BioCryst Pharmaceuticals

BCRX • NASDAQ

BioCryst Pharmaceuticals is a biotechnology company in the healthcare sector on NASDAQ, led by Charlie Gayer, with a market cap of $1.6B. As of Q3 2025, 92% of shares are held by 280 institutional investors, with VANGUARD GROUP INC as the largest holder at 10.38%.

President and Chief Executive OfficerCharlie Gayer

Market Cap$1.6B

Biotechnology

Healthcare

Employees531.0

Websitebiocryst.com

Country

United States of America

Overview

Overview of institutional ownership in BCRX as of Q3 2025 with a market cap of $1.6B

All Institutions

Institutions: 280
Value Held: $1.5B
Shares Held: 194.1M
Avg Position: $5.3M
Median Position: $467.9K

Hedge Funds

Hedge Funds: 57
Value Held: $437.2M
Shares Held: 57.6M
Avg Position: $7.7M
Median Position: $1.3M

Ownership Breakdown

Institutional (non-HF)

65.03%

$1.0B

Hedge Funds

27.44%

$437.2M

Retail & Other

7.53%

$120.0M

Based on market cap of $1.6B as of Q3 2025. Institutional (non-HF) excludes hedge funds to avoid double counting.

Biggest Investors

Institutions with the largest positions in BCRX as of Q3 2025

Institution	Key People	Position Value	Ownership	Owned Since	Total AUM (Long)
VANGUARD GROUP INC Institution	Salim Ramji CEO	$165.4M 0.00% of portfolio	10.38% 21.8M shares	≤ Q2 2013 Held for 12y 5m+	$6.69T
B BlackRock, Inc. Institution	-	$161.3M 0.00% of portfolio	10.12% 21.2M shares	Q2 2014 Held for 11y 5m	$5.67T
DEERFIELD MANAGEMENT CO /NY Hedge Fund•Long/Short	James Edward Flynn President	$92.4M 1.53% of portfolio	5.80% 12.2M shares	Q1 2023 Held for 2y 8m	$6.0B
STATE STREET CORP Institution	Ronald P. O'Hanley CEO	$74.4M 0.00% of portfolio	4.67% 9.8M shares	≤ Q2 2013 Held for 12y 5m+	$2.88T
K Kynam Capital Management, LP Hedge Fund•Long/Short	Jared Joseph Keller COO	$71.3M 5.31% of portfolio	4.47% 9.4M shares	Q2 2022 Held for 3y 5m	$1.3B
UBS Group AG Institution	Sergio P. Ermotti CEO	$45.3M 0.01% of portfolio	2.84% 6.0M shares	Q4 2014 Held for 10y 11m	$511.54B
A ALKEON CAPITAL MANAGEMENT LLC Hedge Fund•Long/Short	Jennifer Wendy Shufro Managing Partner	$41.5M 0.19% of portfolio	2.60% 5.5M shares	Q1 2022 Held for 3y 8m	$22.0B
ARROWSTREET CAPITAL LIMITED PARTNERSHIP Hedge Fund•Quant	Anthony Ryan CEO	$39.7M 0.02% of portfolio	2.49% 5.2M shares	Q3 2024 Held for 1y 2m	$158.92B
MORGAN STANLEY RIA/Wealth	Jed Finn CEO	$39.5M 0.00% of portfolio	2.48% 5.2M shares	≤ Q2 2013 Held for 12y 5m+	$1.65T
GEODE CAPITAL MANAGEMENT LLC ETF Provider	David Kenneth Lane CEO	$38.4M 0.00% of portfolio	2.41% 5.1M shares	≤ Q2 2013 Held for 12y 5m+	$1.57T

Net Capital Flow

Institutional buying and selling activity for BCRX in Q3 2025

Traded: −$27.3M
Buyers: 130
Sellers: 142
Total Bought: +$201.7M
Total Sold: −$229.0M
Avg Position: $4.6M

