UroGen Pharma

URGN • NASDAQ

UroGen Pharma is a biotechnology company in the healthcare sector on NASDAQ, led by Ron Bentsur, with a market cap of $1.0B. As of Q3 2025, 95% of shares are held by 159 institutional investors, with RTW INVESTMENTS, LLC as the largest holder at 9.82%.

Chief Executive OfficerRon Bentsur

Market Cap$1.0B

Biotechnology

Healthcare

Employees204.0

Websiteurogen.com

Country

United States of America

Overview

Overview of institutional ownership in URGN as of Q3 2025 with a market cap of $923.0M

All Institutions

Institutions: 159
Value Held: $877.2M
Shares Held: 43.9M
Avg Position: $5.5M
Median Position: $640.3K

Hedge Funds

Hedge Funds: 34
Value Held: $372.4M
Shares Held: 18.6M
Avg Position: $11.0M
Median Position: $3.9M

Ownership Breakdown

Institutional (non-HF)

54.69%

$504.8M

Hedge Funds

40.35%

$372.4M

Retail & Other

4.96%

$45.8M

Based on market cap of $923.0M as of Q3 2025. Institutional (non-HF) excludes hedge funds to avoid double counting.

Biggest Investors

Institutions with the largest positions in URGN as of Q3 2025

Institution	Key People	Position Value	Ownership	Owned Since	Total AUM (Long)
RTW INVESTMENTS, LLC Hedge Fund•Sector	Peter M Fong President	$90.7M 1.12% of portfolio	9.82% 4.5M shares	Q3 2021 Held for 4y 2m	$8.1B
Paradigm Biocapital Advisors LP Hedge Fund•Long/Short	Dr. Senai Nmn Asefaw CIO	$84.1M 2.49% of portfolio	9.11% 4.2M shares	Q3 2025 Held for 2 months	$3.4B
TORONTO DOMINION BANK Institution	Leo Salom CEO	$63.7M 0.12% of portfolio	6.90% 3.2M shares	Q3 2023 Held for 2y 2m	$51.2B
B BlackRock, Inc. Institution	-	$51.5M 0.00% of portfolio	5.58% 2.6M shares	Q2 2018 Held for 7y 5m	$5.67T
MORGAN STANLEY RIA/Wealth	Jed Finn CEO	$50.4M 0.00% of portfolio	5.47% 2.5M shares	Q3 2017 Held for 8y 2m	$1.65T
LEUCADIA NATIONAL CORP Institution	Richard B. Handler CEO	$43.9M 0.42% of portfolio	4.75% 2.2M shares	Q1 2024 Held for 1y 8m	$10.5B
SILVERARC CAPITAL MANAGEMENT, LLC Hedge Fund•Long/Short	Devesh Sharad Gandhi Founder	$31.5M 4.56% of portfolio	3.41% 1.6M shares	Q3 2023 Held for 2y 2m	$689.7M
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	Dan Michael Berkovitz Chairman	$29.3M 0.02% of portfolio	3.17% 1.5M shares	Q2 2020 Held for 5y 5m	$121.98B
A ACORN CAPITAL ADVISORS, LLC Venture Capital	Anthony Michael Gallo CCO	$25.1M 12.76% of portfolio	2.72% 1.3M shares	Q4 2024 Held for 11 months	$197.0M
S SG Americas Securities, LLC Institution	-	$23.1M 0.09% of portfolio	2.50% 1.2M shares	Q3 2024 Held for 1y 2m	$25.5B

Net Capital Flow

Institutional buying and selling activity for URGN in Q3 2025

Traded: +$113.8M
Buyers: 84
Sellers: 65
Total Bought: +$224.3M
Total Sold: −$110.5M
Avg Position: $4.8M

Biggest Buyers

Institution	Net Bought	Current Position
Paradigm Biocapital Advisors LP Hedge Fund•Long/Short	+$84.1M +4.2M shares	$84.1M 4.2M shares
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	+$17.5M +874.7K shares	$29.3M 1.5M shares
D D. E. Shaw & Co., Inc. Institution	+$17.2M +861.5K shares	$17.7M 888.9K shares
TCG Crossover Management, LLC Venture Capital	+$14.3M +717.3K shares	$14.3M 717.3K shares
VOLORIDGE INVESTMENT MANAGEMENT, LLC Hedge Fund•Multi-Strategy	+$13.7M +687.5K shares	$13.7M 687.5K shares
N Nuveen, LLC Institution	+$8.5M +424.4K shares	$10.1M 507.5K shares
RENAISSANCE TECHNOLOGIES LLC Hedge Fund•Quant	+$4.7M +236.9K shares	$5.5M 275.1K shares
B BNP PARIBAS ARBITRAGE, SA Institution	+$4.7M +236.4K shares	$6.2M 308.3K shares
Parkman Healthcare Partners LLC Hedge Fund•Long/Short	+$4.5M +225.9K shares	$8.0M 402.6K shares
ORBIMED ADVISORS LLC Hedge Fund•Sector	+$4.2M +210.6K shares	$13.7M 689.0K shares

