M
Hennion & Walsh Asset Management, Inc. RIA/Wealth	Kevin Douglas Mahn President	0.01% $171.1K	0.20% 282.8K shares	Q2 2024 Held for 1y 6m	$2.8B

Hedge Fund Spotlight

Discover hedge funds investing in APLT

Propel Bio Management, LLC

Hedge Fund • Sector

Portfolio ManagerLeen Kawas

Portfolio Value: $99.9M
Positions: 16
Last Reported: Q3 2025

Sector Allocation

Position in Applied Therapeutics

Market Value: $6.8M
Shares Held: 11.3M
Portfolio Weight: 6.83%
Owned Since: 2023-Q4

Top Holding	Sector	Market Value	Weight
1 Plains GP Holdings, L.P. PAGP	Oil & Gas Midstream Energy	$23.2M	23.23%
2 Achieve Life Sciences ACHV	Biotechnology Healthcare	$11.9M	11.94%
3 Akero Therapeutics AKRO	Biotechnology Healthcare	$10.9M	10.88%