RA CAPITAL MANAGEMENT, LLC Portfolio Holdings
Q2 2025•63 long positions•$5.9B portfolio value
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Holding90 | Sector | Position↕ | Ownership↕ | Shares Δ↕ | Shares Δ % | Market Cap↕ | Owned Since↕ |
|---|---|---|---|---|---|---|---|
1 ASND Ascendis Pharma ASND | Unknown Unknown | $1.8B 29.9% | — 10.3M shares | — | — | — — | Q4 2022 Held for 2y 10m |
2  Vaxcyte, Inc. PCVX | Biotechnology Healthcare | $389.0M 6.55% | 9.28% 12.0M shares | 12.2M → 12.0M −$7.3M | -1.83% | $4.4B Mid Cap | Q2 2020 Held for 5y 4m |
3  Rhythm Pharmaceuticals, Inc. RYTM | Biotechnology Healthcare | $351.4M 5.92% | 8.74% 5.6M shares | 6.1M → 5.6M −$33.1M | -8.6% | $4.1B Mid Cap | Q2 2018 Held for 7y 4m |
4  Janux Therapeutics JANX | Biotechnology Healthcare | $258.5M 4.35% | 18.91% 11.2M shares | — | — | $1.4B Small Cap | Q2 2021 Held for 4y 4m |
5  Avidity Biosciences RNA | Biotechnology Healthcare | $206.4M 3.48% | 6.03% 7.3M shares | 6.3M → 7.3M +$27.4M | +15.33% | $3.6B Mid Cap | Q3 2021 Held for 4y 1m |
6  Arcellx, Inc. ACLX | Biotechnology Healthcare | $200.0M 3.37% | 5.51% 3.0M shares | — | — | $3.5B Mid Cap | Q2 2024 Held for 1y 4m |
7  89bio, Inc. ETNB | Biotechnology Healthcare | $195.3M 3.29% | 13.62% 19.9M shares | — | — | $1.4B Small Cap | Q4 2019 Held for 5y 10m |
8  ARS Pharmaceuticals, Inc. SPRY | Biotechnology Healthcare | $189.5M 3.19% | 11.06% 10.9M shares | — | — | $1.6B Small Cap | Q4 2022 Held for 2y 10m |
9  NewAmsterdam Pharma Company NAMS | Biotechnology Healthcare | $183.6M 3.09% | 9.03% 10.1M shares | — | — | $2.1B Mid Cap | Q4 2022 Held for 2y 10m |
10  Sionna Therapeutics, Inc. Common Stock SION | Unknown Unknown | $181.2M 3.05% | 23.69% 10.4M shares | — | — | $707.2M Small Cap | Q1 2025 Held for 7 months |
11  Cidara Therapeutics CDTX | Biotechnology Healthcare | $163.9M 2.76% | 16.08% 3.4M shares | 1.1M → 3.4M +$110.7M | +207.97% | $980.1M Small Cap | Q3 2024 Held for 1y 1m |
12  Edgewise Therapeutics, Inc. EWTX | Biotechnology Healthcare | $129.8M 2.19% | 9.41% 9.9M shares | 8.9M → 9.9M +$13.0M | +11.15% | $1.6B Small Cap | Q1 2024 Held for 1y 7m |
13  LENZ Therapeutics, Inc. LENZ | Biotechnology Healthcare | $122.5M 2.06% | 14.85% 4.2M shares | — | — | $838.2M Small Cap | Q1 2024 Held for 1y 7m |
14  Wave Life Sciences WVE | Biotechnology Healthcare | $118.3M 1.99% | 11.7% 18.2M shares | — | — | $1.1B Small Cap | Q4 2015 Held for 9y 10m |
15  Tyra Biosciences, Inc. TYRA | Biotechnology Healthcare | $116.7M 1.97% | 22.94% 12.2M shares | 10.6M → 12.2M +$14.9M | +14.68% | $518.0M Small Cap | Q3 2021 Held for 4y 1m |