Biggest Sellers

Institution	Net Sold	Current Position
Soleus Capital Management, L.P. Hedge Fund•Long/Short	−$30.0M −1.5M shares	$13.5M 679.0K shares
A ADAGE CAPITAL PARTNERS GP LLC Institution	−$11.4M −830.0K shares	Sold Off 0 shares
K Kynam Capital Management, LP Hedge Fund•Long/Short	−$9.2M −374.2K shares	$6.9M 282.4K shares
SILVERARC CAPITAL MANAGEMENT, LLC Hedge Fund•Long/Short	−$8.9M −445.2K shares	$31.5M 1.6M shares
R Rosalind Advisors, Inc. Institution	−$7.4M −542.4K shares	Sold Off 0 shares
Wildcat Capital Management, LLC Private Equity	−$6.8M −495.6K shares	Sold Off 0 shares
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	−$6.7M −337.6K shares	$2.9M 147.2K shares
BANK OF AMERICA CORP /DE/ Institution	−$3.1M −156.7K shares	$2.2M 108.5K shares
Walleye Trading Advisors, LLC Hedge Fund•Multi-Strategy	−$3.1M −155.7K shares	$3.8M 190.5K shares
C Cubist Systematic Strategies, LLC Institution	−$3.0M −218.8K shares	Sold Off 0 shares

Entry and Exit Activity

Institutions that initiated new positions or completely exited URGN in Q3 2025

New Positions: 16
New Value: $104.6M
Exited Positions: 22
Exited Value: $36.9M

New Positions

Institution	Position Value
Paradigm Biocapital Advisors LP Hedge Fund•Long/Short	$84.1M 4.2M shares
TCG Crossover Management, LLC Venture Capital	$14.3M 717.3K shares
MPM Oncology Impact Management LP Institution	$2.7M 135.0K shares
N NEOS Investment Management LLC Institution	$1.0M 50.5K shares
T TEMA ETFS LLC Institution	$1.0M 50.5K shares
Graham Capital Management, L.P. Hedge Fund•Multi-Strategy	$470.2K 23.6K shares
Q Quadrature Capital Ltd Institution	$353.7K 17.7K shares
C CLS Investments, LLC Institution	$219.6K 11.0K shares
FARALLON CAPITAL MANAGEMENT LLC Hedge Fund•Multi-Strategy	$219.5K 11.0K shares
Creative Planning RIA/Wealth	$208.4K 10.4K shares

Exited Positions

Institution	Previous Position
A ADAGE CAPITAL PARTNERS GP LLC Institution	$11.4M 830.0K shares
R Rosalind Advisors, Inc. Institution	$7.4M 542.4K shares
Wildcat Capital Management, LLC Private Equity	$6.8M 495.6K shares
C Cubist Systematic Strategies, LLC Institution	$3.0M 218.8K shares
S SIMPLEX TRADING, LLC Institution	$2.5M 185.0K shares
Point72 Asset Management, L.P. Hedge Fund•Multi-Strategy	$2.3M 168.8K shares
S Squarepoint Ops LLC Hedge Fund•Quant	$1.3M 94.3K shares
V Virtu Financial LLC Institution	$465.9K 34.0K shares
Scientech Research LLC Hedge Fund•Market Neutral	$358.5K 26.2K shares
A ALPS ADVISORS INC ETF Provider	$340.3K 24.8K shares

Options Activity

Institutions with the largest Call and Put options positions in URGN as of Q3 2025