Biggest Buyers

Institution	Net Bought	Current Position
DEERFIELD MANAGEMENT CO /NY Hedge Fund•Long/Short	+$56.8M +7.5M shares	$92.4M 12.2M shares
Hood River Capital Management LLC Long Only Manager	+$18.0M +2.4M shares	$27.5M 3.6M shares
J JANE STREET GROUP, LLC Institution	+$11.9M +1.6M shares	$14.0M 1.8M shares
STATE STREET CORP Institution	+$9.9M +1.3M shares	$74.4M 9.8M shares
C Cubist Systematic Strategies, LLC Institution	+$9.5M +1.2M shares	$9.5M 1.2M shares
VANGUARD GROUP INC Institution	+$9.5M +1.2M shares	$165.4M 21.8M shares
ARROWSTREET CAPITAL LIMITED PARTNERSHIP Hedge Fund•Quant	+$7.2M +947.4K shares	$39.7M 5.2M shares
K Kynam Capital Management, LP Hedge Fund•Long/Short	+$7.0M +926.5K shares	$71.3M 9.4M shares
ORBIMED ADVISORS LLC Hedge Fund•Sector	+$6.8M +901.5K shares	$6.8M 901.5K shares
B BNP PARIBAS ARBITRAGE, SA Institution	+$4.8M +637.4K shares	$15.9M 2.1M shares

Biggest Sellers

Institution	Net Sold	Current Position
venBio Select Advisor LLC RIA/Wealth	−$24.7M −3.3M shares	$9.5M 1.3M shares
D D. E. Shaw & Co., Inc. Institution	−$20.3M −2.7M shares	$13.0M 1.7M shares
Walleye Trading Advisors, LLC Hedge Fund•Multi-Strategy	−$15.7M −2.1M shares	$1.7M 227.1K shares
VOLORIDGE INVESTMENT MANAGEMENT, LLC Hedge Fund•Multi-Strategy	−$11.5M −1.5M shares	$7.3M 957.0K shares
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	−$11.0M −1.4M shares	$3.5M 460.9K shares
M M&G Plc Institution	−$9.4M −1.0M shares	Sold Off 0 shares
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	−$9.1M −1.2M shares	$10.3M 1.4M shares
L LEGAL & GENERAL GROUP PLC Institution	−$7.4M −978.3K shares	$1.7M 226.2K shares
BANK OF AMERICA CORP /DE/ Institution	−$7.1M −938.3K shares	$14.4M 1.9M shares
DRIEHAUS CAPITAL MANAGEMENT LLC Hedge Fund•Event Driven	−$6.9M −766.9K shares	Sold Off 0 shares

Entry and Exit Activity

Institutions that initiated new positions or completely exited BCRX in Q3 2025

New Positions: 19
New Value: $12.5M
Exited Positions: 38
Exited Value: $54.5M

New Positions

Institution	Position Value
ORBIMED ADVISORS LLC Hedge Fund•Sector	$6.8M 901.5K shares
Bridgewater Associates, LP Hedge Fund•Global Macro	$3.1M 411.5K shares
Voleon Capital Management LP Hedge Fund•Quant	$816.2K 107.5K shares
C CI Private Wealth, LLC RIA/Wealth	$537.2K 70.8K shares
Csenge Advisory Group RIA/Wealth	$189.8K 25.0K shares
Empirical Financial Services, LLC RIA/Wealth	$185.5K 24.4K shares
FARALLON CAPITAL MANAGEMENT LLC Hedge Fund•Multi-Strategy	$182.2K 24.0K shares
M MQS Management LLC Hedge Fund•Global Macro	$98.5K 13.0K shares
A ATRIA INVESTMENTS LLC Institution	$92.8K 12.2K shares
S State of Alaska, Department of Revenue Institution	$90.3K 11.9K shares

Exited Positions

Institution	Previous Position
M M&G Plc Institution	$9.4M 1.0M shares
DRIEHAUS CAPITAL MANAGEMENT LLC Hedge Fund•Event Driven	$6.9M 766.9K shares
C Caligan Partners LP Hedge Fund•Activist	$5.7M 638.9K shares
Trexquant Investment LP Hedge Fund•Quant	$5.0M 559.2K shares
LORD, ABBETT & CO. LLC Long Only Manager	$4.8M 532.4K shares
H HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND Institution	$4.6M 512.2K shares
EAM Investors, LLC Long Only Manager	$3.0M 334.3K shares
Hudson Bay Capital Management LP Hedge Fund•Multi-Strategy	$2.7M 304.8K shares
Jain Global LLC Hedge Fund•Multi-Strategy	$2.2M 240.7K shares
Exome Asset Management LLC Hedge Fund•Sector	$1.5M 172.9K shares