16  GH Research GHRS | Biotechnology Healthcare | $93.6M 1.58% | 12.38% 7.7M shares | 6.9M → 7.7M +$8.9M | +10.54% | $777.8M Small Cap | Q2 2021 Held for 4y 4m |
17  Dyne Therapeutics, Inc. DYN | Biotechnology Healthcare | $92.5M 1.56% | 8.55% 9.7M shares | — | — | $1.2B Small Cap | Q1 2024 Held for 1y 7m |
18  Geron GERN | Biotechnology Healthcare | $85.1M 1.43% | 9.48% 60.4M shares | — | — | $987.2M Small Cap | Q2 2020 Held for 5y 4m |
19  Disc Medicine IRON | Biotechnology Healthcare | $83.5M 1.41% | 4.55% 1.6M shares | — | — | $1.9B Small Cap | Q1 2025 Held for 7 months |
20  Mineralys Therapeutics, Inc. MLYS | Biotechnology Healthcare | $83.2M 1.4% | 9.43% 6.1M shares | — | — | $921.6M Small Cap | Q1 2023 Held for 2y 7m |
21  Septerna, Inc. SEPN | Unknown Unknown | $73.9M 1.25% | 15.7% 7.0M shares | — | — | $477.2M Small Cap | Q4 2024 Held for 10 months |
22  Fulcrum Therapeutics, Inc. FULC | Biotechnology Healthcare | $70.4M 1.19% | 18.95% 10.2M shares | — | — | $388.1M Small Cap | Q3 2022 Held for 3y 1m |
23  Bicara Therapeutics BCAX | Unknown Unknown | $64.6M 1.09% | 12.75% 7.0M shares | — | — | $518.6M Small Cap | Q3 2024 Held for 1y 1m |
24  Vor Biopharma VOR | Biotechnology Healthcare | $64.2M 1.08% | 31.73% 39.6M shares | — | — | $39.7M Nano Cap | Q1 2021 Held for 4y 7m |
25  Taysha Gene Therapies, Inc. TSHA | Biotechnology Healthcare | $54.4M 0.917% | 9.01% 23.6M shares | 10.9M → 23.6M +$29.3M | +116.65% | $619.8M Small Cap | Q3 2023 Held for 2y 1m |
26  Dianthus Therapeutics DNTH | Biotechnology Healthcare | $53.4M 0.9% | 8.91% 2.9M shares | — | — | $583.4M Small Cap | Q1 2024 Held for 1y 7m |
27  RxSight, Inc. RXST | Medical - Devices Healthcare | $48.1M 0.811% | 9.11% 3.7M shares | 3.7M → 3.7M −$520.7K | -1.07% | $556.7M Small Cap | Q3 2021 Held for 4y 1m |
28  Tourmaline Bio TRML | Biotechnology Healthcare | $40.6M 0.684% | 9.88% 2.5M shares | — | — | $435.2M Small Cap | Q2 2024 Held for 1y 4m |
29  Scholar Rock SRRK | Biotechnology Healthcare | $40.3M 0.678% | 1.2% 1.1M shares | — | — | $3.2B Mid Cap | Q4 2024 Held for 10 months |
30  Climb Bio, Inc. CLYM | Unknown Unknown | $39.0M 0.656% | 46.49% 31.4M shares | — | — | $87.2M Micro Cap | Q3 2024 Held for 1y 1m |
31 GPCR Structure Therapeutics GPCR | Unknown Unknown | $31.5M 0.53% | — 1.5M shares | — | — | — — | Q4 2023 Held for 1y 10m |
32  Solid Biosciences Inc. SLDB | Biotechnology Healthcare | $28.3M 0.477% | 7.5% 5.8M shares | 4.3M → 5.8M +$7.2M | +34.2% | $376.3M Small Cap | Q1 2018 Held for 7y 7m |
33  Metsera, Inc. Common Stock MTSR | Unknown Unknown | $19.2M 0.324% | 0.643% 675.5K shares | — | — | $3.1B Mid Cap | Q1 2025 Held for 7 months |