Call Positions: 11
Call Value: $32.0M
Put Positions: 5
Put Value: $8.6M

Call Positions

Institution	Position Value
Caption Management, LLC Hedge Fund•Long/Short	$20.0M 10.0K contracts
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$7.4M 3.7K contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$1.7M 858.0 contracts
MILLENNIUM MANAGEMENT LLC Hedge Fund•Multi-Strategy	$897.8K 450.0 contracts
J JANE STREET GROUP, LLC Institution	$879.8K 441.0 contracts
A ADAR1 Capital Management, LLC Hedge Fund•Long/Short	$798.0K 400.0 contracts
W WOLVERINE TRADING, LLC Institution	$415.3K 217.0 contracts
Hudson Bay Capital Management LP Hedge Fund•Multi-Strategy	- - contracts
LEVIN CAPITAL STRATEGIES, L.P. Hedge Fund•Multi-Strategy	- - contracts
N Nantahala Capital Management, LLC Hedge Fund•Multi-Strategy	- - contracts

Put Positions

Institution	Position Value
SUSQUEHANNA INTERNATIONAL GROUP, LLP Private Equity	$3.4M 1.7K contracts
CITADEL ADVISORS LLC Hedge Fund•Multi-Strategy	$1.9M 963.0 contracts
J JANE STREET GROUP, LLC Institution	$1.9M 953.0 contracts
Caption Management, LLC Hedge Fund•Long/Short	$1.4M 700.0 contracts
W WOLVERINE TRADING, LLC Institution	- - contracts

Most Committed Institutions

Institutions with URGN as the highest % of their portfolio as of Q3 2025

Institution	Key People	Portfolio Weight	Ownership	Owned Since	Total AUM (Long)
A ACORN CAPITAL ADVISORS, LLC Venture Capital	Anthony Michael Gallo CCO	12.76% $25.1M	2.72% 1.3M shares	Q4 2024 Held for 11 months	$197.0M
SILVERARC CAPITAL MANAGEMENT, LLC Hedge Fund•Long/Short	Devesh Sharad Gandhi Founder	4.56% $31.5M	3.41% 1.6M shares	Q3 2023 Held for 2y 2m	$689.7M
Boxer Capital Management, LLC Hedge Fund•Long/Short	Aaron Isaac Davis CEO	3.78% $11.5M	1.24% 575.0K shares	Q2 2025 Held for 5 months	$303.5M
Paradigm Biocapital Advisors LP Hedge Fund•Long/Short	Dr. Senai Nmn Asefaw CIO	2.49% $84.1M	9.11% 4.2M shares	Q3 2025 Held for 2 months	$3.4B
S SUPERSTRING CAPITAL MANAGEMENT LP Hedge Fund•Long/Short	Guo Ting Managing Partner	1.73% $1.8M	0.19% 87.9K shares	Q4 2024 Held for 11 months	$101.5M
DIADEMA PARTNERS LP Hedge Fund•Long/Short	Timothy Beau Bassett CIO	1.25% $1.8M	0.19% 90.0K shares	Q4 2024 Held for 11 months	$143.3M
RTW INVESTMENTS, LLC Hedge Fund•Sector	Peter M Fong President	1.12% $90.7M	9.82% 4.5M shares	Q3 2021 Held for 4y 2m	$8.1B
Parkman Healthcare Partners LLC Hedge Fund•Long/Short	Gregory Arthur Martinez CIO	0.88% $8.0M	0.87% 402.6K shares	Q3 2023 Held for 2y 2m	$910.1M
T TANG CAPITAL MANAGEMENT LLC Institution	-	0.79% $20.0M	2.16% 1.0M shares	Q2 2025 Held for 5 months	$2.5B
Soleus Capital Management, L.P. Hedge Fund•Long/Short	Guy Bezalel Levy CIO	0.74% $13.5M	1.47% 679.0K shares	Q2 2025 Held for 5 months	$1.8B

Hedge Fund Spotlight

Discover hedge funds investing in URGN

Palo Alto Investors, LLC

Hedge Fund • Long/Short

Portfolio ManagerAngela Elizabeth Nguyen-Dinh

Portfolio Value: $540.4M
Positions: 44
Last Reported: Q3 2025

Sector Allocation

Position in UroGen Pharma

Market Value: $488.8K
Shares Held: 24.5K
Portfolio Weight: 0.09%
Owned Since: 2020-Q1

Top Holding	Sector	Market Value	Weight
1 Insmed INSM	Biotechnology Healthcare	$70.8M	13.11%
2 PTC Therapeutics PTCT	Biotechnology Healthcare	$52.9M	9.80%
3 Acadia Pharmaceuticals ACAD	Biotechnology Healthcare	$52.6M	9.74%