Options Activity

Institutions with the largest Call and Put options positions in BCRX as of Q3 2025

Call Positions: 7
Call Value: $4.9M
Put Positions: 7
Put Value: $3.8M

Call Positions

Institution	Position Value
J JANE STREET GROUP, LLC Institution	$4.1M 5.3K contracts
Caption Management, LLC Hedge Fund•Long/Short	$365.8K 482.0 contracts
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$221.6K 292.0 contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$219.4K 289.0 contracts
W WOLVERINE TRADING, LLC Institution	- - contracts
Walleye Trading Advisors, LLC Hedge Fund•Multi-Strategy	- - contracts
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	- - contracts

Put Positions

Institution	Position Value
J JANE STREET GROUP, LLC Institution	$2.4M 3.1K contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$878.2K 1.2K contracts
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$521.4K 687.0 contracts
UBS Group AG Institution	$60.7K 80.0 contracts
Caption Management, LLC Hedge Fund•Long/Short	- - contracts
W WOLVERINE TRADING, LLC Institution	- - contracts
Walleye Trading Advisors, LLC Hedge Fund•Multi-Strategy	- - contracts

Most Committed Institutions

Institutions with BCRX as the highest % of their portfolio as of Q3 2025

Institution	Key People	Portfolio Weight	Ownership	Owned Since	Total AUM (Long)
K Kynam Capital Management, LP Hedge Fund•Long/Short	Jared Joseph Keller COO	5.31% $71.3M	4.47% 9.4M shares	Q2 2022 Held for 3y 5m	$1.3B
DEERFIELD MANAGEMENT CO /NY Hedge Fund•Long/Short	James Edward Flynn President	1.53% $92.4M	5.80% 12.2M shares	Q1 2023 Held for 2y 8m	$6.0B
Parkman Healthcare Partners LLC Hedge Fund•Long/Short	Gregory Arthur Martinez CIO	0.84% $7.7M	0.48% 1.0M shares	Q2 2024 Held for 1y 5m	$910.1M
Eversept Partners, LLC Hedge Fund•Long/Short	Rishi Rasesh Shah President	0.80% $10.4M	0.65% 1.4M shares	Q4 2022 Held for 2y 11m	$1.3B
R RICE HALL JAMES & ASSOCIATES, LLC Long Only Manager	Thomas W Mcdowell Chairman	0.78% $14.3M	0.90% 1.9M shares	Q2 2023 Held for 2y 5m	$1.8B
Q QTR Family Wealth, LLC RIA/Wealth	Chad Michael Hunter CEO	0.57% $1.2M	0.07% 157.1K shares	Q1 2025 Held for 8 months	$209.6M
DOLIVER CAPITAL ADVISORS, INC. RIA/Wealth	Edward Coe Tredennick President	0.54% $2.1M	0.13% 274.3K shares	Q3 2021 Held for 4y 2m	$386.5M
C Counterweight Ventures, LLC Institution	-	0.42% $708.8K	0.04% 93.4K shares	Q4 2023 Held for 1y 11m	$169.3M
D DAFNA Capital Management LLC Hedge Fund•Event Driven	Nathan Fischel CEO	0.42% $1.7M	0.10% 218.3K shares	Q4 2022 Held for 2y 11m	$397.7M
Semanteon Capital Management, LP Hedge Fund•Long/Short	Rajat Lal Managing Partner	0.41% $330.5K	0.02% 43.5K shares	Q3 2024 Held for 1y 2m	$79.7M

Hedge Fund Spotlight

Discover hedge funds investing in BCRX

ALGERT COLDIRON INVESTORS LLC

Hedge Fund • Quant

Portfolio ManagerRyan Zentner Lafond

Portfolio Value: $6.0B
Positions: 1,110
Last Reported: Q3 2025

Sector Allocation

Position in BioCryst Pharmaceuticals

Market Value: $5.4M
Shares Held: 713.1K
Portfolio Weight: 0.09%
Owned Since: 2021-Q3

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