34  Monopar Therapeutics MNPR | Biotechnology Healthcare | $18.3M 0.308% | 8.36% 511.2K shares | — | — | $203.6M Micro Cap | Q4 2024 Held for 10 months |
35  Nkarta, Inc. NKTX | Biotechnology Healthcare | $17.9M 0.302% | 15.23% 10.8M shares | — | — | $124.2M Micro Cap | Q3 2020 Held for 5y 1m |
36  Larimar Therapeutics LRMR | Biotechnology Healthcare | $17.5M 0.294% | 9.44% 6.0M shares | — | — | $191.4M Micro Cap | Q1 2024 Held for 1y 7m |
37  Acumen Pharmaceuticals, Inc. ABOS | Biotechnology Healthcare | $17.3M 0.292% | 24.65% 14.9M shares | — | — | $76.3M Micro Cap | Q3 2021 Held for 4y 1m |
38  Enliven Therapeutics ELVN | Biotechnology Healthcare | $17.0M 0.287% | 1.44% 849.0K shares | — | — | $1.2B Small Cap | Q4 2022 Held for 2y 10m |
39  Travere Therapeutics, Inc. TVTX | Biotechnology Healthcare | $17.0M 0.287% | 1.29% 1.2M shares | — | — | $1.4B Small Cap | Q4 2024 Held for 10 months |
40  4D Molecular Therapeutics FDMT | Biotechnology Healthcare | $16.9M 0.285% | 9.85% 4.6M shares | — | — | $185.3M Micro Cap | Q2 2023 Held for 2y 4m |
41  Hinge Health, Inc. HNGE | Unknown Unknown | $15.5M 0.262% | 0.385% 300.0K shares | 0 → 300.0K +$15.5M | New | $3.7B Mid Cap | Q2 2025 Held for 4 months |
42  Artiva Biotherapeutics, Inc. ARTV | Unknown Unknown | $14.9M 0.251% | 40.44% 9.9M shares | — | — | $39.2M Nano Cap | Q3 2024 Held for 1y 1m |
43  PepGen PEPG | Biotechnology Healthcare | $11.9M 0.2% | 32.67% 10.7M shares | — | — | $45.5M Nano Cap | Q2 2022 Held for 3y 4m |
44  Jade Biosciences, Inc. Common Stock JBIO | Unknown Unknown | $10.6M 0.179% | 3.3% 1.1M shares | 9.2M → 1.1M −$81.2M | -88.44% | $337.8M Small Cap | Q1 2025 Held for 7 months |
45  Tango Therapeutics TNGX | Biotechnology Healthcare | $10.2M 0.173% | 1.85% 2.0M shares | — | — | $581.0M Small Cap | Q2 2025 Held for 4 months |
46  Acrivon Therapeutics, Inc. ACRV | Biotechnology Healthcare | $9.9M 0.167% | 26.6% 8.3M shares | — | — | $38.9M Nano Cap | Q4 2022 Held for 2y 10m |
47  Eledon Pharmaceuticals, Inc. ELDN | Biotechnology Healthcare | $9.7M 0.163% | 5.96% 3.6M shares | — | — | $164.7M Micro Cap | Q4 2024 Held for 10 months |
48  Arcus Biosciences RCUS | Biotechnology Healthcare | $9.3M 0.156% | 1.07% 1.1M shares | — | — | $926.5M Small Cap | Q1 2025 Held for 7 months |
49 PCSC Perceptive Capital Solutions PCSC | Unknown Unknown | $8.0M 0.134% | 6.78% 750.0K shares | — | — | $117.5M Micro Cap | Q2 2024 Held for 1y 4m |
50  Omada Health, Inc. Common Stock OMDA | Unknown Unknown | $7.3M 0.123% | 0.703% 400.0K shares | 0 → 400.0K +$7.3M | New | $893.2M Small Cap | Q2 2025 Held for 4 months |